duphaston and frozen pregnancy signs 01/07/2018 13:23 01/07/2018 Igor Kostrov

Drugs duphaston or utrozhestan during pregnancy.

If a woman’s body lacks the natural hormone progesterone, in most cases one of the medications is prescribed to compensate for the lack of this important hormone. In most cases, doctors prescribe duphaston or utrozhestan during pregnancy.

Let's analyze these drugs separately.

Duphaston is a drug for internal use that has progestogenic activity in relation to the uterine mucosa. It is perfectly accepted by the body, without a negative effect on the liver, normalizes endometrioid tissue, does not disrupt the process of menstruation and ovulation, increases a woman’s chances of successful conception, reduces the threat of miscarriage, as well as missed pregnancy.

Duphaston differs from utrozhestan in that it does not have a tranquilizing effect on a woman’s nervous system, and it is not a tocolytic. In addition, it does not cause anabolic, corticosteroid and estrogenic effects on the female body. Duphaston contains dydrogesterone, and utrozhestan consists of progesterone. This is their difference. Progesterone is a hormone that is produced in the adrenal glands, placenta and corpus luteum. Both hormones have different chemical structures, which consist in the difference in one methyl group. Because of this, there are no big differences in the effects of duphaston and utrozhestan.

Utrozhestan is available in capsule form, so it has an advantage. They are taken orally, and in case of problems with the digestive system or toxicosis, they are taken intravaginally instead of suppositories.

The drug duphaston can increase the resistance of brain tissue to various damaging factors. It does not cause any adverse reactions and does not have an androgenic effect.

General recommendations for spouses planning a pregnancy after a frozen pregnancy

In addition to visiting the doctor and taking tests, the couple needs to change their course of life, creating favorable conditions for conceiving and bearing a baby:

1. Review your usual diet
   . You can strengthen your immune system and minimize the development of genetic pathologies in your baby by resorting to the theory of proper nutrition. A variety of vitamins and minerals perfectly restores the body, saturates it with strength and health. But preservatives, multi-colored dyes, taste improvers and other E-things contribute to various complications during pregnancy.
2. Optimize your daily lifestyle
   . Create your own special daily schedule, which will include walking in the fresh air, swimming or yoga, and good sleep. At first it will be difficult and unusual, but after a couple of days you will feel positive changes in your well-being.
3. Conquer bad habits
   . Avoid alcohol and nicotine, including passive smoking. Also try to limit sitting at the computer and the amount of coffee you drink and swallowed chips while surfing the Internet. It's better to take a few apples, a bottle of mineral water and go for a walk in the park.
4. Avoid stressful situations
   . At work and on public transport it is difficult to protect yourself from nervous and scandalous people, but still try not to reciprocate their attacks.

Every second frozen pregnancy could have been prevented. To save your baby, be sure to undergo preconception preparation before conception, lead an active lifestyle, review your diet, eliminate all the factors that led to the fading of pregnancy, and also create comfort and tranquility in your environment. Then your pregnancy will be successful and you will have a healthy and happy baby.

The use of duphaston and metipred during pregnancy.

Metypred is a drug for the production of methylprednisolone, which is a hormone of the adrenal cortex. It is an active glucocorticosteroid used in pregnancy planning, mainly as an inhibitor of male sex hormones or as an immunosuppressant. Metypred has immunosuppressive properties, which make it possible to use this drug both during pregnancy and when there is a threat of possible fetal rejection when the woman’s body turns on its defenses too actively, since methylprednisolone has the ability to artificially suppress the immune system. This helps to maintain pregnancy.

Also, an important quality of metypred during the intended conception is the reduction in the possible development of adhesive disease during various inflammations. Metypred also has an anti-inflammatory effect, in addition, it ensures the balance of the metabolism of all substances in the body. During pregnancy, the drugs duphaston and metipred create a suitable background for the normal development and course of pregnancy, mutually complementing each other. Thus, they increase the woman’s chances of successfully bearing a baby.

Is it safe to take medications?

In order to find out what effect Duphaston has on the gestation process, you need to familiarize yourself with its composition. It contains dydrogesterone, which is a synthesized hormone identical to progesterone.

Normally, it is involved in the process of preparing the endometrium of the uterus for fertilization, and after the formation of the embryo, dydrogesterone performs the functions of supporting the fetus.

Dydrogesterone is also called the “elixir of pregnancy”, as it is produced by the yellow corpuscle of the ovaries in the second part of the menstrual cycle. If fertilization does not take place, progesterone levels decrease.

During conception, on the contrary, it increases, as placental tissue begins to form it. If there are anomalies, the amount of substance produced in the corpus luteum is not enough, underdevelopment of the placenta occurs, oxygen starvation of the embryo, and as a result, developmental pathologies.

In addition, the hormone is needed for:

• accumulation of fatty deposits in the body of the expectant mother (reserves will be needed to feed the baby);
• relaxation of the smooth muscles of the intestines and uterus (the growth and preparation of the mammary glands for feeding is also regulated by progesterone);
• for the normal functioning of the body of a pregnant woman.

Some patients cannot get pregnant, while others suffer miscarriages. To improve the situation, gynecologists prescribe the drug before conception.

The hormone, synthesized in the laboratory, replaces the natural one and does its job.

Preparations Divigel and Duphaston during pregnancy.

Divigel and Duphaston prescribed during pregnancy are a popular combination of drugs, because for a successful conception the essential balance of the hormone progesterone and the hormone estrogen is extremely important. Duphaston is prescribed for progesterone deficiency, and the deficiency of estradiol is compensated by the prescription of Divigel. Divigel is a drug of the hormone estradiol. It comes in the form of a dosed gel, which is applied to the skin in a thin layer. In this case, the alcohol evaporates and the hormone is absorbed into the skin. This way it penetrates into the bloodstream and thus eliminates the possibility of the enzymes affecting the gastrointestinal tract if the drug passes through it, and in addition, the possibility of the initial stage of hepatic metabolism is eliminated. If Divigel and Duphaston are used together, regular blood tests should be performed to detect the content of estrogens and progestogens.

What tests should be taken after a missed abortion?

A consultation with a doctor is accompanied by a series of tests that will help you find out what caused this condition. It’s good if the cause was a random genetic mutation, but it’s better to make sure of this with the help of tests.

Tests that need to be taken:

1. General and biochemical blood tests, as well as a general urine test. These general clinical data will allow you to assess the general condition of the body and clarify the direction of the diagnostic search.
2. Gynecological smears for microflora and sexually transmitted infections. The degree of vaginal cleanliness and the presence of hidden genital infections, which can go unnoticed for a long time, are assessed.
3. A set of studies for: toxoplasma, cytomegalovirus, rubella, herpes, etc.
4. Clarification of blood type and to identify possible incompatibility in these parameters.
5. Determination of hormonal levels: check the level of sex hormones and the thyroid gland;
6. Spermogram, MAR test and other studies for men.
7. to identify problems with the uterus and appendages.
8. Genetic test: especially for older couples and those who have had a miscarriage not for the first time.

Tests will help you find out why the embryo died.

Should I use duphaston during pregnancy?

Whether to use the drug duphaston during pregnancy is decided only by a gynecologist. Mainly dydrogesterone, which is part of the drug, in proper doses contributes to the successful maintenance and progression of pregnancy, while normalizing the level of progesterone in the blood. If a woman has previously had cases of threatened miscarriage, miscarriage during in vitro fertilization, as well as artificial insemination, then she is prescribed duphaston. It is also prescribed to prevent miscarriage. If the drug is prescribed and used under the supervision of a physician, it is necessary to use it during pregnancy.

How to properly stop the drug

Taking Duphaston directly depends on how the pregnancy progresses. The need is usually present until 16-20 weeks. During this period, the placental layer is actively formed, which begins to independently produce and synthesize progesterone. In severe cases, the drug is taken up to 35-36 weeks.

How to cancel Duphaston? Under no circumstances should you suddenly stop taking the pills. This threatens miscarriage. The body must undergo adaptation. The regimen is prescribed by a gynecologist. As a rule, the dosage is halved within a week. In this case, a specialist monitors the process using ultrasound and blood test results.

If everything was done correctly, there are no consequences of drug withdrawal.

How does duphaston affect pregnancy?

Repeated scientific studies of this drug prove that duphaston has a beneficial effect on pregnancy. This drug, as it were, “prepares the ground” for successful conception, attachment and gestation of the fetus. The use of duphaston, due to various pathological processes, significantly reduced the number of spontaneous abortions in the first trimester of pregnancy, and also reduced the risk that any morphofunctional disorders of the maternal placenta and fetus may occur. When additional doses of the hormones progesterone or dydrogesterone enter a woman’s body, they can help the placental membrane create a hormonal, oxygen, and nutritional balance for the developing fetus in a timely manner. As a result, babies born while taking the drug, after birth, have normal indicators of physiological, mental development, and weight.

What is a frozen pregnancy and its causes

A frozen pregnancy is understood as the cessation of embryo development for up to 20-27 weeks (most often this occurs in the first months) and its subsequent death. There can be many reasons for this condition.

In most cases, this is some kind of genetic anomaly that prevents the fetus from further developing and causes its death. Such a case can occur even in completely healthy spouses.

Other causes of missed abortion include viral infections (rubella, influenza), alcohol abuse, severe emotional stress, gynecological diseases and others.

They learn about fetal fading either during a planned pregnancy or when a spontaneous miscarriage occurs. From a psychological point of view, a woman experiences a miscarriage more difficult, but from a health point of view, it is better for a non-viable fetus to leave the mother’s body than for it to begin to necrotize and endanger the woman’s health and life.

Frozen pregnancy is more common in the first trimester.

The use of duphaston for ongoing ectopic pregnancy.

In the case of an ectopic pregnancy, the fertilized egg begins to develop outside the woman's uterus. With the development of the fertilized egg, there is a threat of rupture of the organ in which the fertilized egg grows. In the case of an ectopic pregnancy, all medications without exception are stopped and the amount of surgical intervention required is determined. Duphaston is not a cause of ectopic pregnancy. The development of such pregnancy is determined by other reasons, for example, obstruction of the fallopian tubes, existing inflammatory processes, adhesions, or abnormal structures of the female genital organs.

What tests need to be taken after a frozen pregnancy?

Tests are an integral part of diagnosis. They help to find out the cause of the abnormality and determine subsequent treatment methods. But many women who find themselves in such a situation have a question: what tests should be taken if the fetus is fading? Let's figure it out together.

General tests

This name refers to several types of examination:

• general blood analysis;
• clinical urine analysis.

Procedures of this kind are mandatory for all patients who have undergone appropriate treatment. Firstly, their conduct helps to ensure that the woman is in good health upon discharge from the clinic (there is no anemia (or anemia) or inflammatory processes).

In addition, general tests help doctors suggest the cause of an abnormal pregnancy the day before. For example, such diagnostics allows us to identify problems with internal organs located outside the genitourinary system. Very often, the presence of extragenital pathologies causes the loss of a child.

Tests for infections

Often it is infections that provoke fetal death, so a woman must undergo this study, which includes:

• vaginal smear;
• blood test for infections.

Hormone tests

Hormonal imbalance is also a very relevant factor in the abnormality. Very often, doctors recommend that women take a hormone test. A specialist determines which biologically active substances (estrogens, progesterone, etc.) need to be examined. As directed by the doctor, the procedure is performed on certain days of the cycle. In addition, it must be done at least twice.

Additional Research

The above tests are not the final stage of the examination. The full program includes genetic research, instrumental diagnostics, studies for autoimmune diseases, etc. And here another important question arises for women: how to determine which tests need to be taken?

Duphaston during pregnancy with spotting.

During pregnancy, a woman may experience brownish discharge from the genitals. If this happens in the 1st or 2nd week of pregnancy, this is explained by the fact that the body is reconstructed into a new state when the hormonal background of the body changes. At the same time, we should not forget that such discharge can also be signs of an impending miscarriage or an acute drop in the level of hormones in the blood of a woman’s body. To maintain a woman’s pregnancy, she is prescribed duphaston or another progestogen drug.

Prescription of the drug duphaston during the pregnancy of a woman with fibroids.

The effect of duphaston on fibroids has not yet been studied enough. Nevertheless, experts are inclined to believe that progesterone taken in excess of the recommended therapeutic dose contributes to an increase in existing uterine fibroids. If progesterone drugs are used in small doses, then, on the contrary, they reduce its development and growth.

Duphaston for fibroids during pregnancy must be prescribed according to available data and indications strictly individually, having previously calculated the risk of possible complications and the likely benefits in order for the pregnancy to proceed well.

When can you start planning a pregnancy after a frozen pregnancy?

Pregnancy planning begins immediately after curettage and sending the embryo tissue for histological examination. This is the only study that shows the exact causes of embryonic death. Having received the microscopy results, the woman should contact her gynecologist and undergo a full examination.

Theoretically, you can get pregnant after the embryo has died in the next menstrual cycle. But doctors categorically advise against doing this. Firstly, it takes 1 to 3 months to restore female hormonal levels, and secondly, the unresolved cause of pregnancy failure will provoke the same tragic situation.

According to the World Health Organization, pregnancy planning is allowed after 6 months. This period of time is quite enough to find out the reasons for the fading pregnancy, undergo examination and eliminate all negative factors. Pregnancy in an earlier period can also end successfully, but the risk of fading will be high.

Obstetric practice shows that the female body, after three or more embryo failures in a row, retains this process in memory, and then, even if there are no compelling reasons, terminates the woman’s pregnancy. Therefore, it is so important to prepare for a new conception and make every effort to prevent the misfortune from happening again.

Important! A particularly important point at the stage of pregnancy planning after early miscarriage is the stabilization of the woman’s psychological state. If the fear of losing the baby again constantly worries a woman, the next pregnancy can also end tragically.

Safety of mother and unborn child

The drug should be prescribed according to strict indications, as it is considered a potent hormonal drug. However, it has been proven that correct use of Duphaston does not have a negative effect on either the mother or the fetus. It does not increase the level of female sex hormones in boys and does not cause weight gain in the mother. The drug does not interfere with liver function and helps improve lactation properties. During the use of the medicine, the development of birth defects in children associated with Duphaston was not registered. However, the tablets have side effects. Duphaston is taken until the date when its withdrawal does not cause fetal rejection. Throughout the entire period of taking the medicine, a woman may be bothered by:

• headache;
• rash;
• pain in the abdomen;
• minor bleeding from the uterus (you should immediately go to the gynecologist);
• skin itching;
• yellowing of the skin and slight malaise;
• allergic reactions in the form of urticaria.

The development of the listed side effects is very rare, so in many descriptions of the drug it is written that it does not have them. Basically, dysfunction of various organs occurs when a woman is predisposed to these pathologies.