Acipol: instructions for use, dosage, course of therapy, analogues

Description of release forms for children and their composition

"Acipol" has been produced in Russia since 2006 in capsule form. Under the same brand, drops and suspensions are produced, which are not complete analogues. Dosage forms, dosages of active ingredients, and excipients in the preparations differ.

• “Acipol Baby” drops for children are produced in the form of an oil suspension. This is a two-component probiotic: the dropper bottle contains lyophilisate of lacto- and bifidobacteria (Lactobacillus rhamnosus + Bifidobacterium longum). Fillers: sunflower oil, alpha-tocopherol acetate, silicon dioxide. One serving of the drug is 5 drops (0.25 ml).
• Acipol capsules under a gelatin shell contain a cream-colored powder that smells like sour milk. These are acidophilic lactobacilli and polysaccharides of the kefir grain (genus Saccharomyces), specially grown and lyophilized (dried). The amount of probiotic in 1 capsule is 107 CFU, the weight of the prebiotic is 400 mg.

Acipol: composition and properties

Acipol is a medication that regulates the balance of intestinal microflora. The drug increases the number of beneficial bacteria, improves digestion, and improves immunity. The drug promotes better absorption of food and removal of toxic substances. As a result of regular intake, the child’s body is saturated with vitamins.

The drug consists of live lactobacilli acidophilus and kefir grains in dry form. They are grown on nutrient media and then dried. Once in a liquid environment, they come to life again and colonize the intestines, displacing pathogenic microorganisms. Additional probiotic components: gelatin, food additive E172, titanium dioxide.

The probiotic is produced in the form of capsules in an orange shell with powder inside. The contents of the capsules have a creamy tint and a sourish odor. Capsules are packaged in plastic jars or blisters. The enteric coating protects the bacteria from dissolving in the stomach, so they are only released when they enter the intestines.

Lactobacilli normalize the natural bacterial flora of the intestines, inhibit the proliferation of pathogens, and heal the digestive tract. And thanks to kefir fungus, the immune system is strengthened and digestion is normalized. In addition, milk mushroom has a beneficial effect on the nervous system and overall well-being of the child.

Acipol reduces the acidity of the intestinal environment, resulting in a decrease in the number of harmful bacteria. The drug normalizes the functioning of the digestive tract and improves intestinal motility.

Acipol for children is allowed to be taken from 3 months after birth. If the child is younger, you should consult a pediatrician before use.

Pharmacological action, pharmacodynamics and pharmacokinetics

Lacto- and bifidobacteria form the basis of the intestinal microbiota in healthy children. From the moment of birth, an individual qualitative and quantitative composition of microorganisms is formed, characteristic of each person. The microflora of the gastrointestinal tract is exposed to external and internal factors throughout life.

Probiotics preserve and restore the ratio of microorganisms in case of balance changes.

Live lactobacilli acidophilus create active colonies on the intestinal mucosa. Lactobacilli produce lactic acid and change pH. As a result, unfavorable conditions arise for bacteria (staphylococci, salmonella, etc.) that are sensitive to the acidity of the environment.

"Acipol Baby" contains lacto- and bifidobacteria. They reduce the activity and number of pathogenic and opportunistic microbes. Probiotics in infancy contribute to the formation of the immunological barrier and its restoration in children after various diseases.

Lactobacilli in the composition of Acipol Malysh drops synthesize substances that inhibit the growth of pathogen colonies. Lactic acid is needed for the development of the second component of the probiotic - bifidobacteria. The latter actively participate in the processes of digestion and absorption, in the synthesis of certain vitamins, and stimulate intestinal motility.

“Acipol Baby” does not contain lactose; in addition, lactobacilli are able to decompose this and other disaccharides. The drug is prescribed to children with lactase enzyme deficiency. The probiotic helps normalize microflora and prevent allergic conditions.

"Acipol" in capsules contains a probiotic and a prebiotic, and is a eubiotic. The differences between the components are significant. Probiotics are beneficial microorganisms typical of intestinal microflora. Prebiotics are a substrate that bacteria process to obtain food and energy and create stable colonies.

Taking a probiotic helps prevent digestive disorders, dysbiosis, malfunctions of the immune system, and allergies.

“Good” bacteria can die in the stomach due to strong stomach acid, or they may not “take root” in the intestines. Beneficial microorganisms, experiencing the negative impact of pathogens inhabiting the intestines, do not create sufficiently stable colonies and are excreted in the stool.

Acipol's analogs

Bifidumbacterin, Apibakt, Primadophilus, Laktogin, Laktovit forte, Bifikol, Bioflor, etc. (see more details Probiotics - list of drugs and dietary supplements).

Author:

Sabuk Tatyana Leonidovna hygienist, epidemiologist

Indications for use of the drug

In most cases, a probiotic is prescribed for dysbacteriosis (dysbiosis). The cause of imbalance in the intestinal microflora is most often infections, gastrointestinal pathologies, poor diet, consumption of contaminated food and water, and certain medications.

You can take Acipol for children with the following diseases and conditions:

• dysbiosis resulting from infection with salmonella and other pathogens of acute intestinal infections (AI);
• enterocolitis and colitis of infectious and non-infectious etiology;
• recurrent and chronic respiratory diseases;
• atopic dermatitis and other allergic conditions;
• increased susceptibility to pathogens;
• diarrhea of ​​various origins;
• after antibiotic therapy;
• intestinal colic.

Dysbacteriosis in newborns and infants is usually combined with weight loss. Such conditions may be consequences of antibiotic therapy. Infants are prescribed "Acipol" in drops. During pregnancy and lactation, a woman can take Acipol in the form of capsules or suspension.

Instructions for use and dosage for children

"Acipol", regardless of the dosage form, is prescribed orally half an hour before meals. Children take probiotics in liquid form. According to the instructions for use, the Acipol Baby dropper bottle should be shaken thoroughly before each use.

An infant is given 5 drops per day with a small amount of breast milk or formula in a bottle. The same amount of the drug is prescribed to children under 3 years of age. Mix with warm (not hot) milk. Do not add probiotic to food.

Duration of therapy or prophylaxis:

• chronic dysbacteriosis - from 10 to 15 days (repeated course after 1 month);
• dysbiosis after antibiotic therapy - from 10 to 15 days;
• diarrhea, OKI - from 5 to 8 days.

The probiotic in powder form under the shell better maintains viability.

It is recommended to swallow the capsules without chewing and wash them down with water. The shell protects the contents from destruction by stomach acid. The active substance is released in the intestines. You can open the shell, mix the powder with warm milk or boiled water, cooled to 37 ° C. The resulting suspension is then given to the child.

Dosage for children from 3 months to 3 years - contents of 1 capsule 2 or 3 times a day. A child over 3 years old is given 1 piece. 3 or 4 times a day. Open the capsule and mix the contents with water immediately before taking the product.

Acipol Active: instructions for use

Solvent water, sweetener fructose, inulin, lactobacilli Lactobacillus rhamnosus ATCC 53103, bifidobacterium Bifidobacterium longum CECT 7894, filler maltodextrin, acidity regulator citric acid (E 330), natural pear flavor, zinc citrate, preservative potassium sorbate (E 202), preservative sodium benzoate (E 211), anti-caking agent silicon dioxide (E 551), emulsifier magnesium stearate (E 470).

Content of active ingredients

* — TR CU 022/2011 “Food products regarding their labeling”, ** — “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)” of the EurAsEC Customs Union

Nutritional and energy value

Nutritional and energy value of 1 bottle (1 serving): fats less than 0.01 g, proteins less than 0.01 g, carbohydrates - 3.34 g, including sugars - less than 2.3 g; energy value – 13.38 kcal / 56.02 kJ.

What is Acipol® Active suspension:

1. This is a complex composition with EFFECTIVE
   components - living probiotic bacteria necessary for the functioning of the body, which enhance and complement each other’s action.
2. This is a MAXIMUM CONCENTRATION
   - 10 billion beneficial live bacteria in one bottle, which can provide maximum effectiveness for various disorders of the gastrointestinal tract in adults.
3. This is CONVENIENCE
   of reception. Only 1 time per day. You can take it with you (on vacation, to work, on the road).
4. This is TECHNOLOGICAL
   production - thanks to the unique “LONG LIFE CUP” technology of preserving the strength of living beneficial bacteria that are part of the complex (in the cap), the activity of the product is ensured throughout the entire shelf life.
5. This is high QUALITY
   in accordance with the GMP standard - a guarantee of the viability of bacteria until the end of the shelf life. Made in Spain.
6. The microflora of the human intestine is a very important factor that determines the functioning of the entire organism.
   Qualitative and quantitative changes in the state of intestinal microflora, or its IMBALANCE

   (changes in the ratio of microorganisms - representatives of normal microflora and pathogenic bacteria) are a common cause of disruption of the digestive process, the functioning of the immune system, and atopic reactions. The balance of normal intestinal microflora is an important factor in the body's immune defense.

   Disturbance of microbial balance in the intestine is otherwise called intestinal dysbiosis. There can be many reasons that disrupt the balance of intestinal microflora and lead to dysbiosis: stress, unbalanced poor nutrition, poor diet, diseases of the gastrointestinal tract, and insufficient consumption of prebiotics (dietary fiber and polysaccharides). Also, the development of dysbiosis syndrome is possible during travel, with changes in climatic conditions and diet.

   Acipol® Active suspension is an innovative product of complex composition and action, containing:

   • Probiotic Lactobacillus rhamnosus

   Probiotic Bifidobacterium longum

7. Prebiotic inulin
8. Mineral zinc.

The action of Acipol® Active is due to the properties of the active components included in the composition, which enhance and complement each other’s action (according to scientific data):

1. Lactobacillus (Lactobacillus rhamnosus)

   According to the results of clinical studies of the use of Lactobacillus, it was shown:

   • reducing the risk of developing microflora imbalance, including after taking drugs and agents that cause unfavorable changes in the qualitative or quantitative composition of the microbiocenosis of the gastrointestinal tract; against the background of stress and errors in diet;

   reduction in the frequency of colds;

2. increase in nonspecific resistance of the body.

What are the benefits of Lactobacillus (Lactobacillus rhamnosus)?

• produce metabolites that selectively suppress the growth of pathogenic microflora;
• have an immunomodulatory effect.

INTERESTING:

one study showed a significant reduction in body weight and fat mass when taking Lactobacillus rhamnosus and a prebiotic.

Lactobacilli promote the formation of lactic acid, and the acidic environment created in this way has a beneficial effect on the development of bifidobacteria, which are also present in the Acipol® Active suspension;

What are the benefits of Bifidobacterium longum?

The presence of a sufficient amount of bifidobacteria in the intestine and the normal state (BALANCE) of the intestinal microflora contributes to the synthesis of vitamins in the intestine, better absorption of food components and optimization of metabolic processes in the body.

A deficiency of bifidobacteria in the intestine can lead to gastrointestinal dysfunction.

Bifidobacteria support normal processes of parietal digestion in the intestine.

It is the complexes containing lactobacilli and bifidobacteria (including Lactobacillus rhamnosus and Bifidobacterium longum), according to a number of studies, that are characterized by good tolerability, a favorable safety profile, and the ability to reduce the risk of developing functional disorders of the gastrointestinal tract. An important property of the probiotics Lactobacillus rhamnosus and Bifidobacterium longum is their ability to attach to the intestinal epithelium, thereby ensuring and strengthening its barrier functions, as well as supporting immunity.

Application area

Acipol® Active suspension is recommended as a biologically active food supplement - an additional source of probiotic microorganisms (lactobacteria and bifidobacteria), zinc, and inulin.

The ingredients of Acipol® Active comprehensively help restore the balance of intestinal microflora, strengthen the immune system, and accelerate the body’s adaptation processes.

The complex can be used on the recommendation of a doctor in cases of imbalance in the intestinal microflora associated with the use of drugs that suppress one’s own normal microflora (including antibiotics), with a change in climate, usual diet, manifestations of atopic reactions, and during seasonal surges of colds.

Recommendations for use

Inside, during meals. Adults: 1 bottle 1 time per day with meals. Duration of treatment – ​​1 month.

Before use, it is necessary to combine/mix the filler in the bottle and the concentrate of active substances contained in the cap, according to the visual instructions:

1. press firmly on the dispenser cap;
2. wait until the contents of the dispenser cap enter the bottle;
3. shake the bottle thoroughly;
4. open the lid and drink the suspension;
5. If desired, the prepared suspension can be mixed with drinks at room temperature (water, fruit juice, yogurt, etc.). Do not mix with hot milk or other hot liquids!

Use the suspension immediately after preparation. The prepared suspension cannot be stored.

Contraindications

Individual intolerance to components. It is recommended to consult a doctor before use.

Storage conditions

Store in original, unopened packaging out of the reach of children at a temperature not exceeding 25 °C. Do not freeze.

Release form

A bottle with a liquid filler and a concentrate of the active substance for preparing a suspension. Bottles with a volume of 10 ml. 1, 5, 10 bottles per package.

Sales to the public through pharmacy chains and specialized stores, departments of retail chains.

Best before date

2 years from the date of manufacture.

Certificate of state registration

No. RU.77.9988.003.E.002607.06.17 dated 06/08/2017

Manufacturer

Erbozeta, SpA, Strada delle Seriole 41/43 ZI Gualdicciolo 47894, Chiesanuova, Republic of San Marino, for AB-Biotics, SA, Spain

Importer

Pharmstandard LLC, 123317, Russia, Moscow, st. Testovskaya, house 10..

Organization that receives complaints from consumers

PJSC "OTCIPHARM", 123317, Russia, Moscow, st. Testovskaya, house 10.. otcpharm.ru

Instructions, PDF version

Contraindications, side effects and overdose

"Acipol" in any dosage form is not prescribed for hypersensitivity to the main and/or any auxiliary components in the composition. The contents of the capsules should not be given to children under 3 months of age.

The probiotic does not cause side effects in recommended doses. However, individual negative reactions are possible: itching, skin rash, and from the gastrointestinal tract - constipation or diarrhea. There are no known cases of overdose.

Probiotic analogues

Suspension "Acipol Active" is a concentrate of the active substance in bottles with liquid filler (5 or 10 ml). This is a dietary supplement intended for adults. In addition to the probiotic, namely lyophilized lactobacilli and bifidobacteria, the drug contains the prebiotic inulin and the microelement zinc. The finished suspension has a pleasant pear taste. Shake the bottle vigorously before use.

Partial analogues in the composition of “Acipol Malysh” drops are the monopreparations “Lactobacterin” and “Bifidumbacterin”. These probiotics are produced in the form of powders for the preparation of suspensions for oral administration for intestinal diseases. They differ from more modern drugs in their low price (from 80 to 150 rubles).

It is better to give your child probiotics intended for children:

1. "Bifiform Baby", "Toddler" or "Kids".
2. "Rotabiotic Baby".
3. "Maxilak Baby".
4. "Hilak forte".
5. "Yogurt Baby"
6. "Yogulact".

The list includes products that contain several types of probiotic microorganisms. Often the composition is supplemented with a prebiotic. In this case, the drug is a syn- or eubiotic. Release forms: drops, powder in sachet, capsules. The cost of eubiotics, compared to monocomponent drugs, is higher (from 200 to 500 rubles).

It is difficult to determine which probiotic is best. It often happens that due to improper storage or other reasons, the content of microorganisms in the drug is lower than indicated in the instructions. In addition, some strains do not stay or do not last long in a particular person's intestines. One of the recommendations of experts concerns the duration of treatment. The course of use of pro- and eubiotics, after consultation with a doctor, can be increased to 1 month.

Effective analogues

Pharmacy chains offer a wide selection of probiotic preparations that can replace the probiotic if necessary. Analogues of Acipol:

• Acylact;
• Linux;
• Narine;
• Hilak Forte;
• Bificol;
• Enterol and others.

There are analogues that are lower in price than Acipol. But they are inferior in efficiency. In many preparations, beneficial bacteria are not stable in an acidic environment and are destroyed in the stomach, without reaching the small intestine. Therefore, they are more suitable for preventive purposes. The appropriateness of choosing one or another probiotic should be determined by the doctor, taking into account the age and condition of the patient.