During pregnancy, there is an exacerbation of many chronic diseases, including infectious ones. This is facilitated by a natural decrease in the body’s resistance, which is necessary for the successful bearing of a child. Treatment of such diseases is a very difficult task, because most drugs are prohibited, and folk remedies alone cannot destroy pathogenic microflora. Klion D is prescribed by doctors with caution during pregnancy. According to the instructions, its use is permissible from the 2nd trimester, in cases where the benefit to the mother is expected to be greater than the threat to the child.
General information about the drug
The predecessor of the presented drug is the drug “Klion”, in which the active ingredient is metronidazole. This precursor has long been used as the basis for the treatment of microbial and, in addition, protozoal infections. "Klion D" is considered a drug with expanded capabilities. Thanks to it, not only microbial and parasitic infectious diseases are treated, but also candidiasis, which is the scourge of women during pregnancy. This drug contains a substance called miconazole. This new component is able to increase the antifungal effect. There are a lot of reviews about Klion D suppositories during pregnancy.
Essentially, this is a vaginal tablet, but quite often it is called a suppository. Its composition makes it possible to carry out parallel treatment of candidiasis and trichomoniasis, which are often found in women. But due to the drug’s ability to negatively affect the organs of the fetus during its immediate formation, prescribing this drug to women in the first trimester is avoided.
Treatment with this medicine during the second and third trimester does not cause any dangerous consequences. For this reason, gynecologists prescribe it to eliminate identified Candida fungi, as well as Trichomonas, which without medical intervention can pose a great danger to the developing fetus. Therefore, its use during this period is considered justified, but it is important not to forget about some restrictions.
Reviews about Klion D during pregnancy are of interest to many.
How does Klion D 100 work? In what cases is it prescribed?
The drug Klion D is used to combat microbes and fungi on the vaginal mucosa.
Suppositories successfully treat thrush, dysbacteriosis, trichomoniasis and other types of inflammation, accompanied by heavy discharge, itching and rash. The drug is based on micronidazole, which has a therapeutic effect. In case of thrush, Klion D is prescribed exclusively in the third trimester of pregnancy or at the end of the second, when the fetus is already formed. The use of the drug in the first trimester is strictly prohibited; in these cases, treatment with more gentle drugs is acceptable.
Thanks to vaginal administration, Klion D suppositories are able to have a direct effect on the pathogen and restore the microflora. Before prescribing this drug, the attending physician must evaluate all the risks and benefits for the unborn child and his mother.
Children say! Five-year-old Dasha walks with her mother down the street and sees a large family getting into a seven-seater minivan with three rows of seats. The two younger children were seated in the very back row, and the older two were seated in the second row, behind their parents. Dasha, with fear and sympathy: “Mom, why did they put the kids in the trunk?”
https://youtu.be/3Nk7KEtprmA
Composition of the drug and its effect
It is a combination product containing two active ingredients in the form of metronidazole and miconazole. The first element destroys bacteria, as well as protozoan parasites, and the action of the second is aimed at combating fungus.
Finding a drug that would be effective against Trichomonas and not be toxic to humans is extremely difficult. Metronidazole is one of the most effective drugs today. For this reason, even despite the adverse reactions from its use, it is widely used for the treatment of trichomoniasis during pregnancy. Reviews of Klion D 100 mg confirm this.
Composition and pharmacological properties
"Klion D" is an antiprotozoal and antimicrobial drug that has a very wide spectrum of action. One vaginal tablet contains :
: active ingredient metronidazole - 250 mg, talc - 8 mg, corn starch - 150 mg, magnesium stearate - 2.5 mg, microcrystalline cellulose - 39.5 mg, colloidal silicon dioxide - 20 mg, glycerol - 7.5 mg, povidone - 22.5 mg.
Important!
This complex product acts very carefully in the body and does not in any way affect the beneficial microflora of the vagina.
Active ingredient metronidazole
very quickly destroys protozoa and anaerobic bacteria, and is also active against the following pathogenic microorganisms:
- Giardia intestinalis;
- Entamoeba histolytica;
- Trichomonas vaginalis;
- Gardnerella vaginalis.
In turn, miconazole
, another important component in the suppositories, stops the active progression of the Candida fungus, and also relieves associated unpleasant symptoms such as swelling, burning and rash.
How dangerous is the medication during pregnancy?
According to information obtained from experimental studies of metronidazole, which were carried out on pregnant mice and rats, no negative effects of this drug on the fetus were found even after administering a five-fold dose to females. After intraperitoneal administration of a human dose of this substance to rats, scientists recorded an increase in toxic effects on the fetus. However, when using the same dose of the substance in tablet form, no toxic effects on the fetus were detected.
According to reviews, Klion D is well tolerated during pregnancy in the 3rd trimester. It does not have any effects on the fetus.
For obvious ethical reasons, such trials have not been carried out on pregnant patients. But according to studies that were carried out on mathematical models based on the results of experiments on animals, no increase in the negative effect on the fetus was found when using metronidazole at any stage of pregnancy, including during the first trimester. Unfortunately, metronidazole cannot be used during pregnancy as widely as required. Klion D tablets can be used when all possible risks are reasonably assessed, and in addition, it is concluded that the benefits of this drug for the expectant mother will be higher than the hypothetical danger to her fetus.
Is the medication used in the 2nd trimester? According to reviews, “Klion D” is also used during pregnancy at this stage.
Analogues of Klion
There are many drugs of similar composition produced by different manufacturers (metronidazole, etc.). There are drugs that are similar in properties, but with a different active ingredient (ornidazole, dazolic, etc.). However, all of them are contraindicated in the first trimester of pregnancy and lactation. Their advantage is the lower frequency and duration of administration.
For any woman, pregnancy is not only a magical period, but also a very responsible one. Every day a new life grows in the womb of the expectant mother, which after a certain time will certainly appear to the world. Isn't this magic? And this little life is very fragile and vulnerable, and therefore mommy is simply obliged to take care of it in every possible way.
Unfortunately, not everyone's pregnancy proceeds calmly and smoothly. Due to any circumstances, the pregnant woman’s health condition may worsen. One of the most common problems of this kind today can be considered the vagina, aka. When this disease appears in a pregnant woman, the doctor often prescribes the drug Klion D as treatment. But while carrying a child, the use of any medications is extremely undesirable, so what to do?
Klion D refers to drugs with antimicrobial and antifungal effects, available in the form of vaginal tablets. Its main active ingredients are metronidazole and miconazole. Metronidazole is responsible for providing antiprotozoal and antibacterial effects, and miconazole, in turn, has an antifungal effect. Klion D is able to provide effective assistance in the fight against candidiasis and eliminate all its unpleasant symptoms.
In the instructions for the drug there is a warning that frightens many expectant mothers: Klion D is contraindicated during pregnancy, but its use may be justified in cases where the expected benefit to the mother outweighs the risk to the fetus. Klion D for the treatment of thrush in pregnant women is approved no earlier than the third trimester, although it is sometimes used in the second.
The fact is that in the first trimester the basic formation of all organs and systems of the baby occurs, and therefore it is then that he is most susceptible to the negative effects of any medications. The use of medications by a pregnant woman at an early stage of pregnancy can have a very bad effect, most often the fertilized egg simply stops developing. In the second trimester, the baby still remains vulnerable to many “chemical” dangers, which include drug treatment. Therefore, in order to avoid unpredictable consequences from the use of medications, including Klion D suppositories, it is better to abstain during pregnancy.
And yet, it also happens that the disease not only brings significant inconvenience to the mother, but can also cause undesirable consequences for the baby. The constant presence of infection in a pregnant woman’s body definitely does not benefit the fetus. Therefore, after comparing all the pros and cons, sometimes it still makes sense to resort to Klion D - only at a certain time and on the recommendation of a doctor.
According to doctors, in the second and third trimester, the use of Klion D with caution is possible. Both metronidazole and miconazole belong to groups A and B according to the classification of drugs during pregnancy. Such substances do not lead to disturbances in embryonic development, and therefore can be used during pregnancy as indicated. Klion D is prescribed only after the 12th week of pregnancy; treatment can last up to about three months, depending on the degree of the disease and the general condition of the pregnant woman.
If, nevertheless, the expectant mother doubts the safety of the prescribed treatment with Klion D, then she always has the right to refuse to use this medicine. In this case, the doctor should suggest alternative drugs of similar effect to treat the corresponding disease.
Especially for
— Tatyana Argamakova
From Guest
After 3 days, everything was swollen, colorless discharge began, like water, there were five times during the day... I saved myself with tea tree oil... already in the morning after the oil, everything disappeared as if by hand.
From Guest
Week 24, prescribed Klion D 100. The instructions immediately say that it is possible during pregnancy, but in the 2nd and 3rd trimester. Yesterday I tried it, a slight burning sensation all night (but it was prescribed in the instructions), introduce the norms, no big deal. We are waiting for improvement)
From Guest
During my first pregnancy, I had a bad smear (even in the first trimester), the doctor prescribed Klion-D, everything seemed to go away (although the form is really not convenient, it’s unpleasant to insert suppositories even moistened with water), a well-developed child was born. but, unfortunately, during the second pregnancy (4 years later) the situation is again the same: the first trimester and thrush ((((I’ll probably try another drug, I’ll consult a doctor.
From Guest
But only Klion helped me! I had thrush for a long time, high white blood cells, nothing helped. From Klion, yes, it itches a little, but 4 suppositories were enough for me and the smear became normal
From Guest
Terribly inconvenient to use. At least for me. It was very unpleasant and sometimes painful to use these tablets, because... These are not capsules, but tablets, ordinary, dry and pointed :(
Fully. Unfortunately, some negative conditions in the body, provoked by a changed background, cannot be prevented in advance, for example, changes in the vaginal microflora. The choice of medications prescribed by gynecologists is very small. Among them are the Klion D candles, which have become popular in recent years. although it has conflicting reviews, it greatly simplifies a woman’s life with. In this material we will consider not only publicly available instructions for their use, but also find out all the existing pitfalls.
Instructions for use of the drug
Reviews of “Klion D” during pregnancy will be discussed below.
These suppositories must be inserted into the vagina overnight, after holding them in water for a few seconds to facilitate the application procedure, as well as to prevent injury to the mucous membrane, which during pregnancy is more susceptible to all kinds of irritants. The medication should be taken in courses. Thus, the total duration of the course is about ten days. To check the effectiveness, vaginal smears are prescribed.
Possible side effects and analogues
The occurrence of side effects when using the drug Klion D is rare. As a rule, these are local reactions: redness, irritation, swelling, itching or tingling sensation, pain in the vagina. There is less burning and pain when urinating.
Systemic side effects during treatment with Klion D include headaches, nausea, and a decrease in the level of leukocytes in the blood. It is normal for urine to change color during use of the drug; it may turn red-brown. After completing the course of treatment, this feature disappears.
Klion D suppositories are prescribed by doctors with caution during pregnancy; reviews of their use are mostly positive. Among the negative aspects, some expectant mothers note the appearance of burning and itching in the vagina. If adverse reactions develop, you should consult a doctor to change the drug.
Analogues of Klion D are Metrogyl, Deflamon, Batsimex and a number of others. All of them contain metronidazole and are approved for use in the 2nd and 3rd trimesters.
Klion D is allowed to be used in the last two trimesters of pregnancy as prescribed by a doctor. This drug is indicated for infectious and inflammatory diseases of the genital organs caused by fungi or protozoan microorganisms. If you follow the method of administration and dosage, the risk of side effects is minimal.
Author: Olga Khanova, doctor, especially for Mama66.ru
Recommendations for use during pregnancy "Klion D" 100 mg
During the entire therapeutic course, it is recommended to abstain from sexual intercourse with a partner. In the event that complete abstinence from sexual intercourse during treatment is impossible, it is necessary to use a condom.
During treatment with this drug, it is prohibited to test for treponemes, since metronidazole can provoke false results of the Nelson test. During the use of Klion D, patients experience a decrease in the total number of leukocytes below the established norm. Therefore, in view of the threat of leukopenia, a general blood test is recommended during the entire course of therapy.
"Klion D" can, among other things, provoke side effects that can arise from the central nervous system. For this reason, during treatment with this drug, it is recommended to abandon any activity that requires increased concentration of attention, and, in addition, a high speed of psychomotor reaction, for example, driving a vehicle, conveyor belt, and so on.
This is confirmed by the instructions for use for “Klion D”. During pregnancy it is used with great caution.
Dosages, release forms and composition of Klion D
Currently, the drug Klion D is available in only one dosage form - vaginal tablets
. Klion D is not produced in the form of suppositories. The correct name of the drug is Klion D, however, the following options can be used in everyday life - “Klion D tablets” and “Klion D 100”. The drug is manufactured by the Hungarian pharmaceutical corporation GEDEON RICHTER, Plc. Klion D goes on sale in packs of 10 tablets.
Klion D tablets are white or almost white, have an oval, biconvex shape and a pointed end. On one side of the tablets there is an embossed “100” engraving. Tablet size 14 x 24 mm.
of metronidazole as active ingredients
and 100 mg
miconazole
. Metronidazole has antibacterial and antiprotozoal effects, and miconazole has antifungal effects.
As auxiliary components, Klion D tablets contain the following chemical compounds:
- sodium lauryl sulfate;
- Colloidal silicon dioxide;
- Magnesium stearate;
- Povidone;
- Sodium bicarbonate;
- Wine acid;
- Sodium carboxymethyl starch;
- Crospovidone;
- Hypromellose;
- Lactose monohydrate.
Side effects of the medicine
There is a large list of side effects regarding the medication, including the following:
- The presence of nausea, vomiting, distortion of taste, metallic taste in the mouth, decreased appetite, abdominal pain, constipation and diarrhea.
- Headache.
- Development of leukopenia or leukocytosis.
- The appearance of a burning sensation along with itching, pain and irritation of the vaginal mucosa.
- The occurrence of allergic reactions such as rash, hives, and itching of the skin.
- Discoloration of urine brown.
The most unpleasant side reactions are a feeling of severe itching and burning in the vaginal area, which can sometimes be unbearable. For this reason, women often stop taking this drug.
Absorption, distribution and excretion of Klion D
Klion D tablets are used for intravaginal administration, therefore they have a local effect, destroying pathogenic microorganisms directly in the woman’s vagina.
However, after inserting the tablet into the vagina, metronidazole contained in it as one of the active substances is able to be absorbed into the systemic bloodstream. In this case, the maximum concentration of metronidazole in the blood is achieved 6 to 12 hours after inserting the Klion D tablet into the vagina. Moreover, the concentration in the blood is 50% of that which is recorded when taking 100 mg of metronidazole orally. Due to its good absorption into the bloodstream, metronidazole from Klion D tablets used intravaginally penetrates into breast milk, through the placenta to the fetus, and into the structures of the spinal cord and brain. 60–80% of the metronidazole that enters the bloodstream is excreted by the kidneys in the form of chemical metabolites, which color the urine reddish or brown. The remaining 20–40% of metronidazole absorbed into the blood is excreted in feces through the intestines.
Miconazole, unlike metronidazole, is practically not absorbed into the systemic circulation. Therefore, miconazole when administered intravaginally is not detected either in the blood or in the urine. 8 hours after the administration of the Klion D tablet, 90% of miconazole is still present in the woman’s vagina, having a powerful destructive effect on Candida fungi.
Reviews about "Klion D" during pregnancy
It is one of the most discussed drugs among those prescribed to pregnant women for the treatment of various gynecological diseases. Such a vivid discussion is associated with its main side effect in the form of an unbearable burning sensation in the vaginal area. Women write that they experience similar sensations almost immediately after starting to use Klion D. It is noted that, in addition to unpleasant itching, pinkish discharge also appears.
Because of this side effect, many refuse to continue therapy without completing the full treatment course. But doctors do not recommend doing this, since after a few days, according to doctors and patients, the discomfort associated with itching disappears, and the treatment itself ultimately turns out to be very effective.
True, there is a small part of the reviews related to the fact that in certain situations “Klion D” turned out to be simply ineffective. In such comments, women say that the drug did not help them cure thrush, as well as trichomoniasis.
Methods of use, dosage
Of course, it is important to understand that you should never self-medicate, especially if you are pregnant. Therefore, only your attending physician can choose the most optimal method of use and dosage of this drug.
- Tablets for oral administration. The course usually lasts up to a week.
- Solution for infusion. This course of treatment can last a week; in some cases, the specialist comes to the conclusion that the duration of the course should be increased.
- Vaginal tablets. As a rule, this is the form of use of the drug that is usually prescribed to pregnant women. To administer the drug correctly, you will need to moisten it with water and remove the wrapper.
Indications
It is strictly not recommended to use Cliod D 100 for self-medication, especially during pregnancy. The drug is prescribed after tests for the treatment of the following diseases:
- vaginal candidiasis;
- vaginitis caused by fungal, bacterial and/or mixed microflora;
- for prophylactic purposes before various gynecological procedures.
When using vaginal tablets, the drug acts mainly locally and the active substances enter the general bloodstream in limited quantities. Therefore, only this form is allowed to be used by expectant mothers. However, the product cannot be used throughout pregnancy. In exceptional cases, it is permissible to use the drug from week 16.
Possibility of application taking into account the period
The beginning of pregnancy is the time when it is highly undesirable to use most medications. Klion D 100 is also included in the list of prohibited drugs. The first trimester is a contraindication to the use of the drug, since it contains two components that can negatively affect the baby, who at this time is not yet protected by the placenta.
Features of treatment with Klion D tablets
During the use of Klion D vaginal tablets, various local reactions may appear, such as discharge from the genitals, a feeling of discomfort, burning or itching.
Discharge after Klion D
Discharge after Klion D can be of various types. However, most often the discharge is semi-liquid or liquid, mucous, uncolored (transparent) or white, with a slight specific odor. In some cases, the discharge may be thick, with white flakes and a slight odor. In some women, with a severe inflammatory process after Klion D, orange, brownish or red discharge may appear, the color of which is due to the admixture of blood. Such discharge is not a reason to stop treatment, since it is associated with injury to the vessels located in the inflamed vaginal mucosa. If there is discharge mixed with blood, an urgent visit to a gynecologist is not required; you can go at the scheduled time. After completion of treatment with Klion D, discharge may be observed for 1 to 2 weeks.
Klion D – burning sensation during use
Klion D tablets can provoke locally irritating reactions, such as a burning sensation, itching or pain in the vagina. Therefore, burning sensation during the use of Klion D is a normal reaction of a woman’s body to the effect of the drug. A burning sensation may appear on any day of treatment, for example, on the first or fifth, etc. The presence of this subjective sensation is not an indication for discontinuation of the drug and cessation of treatment.
Klion D and alcohol
Klion D and alcohol are incompatible. This means that during treatment with Klion D you should refrain from drinking alcoholic beverages. Drinking alcohol during treatment with Klion D tablets can provoke undesirable reactions, such as cramping abdominal pain, nausea, vomiting, headache and hyperemia (redness) of the skin. The above reactions take place after the dose of alcohol taken is completely neutralized in the liver.
Klion D - therapeutic effects and scope of application
Klion D has antibacterial, antifungal and antiprotozoal effects, which are provided by two active components - metronidazole and miconazole.
Metronidazole provides a detrimental effect on protozoa (antiprotozoal action) and bacterial (antibacterial action) microorganisms. And miconazole provides an antifungal effect.
Metronidazole suppresses the processes of reduction of nitro groups inside the cells of protozoa and bacteria. As a result, the unreduced nitro group suppresses microbial DNA synthesis by combining with certain sections of nucleic acids. The absence of DNA synthesis entails the inability of microorganisms to reproduce and, accordingly, their death.
Miconazole inhibits the synthesis of one of the main lipid components of the fungal membrane - ergosterol. Due to the lack of ergosterol, the fungal cell membrane becomes loose and excessively permeable to water and salts, which enter the cell matrix in excess quantities from the surrounding space. Excess water and salts provoke a disruption of the normal balance within cells, which leads to the death of fungi. Miconazole has a selective effect, destroying only fungi, and without disturbing the composition of the normal microflora and acidity of the vagina.
Klion D is active against the following pathogenic microorganisms:
- Fungi of the genus Candida (mainly Candida albicans);
- Trichomonas vaginalis (Trichomonas vaginalis);
- Vaginal amoeba (Entamoeba histolytica);
- Gardnerella vaginalis;
- Guardia (Giardia lamblia);
- Bacteroides – Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus);
- Fusobacterium (Fusobacterium spp.);
- Veillonella spp.;
- Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens);
- Clostridia (Clostridium spp.);
- Eubacteria (Eubacterium spp.;
- Peptococcus (Peptococcus spp.);
- Peptostreptococcus spp.
Due to the peculiarities of the clinical spectrum of action of Klion D tablets, they are used mainly for the treatment of trichomoniasis, candidiasis and other infectious and inflammatory diseases of the vagina, provoked by opportunistic and pathogenic microflora (for example, gardnerellosis, clostridiasis, amebiasis).
Klion D - contraindications for use
Klion D is contraindicated for use if a woman has the following conditions or diseases:
- Leukopenia (decrease in the total number of white blood cells) currently or in the past;
- Organic diseases of the central nervous system, for example, epilepsy, strokes, etc.;
- I trimester of pregnancy (up to the 12th week inclusive);
- Breastfeeding period;
- Age under 12 years;
- Hypersensitivity or allergic reactions to any substances contained in the drug;
- Hypersensitivity or allergic reactions to other drugs with azole structure (for example, Clotrimazole, Imidazole, Ornidazole, etc.).
The above contraindications to the use of Klion D are absolute, that is, if they are present, the drug cannot be used in principle. In addition to absolute ones, there are relative contraindications, in the presence of which Klion D can be used, but with caution and under close medical supervision. Relative contraindications to the use of Klion D tablets include the following: 1.
Diabetes mellitus of any type;
2.
Microcirculation disorders.
Discharge and Klion D
In addition to all the side effects, special attention should be paid to such a circumstance as discharge during or immediately after taking the drug Klion D, which manifests itself completely differently in each woman and depends on individual circumstances.
On average, discharge can be reduced to a certain list, on the basis of which one can draw conclusions about the urgency of visiting a gynecologist:
- Most often, translucent or completely transparent discharge with barely noticeable or no odor is observed, which is the norm;
- Milky-colored discharge with small curd-like elements may also be observed, which is also normal and does not require special attention;
- Red, orange or pink substances are possible, because the drug has a mild irritating property and these formations are nothing more than small accumulations of blood. This is especially true for women who have problems with vaginal diseases.
Such discharge may be accompanied by unpleasant sensations in the lower abdomen and the time of their appearance is limited on average to 1, maximum 2 weeks after taking the drug. If the sensations are too pronounced and painful, it is better to replace it with a more loyal one or coordinate its use with a doctor.
A drug that has antimicrobial and antiprotozoal (targets protozoa) effects. Active substance - . Available in the form of tablets and injection solutions. Widely used in gynecology, urology, venereology, obstetrics and infectious diseases.
By integrating into the cell of a microorganism, metronidazole blocks the synthesis of DNA molecules (deoxyribonucleic acids), thereby preventing the pathogen from reproducing and causing its death. Klion-D is active against protozoa, obligate anaerobes (living without oxygen), and to a lesser extent against gram-positive bacteria. Does not affect aerobes (living in the presence of oxygen) and facultative anaerobes (can live in the presence of oxygen).
Information
Metronidazole crosses the placenta and is excreted in mother's milk, therefore the use of Klion-D is strictly limited in pregnant and lactating women.
