Nemozol for children: instructions for use, indications and dosage

pharmachologic effect

Broad-spectrum anthelmintic drug. Most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia spp., Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.

Causing an irreversible disruption of glucose utilization, it depletes glycogen reserves in the tissues of helminths, prevents the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Prevention of helminthiases

Taking the drug or its substitutes for preventive purposes should only be done with the permission of doctors due to the high toxicity of the drug. Nemozol analogues differ in their effectiveness and cost. The most famous are “Piperazine” and “Gelmadol”. Another analogue of Nemozol is Dekaris (Levamisole).

Having learned information about how Nemozol works and how to take it, you must carefully follow the instructions of your doctor. Most often, after completing the course of treatment, the patient needs to undergo repeated tests 2-3 weeks later. And if the research results are negative, then taking albendazole was effective.

Preventive work against helminthiasis is quite relevant these days. Most experts believe that antiparasitic drugs should be systematically used for the purpose of prevention by both adults and children. Others insist that to prevent infection of the body with helminths and protozoa, it is enough to follow the rules of hygiene without resorting to synthetic medications.

Of course, hygiene must be observed in any case - every day for every family member. But there are situations when hygiene skills alone are not enough, and then Nemozol as a prophylactic agent comes in handy.

So, when is it advisable to take an anthelmintic drug for prophylactic purposes:

• a child or adult has become infected in the family;
• Pets live in the house permanently;
• human labor activity is associated with open ground, for example, among agricultural workers or utility workers;
• the child visits kindergarten or playgrounds for children, enthusiastically playing in the sandbox;
• a person regularly spends his free time fishing, hunting, hiking or on the beach;
• trip to an exotic location.

Prevention with Nemozol should be carried out for all family members, preferably twice a year - in spring and autumn. It is advisable to use chewable tablets for this purpose, since in addition to the active component, they contain vitamins necessary for the body.

You need to take medications according to the following schedule:

• first day - Decaris tablet;
• fourth day - Nemozol tablet.

In most cases, taking these drugs in combination is enough for them to have a preventive effect.

Pharmacokinetics

Suction and distribution

Practically not absorbed in the intestines. Cmax in blood plasma is usually observed 2-4 hours after administration. After taking the drug at a dose of 100 mg 2 times a day for 3 consecutive days, the plasma concentration of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 mcg/ml and 0.09 mcg/ml, respectively. Eating a high-fat meal results in a slight increase in the bioavailability of mebendazole.

The binding of mebendazole to plasma proteins is 90-95%. It is unevenly distributed in organs, accumulates in adipose tissue, liver, and helminth larvae. Vd is 1-2 l/kg.

In the liver it is metabolized to a 2-amino derivative, which does not have anthelmintic activity.

T 1/2 3-6 hours. More than 90% of the dose is excreted unchanged through the intestines. The absorbed part (5-10%) is excreted by the kidneys.

Pharmacokinetics in special groups of patients

In patients with impaired liver function, metabolic disorders, or difficulty in the outflow of bile, an increase in the concentration of mebendazole in the blood plasma may be observed.

Nemozol: general description

Nemozol is an anthelmintic medication that destroys both simple types of helminths and more complex parasites.

His scope of activity extends to neutralizing the processes performed by worms inside the human body. It acts on the shell of the worms, leads to its destructuring, and helps to stop the supply of food to unwanted guests.

Nemozol contains the main component that promotes the rapid neutralization of helminths - albendazole sulfoxide. Its effect extends to the muscles and cellular organelles of worms, which leads to inhibition and paralysis of the actions of various types of helminthic infestations.

The drug is produced in India and is considered one of the most effective medicines. Its impact extends both to adult sexually mature individuals and their eggs, and to larvae at the stage of initial entry and at the stage of migration.

To enhance the effect of the medication, Nemozol is taken while eating, along with high-calorie food, for example, a sandwich with butter. It is also recommended to introduce citrus fruits during treatment.

The period of action of the drug begins within a day after administration - the parasites begin to exit through the feces, both live and digested. Most of the medicine does not remain in the body for a long time; it is excreted in the urine.

Dosage

Inside with a small amount of water. The tablets can be chewed or swallowed whole. For young children, crush the tablet before use.

It is recommended to treat all family members simultaneously. During treatment, no special measures are required, such as following a special diet or taking laxatives.

Adults and children over 3 years old

For enterobiasis - 100 mg (1 tablet) once. Since re-infection with Enterobius vermicularis very often occurs, it is recommended to repeat treatment after 2-4 weeks.

Forms of release of the drug

Nemozol is available in the form of tablets (chewable and film-coated) and suspension.

White coated tablets are taken orally with meals and washed down with water. Their taste is not determined, since the pills are film-coated.

Chewable white tablets have a pleasant taste and smell. After chewing them, there is no need to drink a lot of liquid.

Both types of pills are packaged in blisters of 1 or 5 tablets each. This form of release is not suitable for children under three years of age.

The white suspension has a pleasant taste and smell. The medicine is taken during meals. Does not require drinking. The drug is packaged in 20 ml plastic bottles. The suspension can be taken by children from two years of age, since this form of release does not cause difficulty in swallowing.

Side effects

From the immune system: hypersensitivity reactions such as anaphylactic and anaphylactoid reactions.

From the hematopoietic system: neutropenia.

From the gastrointestinal tract: nausea, vomiting, abdominal pain, abdominal discomfort, diarrhea.

From the liver and biliary tract: increased activity of liver transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the skin and subcutaneous tissues: urticaria, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema.

From the nervous system: dizziness, headache, drowsiness, convulsions in infants.

From the urinary system: hypercreatininemia, glomerulonephritis (when used in high doses for a long time).

Laboratory and instrumental data: leukopenia, anemia, eosinophilia (when used in high doses for a long time).

Other: hair loss (when used in high doses for a long time).

If any of the side effects indicated in the instructions are aggravated or any other side effects not specified in the instructions are noted, the patient should inform the doctor.

Indications for use

The use of Nemozol in the fight against mixed helminthic infestations has shown effectiveness, which is why the drug is popular among specialists and patients. The active substance is effective for the following diseases:

• nematodes caused by the activity of roundworms, pinworms, duodenal worms, necator, etc.
• a disease that is caused by intestinal acne entering the body;
• giardiasis;
• echinococcosis occurring in the liver, peritoneum or lungs both at the cystic and alveolar stages;
• toxocariasis, etc.

Nemozol is taken both as a component of complex therapy to get rid of helminths, and after surgery as a result of advanced helminthic infestation.

Side effects

Before prescribing Nemozol, a specialist must study the patient’s medical history and identify possible consequences, since the drug is very toxic.

The following may be observed as side effects:

• redness and rash on the skin, severe itching;
• nausea, vomiting, bloating, constipation, etc.;
• severe headaches, dizziness, symptoms of meningitis;
• confusion, drowsiness during the day and insomnia at night, hallucinations, tremors of the limbs, convulsions;
• possible increase in body temperature to subfebrile levels;
• renal failure;
• yellowness of the skin, etc.

special instructions

In patients with diabetes mellitus, it is necessary to monitor the concentration of glucose in the blood.

With long-term use of the drug, it is necessary to monitor the peripheral blood picture, liver and kidney function.

Within 24 hours after administration, the consumption of ethanol and fatty foods is prohibited, and a laxative is not prescribed.

Periodic examination of smears of the anal area and feces after completion of treatment is mandatory: therapy is considered effective if there are no helminths or their eggs within the next 7 days.

This medicine contains lactose, therefore patients with rare hereditary lactose intolerance, lactase deficiency or impaired glucose/galactose absorption should not take this medicine.

The results of studies on the development of Stevens-Johnson syndrome and toxic epidermal necrolysis indicate a possible connection between their occurrence and the simultaneous use of mebendazole and metronidazole. There are no other data documenting cases of such drug interactions. Therefore, the simultaneous use of mebendazole and metronidazole should be avoided.

Use in pediatrics

There is no documented experience of using the drug in children under 3 years of age. However, there have been isolated reports of the occurrence of seizures in patients of this age group, therefore the use of this dosage form of the drug Vermox for the treatment of children under 3 years of age is contraindicated.

Overdose

If you follow the recommended doses of Nemozol, side effects may occur. A specialist will help you distinguish them from the symptoms of an overdose.

Clinic for exceeding the dose of anthelmintic drug:

• nausea;
• dizziness;
• vomit;
• drowsiness;
• blurred vision;
• loss of consciousness.

Obvious symptoms of overdose:

• speech disorder;
• visual hallucinations;
• jaundice;
• liver enlargement;
• coloring of secretions (sweat, saliva, urine, feces) orange and brown-red.

If such signs appear, you should stop taking Nemozol, rinse your stomach and drink activated charcoal. If there are signs of poisoning, symptomatic therapy is indicated.

The anthelmintic drug is available by prescription. Use for the treatment of children is indicated as prescribed by a doctor in the presence of parasitic infection. Patient reviews of Nemozol are positive, but unpleasant side effects are almost always observed, especially with large dosages.

To treat certain types of parasitic diseases, medications are used that have a detrimental effect on helminths. One of these drugs is Nemozol. Most often, worms affect children due to their failure to comply with hygiene rules. To treat a parasitic disease, tablets are often used, which are not suitable for the treatment of young children. This is due not only to the release form, but also to the complexity of the dosage. Nemozol is ideal for children, as it is available in tablet form and in suspension for oral use. Numerous reviews from doctors confirm the effectiveness of this remedy.

Pregnancy and lactation

The use of the drug during pregnancy is contraindicated.

There is no data on whether mebendazole is excreted in breast milk. If it is necessary to use the drug during lactation, it is recommended to stop breastfeeding.

This page provides a list of all Vermazole analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Vermazol: Nemozol
• The most popular analogue of Vermazol: Nemozol
• ATC classification: Mebendazole
• Active ingredients/composition: mebendazole

When calculating the cost of cheap Vermazole analogues, the minimum price was taken into account, which was found in price lists provided by pharmacies

This list of drug analogues is based on statistics of the most requested drugs

Active Ingredients

One tablet of Nemozol contains 400 mg of albendazole - the main active ingredient (in suspension - 100 mg in 5 ml). The drug has a wide range of effects, since it penetrates the intestinal tissues of parasites, thereby inhibiting the ability of helminths to reproduce and move. The consequence of treatment is the death of the worms and their removal from the body naturally. This method of action is only effective against larvae and adults without harming the eggs.

Chewable tablets contain small quantities of additional elements necessary for binding, storing and creating the taste of the medicine:

• corn starch;
• gelatin;
• citric acid;
• flavorings and others.

Film-coated tablets differ somewhat from chewable tablets in the composition of additional components. This is due to changes in shape, taste and other properties of the drug.

In addition to albendazole, the suspension includes: water, benzoic and sorbic acids, glycerin, flavoring to give the medicine a pleasant taste and smell, and other elements.

All analogues of Vermazol

Analogues in composition and indications for use

The above list of drug analogues, which indicate substitutes for Vermazole , is the most suitable, since they have the same composition of active ingredients and coincide in indications for use

Analogues by indication and method of use

Different composition, may have the same indication and method of use

Drug interactions

Taken simultaneously with Dexamethasone and Cimetidine leads to an increase in the amount of albendazole sulfoxide in the body.

Taking Nemozol simultaneously with Dexamethasone leads to an increase in the amount of albendazole sulfoxide in the body.

With the simultaneous use of Nemozol with cimetidine and dexamethasone, the concentration of albendazole sulfoxide in the blood increases.

How to find a cheap analogue of an expensive medicine?

To find an inexpensive analogue of a medicine, a generic or a synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so always consult a doctor before using any medication.

Contraindications

Absolute:

• Pregnancy period;
• Retinal damage;
• Hypersensitivity to the components of Nemozol and other benzimidazole derivatives.

Relative:

• Liver dysfunction (regular monitoring of liver function is required before and during treatment);
• Hematopoietic disorders;
• Breastfeeding period.

Nemozol's instructions indicate a list of contraindications that exclude the possibility of taking this drug. Let's list them:

• Pathological changes in the retina.
• Pregnancy and lactation.
• Cirrhosis and other structural pathologies of the liver.

• Albendazole intolerance.
• Deterioration of hematopoietic processes in the body.

If a patient experiences an acute disturbance of health during treatment, it is imperative to consult a specialist. If necessary, the doctor will change the treatment regimen or select a similar drug with a more gentle effect.

The drug is not used for:

• individual intolerance to albendazole or other benzimidazole derivatives;
• childhood (up to 6 years).

Nemozol should be taken with caution for liver cirrhosis.

Take Nemozol with caution when:

• dysfunction of the hematopoietic organs;
• liver failure;
• liver cirrhosis;
• cysticercosis, accompanied by damage to the retina.