During pregnancy, various circulatory disorders may occur, which in any case are primarily dangerous for the fetus. In the second trimester, the expectant mother may develop a complication such as gestosis (or late toxicosis), which is associated with stagnation of blood in the capillaries. The beginning of this process is manifested in the appearance of edema, then changes occur in the kidneys, which are characterized by the appearance of protein in the urine, and, finally, this all concerns the brain (the woman is bothered by headaches, convulsions, and in severe cases, coma is possible).
Due to the fact that in our time all expectant mothers are under the constant supervision of an obstetrician-gynecologist, cases of severe gestosis are extremely rare (they are usually treated immediately at the stage of edema appearing).
Another “known” reason that can provoke circulatory disorders during pregnancy is FPI (fetoplacental insufficiency). Usually, its development is provoked by spasms of the blood vessels of the placenta, as a result of which the fetus “starves” due to the insufficient amount of oxygen and nutrients received. This process can be accompanied by the formation of blood clots in the blood vessels of the placenta. Even with minor feto-placental insufficiency, a child may develop mild perinatal damage to the nervous system, and developmental delays may also be observed. In severe forms of FPN, severe brain damage is possible.
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Therapeutic effect
Trental is a drug that improves microcirculation.
The active ingredient is pentoxifylline, it helps to normalize the rheological properties of the blood itself, prevents the process of platelet cell aggregation, and also significantly reduces its viscosity. Thanks to treatment with Trental, the normal shape of red blood cells is restored, which allows for better oxygen transport. Along with this, a vasodilator effect is recorded and vascular resistance decreases. According to research, Trental is effective in treating circulatory disorders in the brain. The drug is also successfully used for many diseases that are accompanied by deterioration of blood circulation in the vessels, including degenerative changes against the background of pathology of the vessels of the inner ear.
It is worth considering that during pregnancy, blood clotting increases, this is fraught with further deterioration of uteroplacental blood flow. In this case, the use of the medicine helps to thin the blood and improve its circulation in the placenta.
But you also need to pay attention to the fact that a slight increase in platelet levels (during the 3rd trimester) is considered quite normal. This is a manifestation of the body’s specific defense against possible bleeding during childbirth. The development of true fetoplacental insufficiency is observed quite rarely; such a diagnosis is made after Doppler ultrasound in cases of detection of delays in fetal development.
Compound
Trental tablets contain the active ingredient pentoxifylline 100 mg, as well as additional substances: silicon dioxide, starch, talc, lactose and magnesium stearate.
The shell consists of talc, titanium dioxide, sodium hydroxide, methacrylic acid copolymer, as well as macrogol 8000. The infusion solution concentrate in 1 ml contains the active substance pentoxifylline 20 mg, as well as additional substances: injection water and sodium chloride.
Extended tablets Trental 400 contain pentoxifylline in the amount of 400 mg, as well as additional substances: magnesium stearate, povidone, talc, hyaetellose. The shell contains: benzyl alcohol, talc, macrogol 6000, hypromellose, titanium dioxide.
Use of Trental during pregnancy
Taking into account the severity of the pathological process and the woman’s condition, outpatient or inpatient treatment can be prescribed. When carrying out therapeutic therapy at home, it is prescribed to take 1 tablet. twice or thrice a day. It is preferable to take the medicine simultaneously with food. The duration of treatment is usually 2-3 weeks, during which time the mother’s health improves significantly.
In case of serious circulatory disorders in the later stages, when there is pain in the lower abdomen, it is recommended to administer the drug to the pregnant woman intravenously (dropper or injections). Treatment is carried out in a hospital setting. Also, the doctor may additionally prescribe medications that are used only externally.
The drug dosage is usually 100-600 mg per day. Slow administration of the drug is indicated - no more than 100 mg in 1 hour. Some patients complain that it is scary to do IVs, so this procedure should be carried out under the supervision of medical staff.
In severe conditions, continuous administration of the drug throughout the day is indicated (a dropper is placed). The dosage is calculated taking into account body weight, but it is worth considering that it should not exceed 0.6 mg per 1 kg of weight.
Typically, the jet infusion procedure lasts approximately 5 minutes; it is recommended to carry it out twice a day, using 100 mg of medication. The duration of treatment is determined individually.
Interaction
According to the annotation, Trental enhances the effect of medications that affect blood clotting (thrombolytics, anticoagulants of direct and indirect effects), antibiotics (cefotetan, cefoperazone, cefamandole and other cephalosporins), valproic acid . Pentoxifylline enhances the effect of oral hypoglycemic agents, insulin, and antihypertensive drugs. Cimetidine can increase the level of the drug in the blood and increase the severity of side effects. With the simultaneous use of other xanthines, excessive nervous excitement of patients is observed.
Is Trental dangerous during pregnancy?
The instructions for the drug contain information that if blood flow A1 is impaired (the supply of nutrients to the placenta and uterus is slowed down during pregnancy), the medicine is not prescribed during the first trimester, since a teratogenic effect may occur, that is, intrauterine retardation of children's development may be observed.
Prescription in trimesters 2 and 3 is indicated, possibly, and is carried out with the aim of normalizing indicators that reflect blood flow in the placenta, thus, the baby’s body will receive vitamins and nutrients in full, the formation and growth of organs will correspond to the development calendar. The dosage of the drug is determined by the weeks of pregnancy. Starting from 34 weeks. the drug should be discontinued to reduce the likelihood of bleeding. After childbirth, the need to continue treatment is determined individually.
It is worth remembering that drugs are prescribed taking into account the possible benefits to the fetus. Due to the dilation of blood vessels in the uterus, there is an increase in the speed of blood flow and blood circulation in small capillaries. In addition, Trental prevents thrombus formation. The main advantage of the drug compared to other drugs with similar effects is its slight negative effect on the functioning of the cardiovascular system.
It is worth noting that the medicine is prescribed only by a doctor; Trental cannot be taken on its own.
Trental droppers: how safe are they?
Very often, Trental is prescribed during pregnancy in the form of tablets. However, in particularly serious cases, tablets are replaced with droppers. However, is it really safe?
Now the opinions of doctors are divided into two camps. Some believe that Trental will improve blood circulation and bring only benefits to the mother and child, others note the frequency of side effects and argue that there are studies proving that the main active ingredient of Trental has no medical value.
The instructions for use of Trental state that it is prohibited during pregnancy. Moreover, it is prohibited for children under 18 years of age. This fact causes so much controversy around this drug. Many mothers complain that side effects often occur after taking Trental. They are quite unpleasant, so many women refuse to use this remedy.
Side effects of the drug Trental:
- Nausea, which may develop into vomiting;
- severe headache or dizziness;
- Insomnia;
- Severe heaviness in the stomach;
- Decreased blood pressure, as well as tachycardia;
- Allergy.
Prescribing Trental is justified only when the risk to the fetus from the disease is many times greater than the harm from the medicine. A dropper with this drug has its own contraindications, which cannot but be experienced when taking it.
Contraindications for taking Trental:
- Trental should not be taken if you have a stomach ulcer;
- This drug is prohibited if you have low blood pressure;
- If you have poor blood clotting, you should not use Trental, as it thins it even more;
- Individual intolerance to the components of the drug.
Trental has a large number of side effects and very questionable effectiveness. That is why we advise you to have the phone numbers of several gynecologists at once, so that if your doctor prescribes you a drug that is questionable, you can be on the safe side by consulting with other specialists.
Contraindications and adverse reactions
Treatment with Trental should not be carried out if:
- Excessive sensitivity to components
- Opening of bleeding
- Signs of myocardial infarction
- Diagnosing hemorrhage in the brain or eyeball
- GW
- Disorders of the cardiovascular system, renal system and liver
- Reduced blood pressure
- Ulcerative pathologies of the gastrointestinal tract.
Medicines should not be taken by a patient under 18 years of age.
It is worth considering that Trental during pregnancy can provoke the development of side symptoms:
- Migraine-like headaches
- Development of convulsive syndrome
- Sleep disturbance
- Feeling of dry mucous membranes in the mouth
- Decreased blood pressure
- Diarrhea
- Attacks of nausea and vomiting
- The appearance of skin itching, rashes, swelling
- Bronchospasm, the occurrence of Quincke's edema.
Due to the fact that the drug is characterized by a large list of side effects, it is worth consulting with your doctor about the possibility of selecting a safer substitute.
Side effects
If the drug is used incorrectly, side effects of Trental may occur.
The solution may have the following side effects:
- Any stomach disorders (diarrhea, constipation);
- Acute pain and discomfort in the abdomen;
- Nausea, which may cause vomiting;
- Angina pectoris, accompanied by pressure in the chest and heart;
- Incessant itching all over the skin;
- Increased heart rate;
- Decreased blood pressure, headaches;
- Tissue swelling that occurs as a result of cardiac dysfunction (Quincke's edema);
- Frequent headaches and dizziness, possible fainting;
- Anaphylactic shock;
- Involuntary nervousness that develops into convulsions;
- Vision problems begin;
- Fever.
Side effects can also occur if the drug is used incorrectly. That is, if you do not follow the dosage or regimen of taking the solution.
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Analogs
Curantil is one of the analogues of Trental, as it has a similar effect on the body. The main advantage of this medicine is the minimal risk of developing side symptoms. In addition, Curantil tablets strengthen the immune defense.
The prescription of the medicine Curantil is intended for:
- Signs of fetal hypoxia
- Increased blood pressure
- Impaired blood circulation in the placenta
- Increased blood clotting rates
- Prevention of thrombosis and varicose veins.
In some cases, Curantil is prescribed for the purpose of prevention, but it cannot be used during the 1st trimester of pregnancy. When choosing a particular drug, you should evaluate its beneficial properties, list of contraindications and side effects.
Features of the drug use
Due to a possible teratogenic effect on fetal development, the drug is not prescribed in the first trimester .
In subsequent months, Trental can be prescribed until the indicators characteristic of full blood circulation in the placenta are achieved, or until the end of pregnancy.
After 34 weeks, the use of the drug is not recommended due to the increased risk of bleeding during childbirth.
Trental price, where to buy
The price of Trental in 100 mg tablets is 430 rubles for 60 pieces. Cost in Ukraine - 185 UAH.
The price of Trental 400 is 535 rubles for 20 pieces.
The price of Trental in ampoules of 5 ml is 170 rubles for 5 pieces. You can buy it in Ukraine for an average of 200 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Trental tablets p.p.o.
enteric solution 100 mg 60 pcs. Sanofi India Limited RUB 501 order - Trental tablets p.p.o. prolonged action 400 mg 60 pcs. Aventis Pharma/Sanofi India
RUB 1,491 order
- Trental tablets p.p.o. prolonged action 400 mg 20 pcs. Sanofi India Limited
RUR 616 order
Pharmacy Dialogue
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RUB 133 order
- Trental (tablet p/o 100 mg No. 60)Aventis Pharma
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134 RUR order
- Trental (tab.prolonged.p.pl/vol.400mg No. 60)Aventis Pharma
RUB 1,418 order
- Trental (tab.p/v.400mg No. 20)Aventis Pharma
RUR 687 order
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- Trental tablets 400 mg n20Sanofi India Limited IN
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- Trental tablets 100 mg n60 Sanofi India Limited, India
590 rub. order
- Trental tablets 400 mg 60 pcs Sanofi India Limited
1806 RUR order
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Pharmacy24
- Trental 5 ml N5 solution for injection Quinoin Pharmaceutical and Chemical Products Plant Private Co. Ltd., Ugorshchina
209 UAH order - Trental 400 mg No. 20 tablets Sanofi India Limited, India
215 UAH order
PaniPharmacy
- Trental tablets Trental tablets 400 mg No. 20 India, Sanofi India
219 UAH. order
- Trental ampoule Trental injection solution 100 mg ampoules 5 ml No. 5 Hungary, Chinoin
220 UAH order
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special instructions
Monitoring of blood clotting is required during simultaneous therapy with anticoagulants. Therapy with pentoxifylline is carried out under mandatory monitoring of blood pressure levels. In patients with diabetes, the medication may cause hypoglycemia . After surgical interventions, monitoring of hematocrit and hemoglobin levels is necessary. In case of unstable and low blood pressure, the dosage of the drug is reduced. There is no reliable data on the safety and effectiveness of Trental in children. Inhalation of tobacco smoke causes a decrease in the therapeutic effectiveness of the drug. During intravenous infusions, the patient should be in a supine position.
There is no description of the drug on Wikipedia.
Reviews about Trental
Reviews of Trental on forums
The drug works effectively, performing the tasks for which it is intended. However, side effects such as dizziness, nausea, insomnia are common. Often, when taking this medication, you experience a headache and high blood pressure.
Reviews from doctors
Very effective, really improves microcirculation, used for diabetes. You can use Trental intravenously and in tablets of 100 and 400 mg of the active substance. Side effects are common. The fluidity of the blood from the Trental solution and tablets increases, which can cause hemorrhage in the eyes, so it is better to consult an ophthalmologist before use.
