Instructions for use of Pimafucin tablets - composition, indications, side effects, analogues and price

Pimafucin ointment has a local effect on the affected areas of the skin. The drug is a broad-spectrum antifungal agent.

Pimafucin is an antibiotic. The active ingredient, Natamycin, acts on fungus and other pathogens, thereby inhibiting the growth and reproduction of bacteria. The agent is able to penetrate inside the pathogenic cell, gradually destroying it.

Yeast infections of the genus Candida, as well as dermatophytes, are sensitive to the main component. The latter, in turn, are more resistant to the drug.

Composition and release forms

The instructions for use of Pimafucin indicate that the active component of the drug is natamycin, a substance that is of fungal origin. The medication is available in the form of cream, tablets, ointment, as well as vaginal suppositories, better known as rectal suppositories. The composition of each suppository includes one hundred milligrams of natamycin. Auxiliary components are:

1. cetyl alcohol;
2. hard fat;
3. sodium bicarbonate;
4. polysorbate.

The candles have a brown or yellow tint and are packaged in individual foil blisters. One cardboard pack can contain either three or six vaginal suppositories.

Main contraindications for use

When using rectal suppositories to treat thrush, it should be taken into account that they have some contraindications. Many drugs are prohibited for use in the following cases:

• the presence of individual intolerance to certain components of the drug;
• childhood;
• in the presence of severe diseases of the liver, kidneys, thyroid gland;
• pregnancy and lactation (some drugs are allowed);
• in the presence of serious intestinal pathologies.

Pharmacodynamics and pharmacokinetics

The instructions for Pimafucin suppositories state that the medication is able to fight yeast-like fungi, gradually destroying cell walls, and this leads to their death. The antibiotic exhibits its activity in the treatment of diseases caused by a wide range of pathogenic fungi. The maximum effect is achieved when treating thrush.

Dermatophytes are also very sensitive to the active substance of the drug. The antibiotic cannot have a systemic effect, since when using suppositories the components are not absorbed into the blood.

Tablets, ointment, suppositories “Pimafucin”: what does the medicine help with?

For diagnosed fungal infections of the nail tissues, or the skin, as well as mucous membranes, specialists recommend a course of therapy with the drug “Pimafucin”. The instructions reveal the main indications when the medicine helps:

• candidiasis of nails, dermis;
• dermatomycosis;
• various vulvitis;
• balanoposthitis;
• otitis caused by fungal flora;
• vulvovaginitis.

In the form of tablets, the product is very effective for fungal pathologies of the ear canal, in its outer part, as well as the mucous tissues of the oral cavity. The drug can be recommended for diagnosing candidiasis of intestinal loops, as well as after therapy with various cortecosteroids, medications from antibacterial subgroups, and cytostatics.

What do Pimafucin suppositories help with? Suppositories are recommended in the complex treatment of thrush, balanoposthitis and vulvovaginitis, as well as vulvitis and viginitis caused by fungal flora of the genus Candida.

Indications for use

Vaginal capsules are intended for the prevention and treatment of pathologies of the genital area in women. Diseases are almost always caused by fungi belonging to the genus Candida. Indications for use of the medication :

• thrush;
• vulvitis;
• vulvovaginitis.

Suppositories are effective in preventing relapses of vaginal candidiasis, as detailed in the instructions for use of Pimafucin suppositories. It eliminates fungal infections that affect the vagina and develop in cases of a sharp decrease in immunity or prolonged treatment with antibiotics.

Thrush often gets worse during pregnancy. This occurs due to changes in the patient’s hormonal levels and weakening of the body’s defenses. Intrauterine development is practically not affected by this disease, but the passage of a child through the birth canal can lead to the initiation of pathogenic microflora.

Doctors have found that the drug is harmless for expectant mothers. The active component of the drug is not able to penetrate the bloodstream and have a negative effect on the fetus. That is why Pimafucin is an antifungal agent , which is allowed both throughout pregnancy and during breastfeeding.

When to use candles

Pimafucin suppositories are used as the main medication for the treatment of gynecological diseases that arise due to the activity of a fungal infection.

The use of Pimafucin suppositories is prescribed for diseases such as:

• vulvovaginitis;
• vulvitis and vaginitis;
• mycosis.

Candles can be used not only for therapeutic purposes, but also for the prevention of fungal diseases. This measure is most often recommended when a decrease in the quality of the immune system is detected. Many patients are prescribed the use of Pimafucin in order to prevent the recurrence of thrush, against the background of long-term use of drugs from a number of antibiotics.

The active substance of Pimafucin is natamycin, a polyene antimycotic of the macrolide group, which has a wide spectrum of action.

Instructions for use

The female genital organs and the infectious and inflammatory diseases to which they are exposed are treated with Pimafucin. Experts recommend using one suppository per day. The drug provides a course of therapy. The frequency of one course lasts from three to six days. The attending doctor determines the duration of the appointment depending on the established diagnosis.

Antifungal therapy should continue for two days after the clinical signs of the disease (burning, itching, pathological white discharge) have been completely relieved. The suppositories must be inserted into the vagina as deeply as possible, while being in a horizontal position. Carry out the procedure once a day, preferably during evening preparations for bed.

If thrush becomes recurrent, the medication is additionally taken orally in the form of tablets (one tablet four times a day). The duration of treatment varies from ten to twenty calendar days. Internal administration can destroy fungal infections of the Candida group in the gastrointestinal tract. The chronic focus of the disease is subjected to sanitation.

Please note that sexual partners should be treated at the same time, since during unprotected sexual intercourse there is always a risk of becoming a carrier of a fungal infection. In order to treat candidiasis in males, it is necessary to use pimafucin ointment one to three times a day. The duration of therapy is determined individually, taking into account the possible risk of developing a disease such as candidal balanoposthitis.

The course of therapy cannot be interrupted. Within two to three days after the last symptoms of the fungal disease have disappeared, it is necessary to continue taking the medication. This precaution serves to prevent recurrence of the diagnosis.

How to take Pimafucin

The tablets are taken orally, regardless of food intake, since it does not affect the effectiveness of the antifungal components. Pimafucin dosage:

• for intestinal damage, adults take 100 mg of natamycin (1 tablet) four times a day, children - twice, the course of treatment is a week;
• in case of persistent vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (Pimafucin suppositories) to sanitize the source of infection inside the intestines, you need to take tablets 4 times a day, for a course of 10-20 days;
• when treating thrush and its variety on the genitals, the duration of treatment lasts up to three weeks (a break during menstruation is done only when using suppositories), together with a sexual partner;
• for nail candidiasis, tablets are taken along with cream four times a day for a course of 2-3 months;
• for widespread candidomycosis of the skin, 4 tablets per day are taken in a weekly course along with topical application of the cream;
• for onychomycosis, together with the use of natamycin and cream, 4 tablets are taken per day for a course of 2-3 months;
• The duration of treatment for a fungal infection is determined individually; after the symptoms disappear, treatment continues for several more days.

Contraindications and side effects

Pimafucin suppositories are well tolerated and safe, which cannot be said about other antimycotic drugs. There is only one significant contraindication to the use of the medication - the manifestation of allergic reactions and intolerance to the active ingredients, the main of which is pimaricin.

Pregnancy and breastfeeding also do not interfere with taking Pimafucin, but during the menstrual cycle it is necessary to pause. Blood released during menstruation can wash away the substance, and it will not be able to have the desired preventive effect. As an adverse reaction, you may experience:

1. swelling of the genitals;
2. severe itching;
3. burning and significant redness.

These signs have a temporary duration, and with timely use of the medicine they completely disappear. If suppositories are used in parallel with tablets, loose stools, nausea and vomiting may occur. Symptoms will go away immediately after the medication is stopped. Before using the medicine, the instructions for use of Pimafucin tablets should be carefully studied.

Side effects

To eliminate fungal infections of the intestines and skin, doctors prescribe the drug Natamycin - instructions for its use include information about indications, side effects, dosage form and composition.
The active substance of the drug acts on microorganisms, affecting the synthesis of vital substances in the membrane of the fungus.

Find out how to use medicines against fungal diseases, in what dosage.

The instructions for use of Natamycin contain information that, according to the pharmacological classification, this medicine belongs to antifungal drugs from the group of macrolides, or polyene antibiotics. The active substance of the composition is the component of the same name natamycin (also called pimaricin). This substance:

• penetrates the cells of the pathogen;
• disrupts protein synthesis;
• causes the death of the microorganism.

Vaginal suppositories	Ointment	Pills	Powder
Description	White suppositories in the shape of a torpedo	Homogeneous creamy substance of light yellow color	White round tablets	White homogeneous powder
Natamycin concentration, mg	100 per 1 piece.	20 per 1 g	100 per 1 piece.	Pure natamycin
Compound	Solid fat, adipic acid, sorbitan trioleate, cetyl alcohol, polysorbate, sodium bicarbonate	Decyloleate, water, cetostearyl alcohol, sodium lauryl sulfate	Potato starch, magnesium stearate, lactose, povidone, calcium carbonate, talc, sucrose	No additional substances
Package	3 pcs. in a strip, 1-2 strips in a pack	Tubes of 30 g	20 pcs. in a pack	500 g bottle

Natamycin belongs to antibiotics, antimicrobial and antiseptic agents used in gynecology and dermatology.

It is effective against pathogenic fungi, including yeast and Candida albican.

These pathogens affect the genital tract, but the drug has a fungicidal effect by binding sterols to fungal cell membranes. This breaks the integrity of the shell and kills microorganisms.

According to the instructions, the medication does not have a sensitizing effect and does not cause allergic reactions or resistance. The active substance of the composition acts quickly against fungal infections, relieves inflammation and itching. The tablets are enteric-coated, so they act only in the intestines and do not affect systemic blood flow.

The cream is used externally, suppositories are intended for intravaginal use, so the systemic concentration of natamycin in the blood is also not detectable.

Suppositories eliminate heavy vaginal discharge and are evenly distributed throughout all its parts after melting at body temperature.

A sufficient amount of the active component is not found in blood and biological fluids, so there is no data on pharmacokinetics.

According to the instructions, Natamycin suppositories are used by adult women, one at a time, for a course of 3-6 days. Suppositories are placed intravaginally, as deep as possible in the vagina. It is preferable to do this lying down once a day at night. Treatment begins a few days after the end of menstruation and is completed before its onset. Suppositories are contraindicated for use by children.

Powder

Instructions for use of the Natamycin powder substance state that it can be used externally, orally or intravaginally. The drug is applied to the skin up to several times a day, the course is determined by the doctor. The powder is applied intravaginally at night; the course of treatment with the drug should not exceed a week. For oral administration, 100 mg of the substance is indicated 2-4 times a day.

For oral candidiasis, make a suspension from the powder with clean water and take 1 ml 4-6 times a day. At the beginning of treatment, it is permissible to take a smaller dose - 0.5 ml every hour, for children - 0.5 ml 4-6 times a day. If necessary, the daily dose can be increased to 4 ml. The course of treatment depends on the extent of the affected area and is prescribed by the attending physician.

special instructions

When studying the instructions for use of Natamycin, it is useful to pay attention to the special instructions section. You can find useful information from it:

• Cannot use suppositories during menstruation;
• when treating thrush, the sexual partner should also be treated (it is optimal to use cream);
• during the period of using drugs during sexual intercourse, it is advisable to protect yourself with barrier methods of contraception;
• The medications do not affect the speed of psychomotor reactions and concentration, so you can drive cars and dangerous machinery while taking them.

During pregnancy and breastfeeding, the drug is not prohibited, but it should be used with caution and under medical supervision.

When breastfeeding (lactation), you should not apply the product in the form of an ointment to the mammary gland area. The use of tablets is indicated when the doctor assesses the risk to the fetus: it should be lower than the benefit to the mother.

Do not exceed the dosage specified in the instructions or change the prescribed treatment period.

During treatment with Natamycin, you should not drink alcohol, this leads to hypersensitivity reactions and possible liver dysfunction.

It is allowed to combine drugs from the line with each other or combine them with products based on griseovulfine or with antibiotic therapy in complex cases of treatment of dermatomycosis.

There are no other data on drug interactions between the drug.

Side effects

According to reviews, all Natamycin medications are well tolerated, but the risk of side effects cannot be ruled out. Frequently mentioned factors are:

• allergic reactions, itching, urticaria, skin rash;
• anaphylactic shock, Quincke's edema;
• burning sensation, hyperemia, irritation of mucous membranes and skin;
• vomiting, nausea, dyspepsia, abdominal pain, digestive tract discomfort;
• overdose manifests itself with similar symptoms, its cases are extremely rare, and when it occurs, symptomatic treatment is recommended.

The drugs are available without a prescription. It is recommended to store them in a cool, dry place at a temperature not exceeding 25 degrees for two years - for suppositories, four years - for cream, tablets and powder.

Analogues of Natamycin

On the shelves of pharmacies you can find many drugs similar to Natamycin. They are divided into those that have the same active substance, and those that have a different component composition, but exhibit the same effect. Analogues of Natamycin are as follows:

• Primafungin;
• Pimafucin;
• Natamax;
• Delvocid;
• Ecofucin;
• Vagitsin;
• Dalatsin;
• Clindamycin.

Natamycin price

Type of medicine	Internet price, in rubles	Pharmacy price tag, in rubles
Cream 30 g	260	280
Suppositories 6 pcs.	245	253
Tablets 20 pcs.	250	263

Reviews

Veronica, 28 years old

I developed thrush due to a cold. It was unpleasant to feel discomfort and burning. I decided to buy Natamycin vaginal suppositories because I read good reviews about them on the forum. I used one piece at night according to the instructions for a week, it helped eliminate annoying symptoms, itching, and unpleasant odor from the vagina.

Artem, 36 years old

My wife fell ill with thrush, and since we did not protect ourselves during sex, I also caught the fungus. My wife was treated with suppositories, I smeared my penis with Natamycin cream. We chose this drug for its affordable price and good effectiveness. He performed excellently, and within five days there was no trace of the problem. I hope we don't encounter her again.

Victoria, 41 years old

The child was diagnosed with a fungus in his ears, apparently picked up in the pool. I decided to make him turundas from cotton wool soaked in Natamycin cream. This advice, given to me by a friend, turned out to be effective. The ointment immediately relieved the pain and burning sensation, on the fourth day it eliminated congestion in the ear, and two weeks later the child was completely healthy. I will recommend the product!

Nikolay, 38 years old

The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and make recommendations for treatment based on the individual characteristics of a particular patient.

The following side effects may occur when using this medicine:

• oral administration – diarrhea, vomiting, nausea;
• External use – burning, irritation in the area of ​​application.

As a rule, adverse reactions from the gastrointestinal tract occur in the first days of treatment with Natamycin. Then the symptoms go away.

When used externally, a reaction is possible:

• itching;
• dry skin;
• burning;
• thinning of the skin;
• striae;
• perioral dermatitis;
• poor wound healing;
• depigmentation;
• hypertrichosis.

Important! If adverse reactions occur after taking the drug, you should consult a dermatologist. The doctor will cancel the prescription of Natamycin or give advice on its further use.

Overdose

There have been no cases of overdose with Natamycin. An ototoxic effect of the drug is possible in the presence of a perforated eardrum, if there is a direct effect on the middle ear.

Contraindications

Treatment with Natamycin is contraindicated in cases of:

• intolerance to individual components of the drug or hypersensitivity to natamycin;

• 
  tuberculosis;

• viral skin infections;
• open wounds;
• ulcers;
• ichthyosis;
• anogenital itching;
• skin reactions after vaccines.

In addition, the drug should be used with great caution when treating infants.

During pregnancy

During pregnancy, treatment with Natamycin is possible, but only under the supervision of a doctor if there are appropriate indications.

special instructions

In case of relapse and chronic form of fungal infection, therapy with suppositories should be supplemented by the use of tablets and external use of Pimafucin cream. Vaginal suppositories differ in the content of cetyl alcohol, so allergic reactions may occur in patients who are hypersensitive to this substance.

Throughout the entire prevention and therapy, drinking alcoholic beverages is strictly prohibited. This can lead to unpredictable consequences, even death. Alcohol provokes a fungal infection and minimizes antifungal therapy , as doctors and the instructions for Pimafucin tablets say.

Sexual contacts during treatment with the drug are allowed. But doctors emphasize that women need to get additional examination.

Clinical trial results

Clinical trials of Pimafucin have already been repeatedly conducted with the participation of women suffering from various types of fungal diseases that affect the genital area. At the end of the study, the effective action of the medication was confirmed in different situations. High effectiveness has been achieved in the treatment of infectious diseases caused by fungi of the genus Candida.

The Moscow Center for Obstetrics and Gynecology conducted its own study, which involved thirty-two women in the first three months of pregnancy. All patients had the first signs signaling candidal vaginitis. During therapy and prevention, they took one Pimafucin suppository before going to bed, and additionally took one tablet of the medication 4 times a day. After two days, almost all women’s unpleasant symptoms disappeared and their general health improved significantly.

Unsystematic use of Pimafucin leads to pathogenic microorganisms developing resistance to drugs, and the activity of the active ingredients is reduced. Doctors strongly recommend not to resort to self-medication and if you have any symptoms, contact the clinic for advice. Self-treatment almost always causes unwanted complications and complicates subsequent treatment of the disease.

As for reviews of Pimafucin suppositories for women, they are positive. Patients always talk about the high effectiveness, ease of use and safety of the antifungal substance.

An undoubted advantage is the use of suppositories during breastfeeding and pregnancy. The health of the fetus and the expectant mother is completely safe, since the medicine does not cause any harm. Due to this, Pimafucin has gained relevance and popularity among many women.

Analogs and price

Among the structural analogues of Pimafucin, Primafungin and Natamycin stand out, which contain identical active substances. The medications are harmless and can be taken during lactation and in the first trimesters of pregnancy. Throughout medical practice, side effects were recorded very rarely.

Cheap options include Livarol or Clotrimazole. The best analogue is Livarol suppositories, the active ingredient of which is ketoconazole. It can effectively control yeast-like fungi and dermatophytes.

The price of Pimafucin is five hundred rubles. Only Nystatin can be cheaper - eighty-five to ninety rubles.

Patient reviews

I suffered from vaginal candidiasis for three years.
On the advice of friends, I tried a bunch of different medications, but nothing helped. I decided to seek help from my doctor, who advised me to take Pimafucin suppositories. I've been using them for a year now and have no complaints yet. I recommend to everyone! Ekaterina
bought Pimafucin suppositories on the recommendation of a gynecologist.
At the time of her illness, she was breastfeeding her child and was very worried whether the drug would have a negative effect on her son’s health. The first time I took the medicine I was a little apprehensive, but fortunately there were no side effects. I recommend it to nursing mothers. Alina
With the help of Pimafucin, I managed to cure vaginal candidiasis.
The price of the medicine is not small, but it is worth it. For a package containing six suppositories, I paid 500 rubles. I heard different reviews about the medication and decided to try it myself. After a couple of weeks, candidiasis began to recede, and for nine months now it has not bothered me. I recommend! Love