Why is metypred prescribed when planning pregnancy?

Metypred when planning pregnancy general characteristics

If a woman has elevated androgens, then problems arise with the onset of conception, or when it occurs, miscarriages or frozen pregnancies occur.

By taking the drug Metypred, a woman regulates the concentration of male hormones, and therefore eliminates the symptoms of hyperandrogenism.

Metypred is a drug that contains methylprednisolone. Being an analogue of Prednisolone, Metypred is comparatively more effective

It has immunosuppressive, anti-inflammatory properties, and also suppresses free histamine, which is important for people with allergies

Metypred does not promote sodium retention in tissues, like its analog Prednisolone. This means that there will be no swelling.

When prescribed: indications

Of course, there is a large list of conditions for which glucocorticoids are recommended.
But in this article we will consider the use of Metipred only in obstetric practice. In the instructions for use you will not find indications: hormonal infertility. But then why do gynecologists prescribe this drug in some cases?

Globally, all indications can be divided into three groups - treatment of concomitant diseases in a pregnant woman, preparing the body for in vitro fertilization and in the case of respiratory distress syndrome in the fetus.

So, doctors prescribe Metypred:

• with insufficiency of the adrenal cortex;
• with hyperandrogenism (lots of testosterone);
• with sensitization to progesterone;
• to prevent fetal virilization in adrenogenital syndrome;
• for women with autoimmune diseases;
• for bronchial asthma;
• with antiphospholipid syndrome;
• in preparation for IVF;
• in the prevention of RDS in the fetus.

Testosterone is a male hormone, but women also need it. In particular, a sufficient amount of testosterone makes muscle tissue strong and a toned figure. In addition, testosterone provides sexual desire.

Release form

For the medical use of Metipret, the following release forms are used:

• for intravenous and intramuscular administration - hygroscopic lyophilisate or white powder (250 mg), which is prepared in solution;
• tablets (4 or 16 mg) for internal use.

16 mg tablets. on one side there should be an embossed inscription, engraving in the form of the code “ORN 346”. Otherwise, we can talk about falsification.

Impact principle

Since Metypred is a steroid hormone, it acts on the cell nucleus, prompting it to change the synthesis of certain proteins responsible for one or another function of tissues and organs.
This makes clear such a wide list of indications (we have indicated only a part) and various side effects.

An obstetrician-gynecologist prescribes this drug according to strict indications and if the benefit outweighs the risk.

The first signs that the active components of the medicine have begun to take effect are a regular menstrual cycle, reduced pain in the chest and uterus during PMS, a decrease in hirsutism and acne.

Side effects and contraindications

The main contraindications to the use of such a drug are children under 16 inclusive and lactation. Methylprednisolone is fully absorbed into milk, and therefore, if treatment is necessary, breastfeeding is stopped.

Prescribe with extreme caution to patients with the following diseases:

• heart attack suffered less than 6 months ago;
• renal or liver failure;
• gastrointestinal diseases;
• HIV, especially in the AIDS stage;
• diabetes mellitus type 1 and 2;
• nephrourolithiasis;
• acute psychosis;
• hypoalbuminemia.

Patients with these diseases are subject to more careful monitoring by the doctor prescribing the drug.

Side effects

Although the drug normalizes the balance of sex hormones in hyperandrogenism, it has a number of contraindications for use:

• Endocrine system: the occurrence of steroid diabetes, the development of pituitary obesity, disruption of the adrenal glands, a sharp increase in blood pressure, decreased glucose absorption
• Gastrointestinal tract: bleeding in the stomach or intestines, increased gas formation, loss of appetite, the occurrence of peptic ulcers, the development of pancreatitis
• CVS: changes in blood pressure, development of heart failure, increased susceptibility to thrombosis, arrhythmia and bradycardia
• NS: paranoid state, the appearance of hallucinations, the development of depressive syndrome, insomnia, euphoria
• Organs of vision: damage to the optic nerve, as well as trophic pathologies of the corneal surface
• Musculoskeletal system: atrophic changes in muscle tissue, development of steroid myopathy, tendon injury, occurrence of osteoporosis

Among the side effects of IVF are the occurrence of allergic reactions.

If you follow all the doctor’s recommendations, as well as treatment regimens, the use of Metipred will promote conception and the normal course of pregnancy without the development of side symptoms.

Contraindications

In this case, the instructions will come in handy, which necessarily indicate all the contraindications - those conditions and diseases for which this drug cannot be taken at the stage of pregnancy planning:

• severe arterial hypertension;
• heart failure;
• nephritis;
• acute endocarditis;
• severe osteoporosis;
• diabetes;
• peptic ulcer of the duodenum and stomach;
• mental illness;
• polio;
• glaucoma;
• infections - mainly viral and amoebic;
• syphilis;
• systemic mycoses;
• Itsenko-Cushing syndrome;
• hypersensitivity to the active substance - methylprednisolone.

If during examination at the stage of pregnancy planning these diseases are revealed, Metypred is not prescribed: some alternative is looked for with a minimum of contraindications and side effects. If there are no such pathologies, the drug is successfully used to correct the situation. However, sometimes it has too active an effect on some body systems (this depends on individual indicators), so there are cases when it is canceled after its appointment.

Contraindications and side effects

The list of contraindications specified in the annotation includes the following:

• diseases of the hypothalamic-pituitary system (Cushing's syndrome);
• fungal diseases of the mucous membranes, skin and internal organs;
• syphilis;
• nephritis;
• tuberculosis;
• chicken pox;
• shingles;
• liver or kidney failure;
• ulcer of the duodenum, stomach;
• glaucoma;
• polio;
• osteoporosis (moderate and severe);
• inflammation of the inner lining of the heart;
• myocardial dysfunction;
• persistent increase in blood pressure;
• gastritis;
• obesity of the third and fourth degree;
• hypothyroidism;
• thyrotoxicosis;
• diabetes;
• mental and psychosomatic disorders;
• hypersensitivity to the main component of the drug.

The risk of side effects is directly related to the length of time you take the drug and the prescribed dosage, and the list of them is very extensive:

• allergic reactions (skin itching, rash, anaphylactic shock);
• leukocyturia, withdrawal syndrome;
• withdrawal syndrome;
• a sharp decrease (or increase) in body weight, toxic (steroid) myopathy, osteoporosis, muscle tendon ruptures;
• the occurrence of steroid acne, stretch marks, increased pigmentation of the skin and thinning, petechiae, ecchymosis;
• weakness, fatigue, arrhythmia, hypokalemia, muscle myalgia, hypernatremia, increased sweating;
• exophthalmos, darkening of the back of the lens of the eyeball, surges in intraocular pressure causing damage to the optic nerve;
• attacks of headaches, vertigo, dizziness and fainting, convulsions, sleep disturbances, nervousness, paranoia, increased intracranial pressure, depression, hallucinations, manic-depressive psychosis, mood swings, delirium, attacks of aggression.
• flatulence, hiccups, loss of appetite, perforation of the stomach wall, gastrointestinal bleeding, erosive esophagitis, nausea and vomiting, steroid ulcer of the stomach and duodenum, hypercoagulation, pancreatitis;
• slow wound healing, thrombosis.

REFERENCE! Drugs with similar effects: Medrol, Urbazon, Solu Medrol, Prednol-L.

Drug interactions

• With salicylates - the effect of salicylates may be reduced.
• With rifampicin - increased clearance of methylprednisolone. P
• When taken simultaneously with NSAIDs, the risk of erosive and ulcerative lesions of the gastrointestinal tract may increase. When used simultaneously with insulins, metformin and glibenclamide, the effectiveness of hypoglycemic agents decreases.
• When used in combination, the effect of phenytoin may be reduced.
• With pancuronium - reduction of neuromuscular blockade.
• With pyridostigmine and neostigmine, the development of myasthenic crisis is possible.
• With itraconazole and ketoconazole, the concentration of methylprednisolone in the blood plasma increases.
• With methotrexate - synergistic immunosuppressive effects.
• When used simultaneously with phenobarbital and phenytoin, the clearance of methylprednisolone increases and its effectiveness decreases.
• When used together with barbiturates, the effectiveness of methylprednisolone may be reduced.
• With salbutamol - increased potential toxicity and effectiveness of salbutamol.
• With furosemide and thiazide diuretics, hypokalemia may be potentiated.
• When methylprednisolone is used together with oral anticoagulants or heparin, the anticoagulant effect increases or decreases.
• With cyclosporine - inhibition of the metabolism of methylprednisolone and cyclosporine.
• With erythromycin - there is a possibility of inhibition of the metabolism of methylprednisolone.

How to take the drug when planning pregnancy

Metypred for pregnancy planning is prescribed in a course of 2-3 months in a small dosage. The drug continues to be taken even after conception has occurred in order to consolidate pregnancy. Most often, the doctor prescribes ½ tablet of Metipred per day according to an individual regimen.

It is advisable to take the drug in the morning, after breakfast. The tablet is swallowed with clean water. It is not recommended to crush and chew the drug, or take it on an empty stomach - you can get gastritis or stomach ulcers.

In case of withdrawal, the amount of the drug is reduced gradually. Ignoring the withdrawal plan for Metipred causes severe side effects, including spontaneous miscarriage.

But there is no generally accepted drug withdrawal regimen. Each clinical case is individual, and the withdrawal process should be under the supervision of a physician. Whenever the dose of Metipred is reduced, it should be monitored by studying the level of androgens in the body.

Less commonly, the drug cannot be discontinued in full; the woman continues to take it throughout pregnancy, since, while discontinuing Metipred, she experiences symptoms of cervical dilatation, abdominal and lower back pain, and other symptoms of spontaneous abortion.

Sometimes the doctor prescribes treatment with Metipred for general reinsurance. If before pregnancy a woman’s hormonal levels were normal, and after conception an increase in androgen levels was detected, there may be no reason for the prescription of Metipred. In this case, you need to additionally consult another specialist on this issue.

Other drugs for IVF

In addition to hormones, other drugs are also used in the practice of reproductive medicine. The most common of them are:

• Adrenal hormones (Dexamethasone, Prednisolone or Cortisol) are often used to create immune bonds between the mother and the fetus she is carrying, as well as to reduce the level of androgens. Also, these drugs eliminate the development factors of the antigen to the hCG hormone, eliminating fetal hypoxia and preventing premature birth in a woman.
• Gonadotropin preparations for the physiological maintenance of pregnancy mechanisms. In this case, two types of these hormones are used: HMG and FSH preparations. The drugs most often used in clinics are Menopur, Elonva, Puregon, and Gonal-F. All these drugs are perceived by the body as natural and do not cause a reaction from the immune system. However, when taking them, there may be side effects (fatigue, anxiety, flatulence, etc.) Also, when taking gonadotropes, there may be a danger of ovarian hyperstimulation
• HCG preparations duplicate the natural hormones of the female body and contribute to the development of mechanisms for the safety of the fetus. The drugs Profasi or Pregnil are used as analogues of hCG.
• Blood thinning drugs (Aspirin, Heparin, Curantil) are often prescribed to pregnant women to maintain normal blood thickness and reduce platelet aggregation. These medications are prescribed under the control of a blood test. They ensure normal blood circulation in the uterus and placenta, preventing oxygen starvation of the fetus.
• Antihypoxic vitamins (folic acid, vitamins A, B and E, beta-carotene) are prescribed to provide vitamin support to the body of the mother and the unborn baby, maintaining their immunity at a sufficient level.

No pregnancy after IVF should be left to chance. Women with pathologies who, without modern technologies, would be doomed to lifelong infertility are turning to the in vitro fertilization technique. As a rule, in these difficult situations, the body does not have the resources to help a woman not only become pregnant on her own, but also maintain the pregnancy.

If a woman has already decided to undergo IVF, then without medical support in most cases she will not be able to endure the pregnancy that she has so dearly received. The main thing is to trust a good doctor and take all medications according to the regimen prescribed by the doctor. But all this is done so that a woman can experience the great happiness of finally becoming a mother.

What could be the consequences?

The instructions for the medicine can frighten many patients and especially worried expectant mothers. However, it is worth remembering that if you follow your doctor’s recommendations, you can protect yourself from unpleasant consequences.

Reviews from mothers who have already given birth to their babies indicate that the drug did not affect the course of pregnancy or the health of the babies. But this is all provided that the instructions and recommendations of specialists are strictly followed.

The main unpleasant effects that may occur when taking this drug include:

But it is worth noting that these are only possible side effects that do not always appear. At least, reviews from doctors indicate that the drug can solve the problems of hormonal imbalances and get pregnant faster.

How to replace the drug for expectant mothers

When a woman is found to be intolerant to the components of Metypred, the doctor selects a similar medicine. The list of analogues includes synonymous drugs with the same active substance, and functional analogues that differ from Metipred in composition, but perform the same tasks.

Prices in Moscow pharmacies for Metipred, manufactured in Finland, start at 167 rubles per pack. It is not always possible to save on analogues.

Table: Metypred analogues approved for pregnant women

Why take Metypred when planning pregnancy?

And you have to visit doctors and undergo examinations to identify the cause of female infertility. Very often, along with many other reasons, infertility can cause an increased amount of male hormones in the female body. If the examination confirms this particular cause of infertility, the doctor prescribes the woman to take Metipred when planning a pregnancy. This drug helps balance a woman’s hormonal levels.

This drug is most often prescribed as an anti-inflammatory, anti-shock, as well as anti-allergic and decongestant agent. When prescribing Metypred when planning pregnancy, its purpose is to treat hyperandrogenism, that is, an increased amount of male hormones in the female body. But this medicine is prescribed according to individual indications. The minimum dose of this drug is half a tablet. A woman is first prescribed this drug to help her become pregnant.

Source

Metipred instructions

Synthetic GCS. It has anti-inflammatory, antiallergic, immunosuppressive effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines.

Interacts with specific cytoplasmic receptors (receptors for GCS are found in all tissues, especially in the liver) to form a complex that induces the formation of proteins (including enzymes that regulate vital processes in cells).

The effect of methylprednisolone on protein metabolism: reduces the amount of globulins in plasma, increases the synthesis of albumins in the liver and kidneys (with an increase in the albumin/globulin ratio), reduces the synthesis and enhances protein catabolism in muscle tissue.

The effect of methylprednisolone on lipid metabolism: increases the synthesis of higher fatty acids and triglycerides, redistributes fat (fat accumulation occurs mainly in the shoulder girdle, face, abdomen), leads to the development of hypercholesterolemia

Source

Girls, please give me some advice! I have high testosterone and am now planning a pregnancy. The doctor said that I will take Metypred from the next cycle. I read the side effects and it became scary. especially from the endocrine system and metabolism:

suppression of the hypothalamic-pituitary-adrenal

renal axis, growth retardation, menstrual irregularities, amenorrhea, Cushingoid face, hirsutism, weight gain, decreased tolerance to carbohydrates, increased need for insulin and oral hypoglycemic drugs. I am extremely afraid of gaining excess weight, as I have lost 40 kg in a year. and during pregnancy, with proper nutrition, I plan to gain no more than 10 extra kg.

If the doctor has prescribed you to take hormone tests first, you don’t have to be afraid. and if side effects begin, immediately stop taking hormones. and side effects can occur when taking any medicine! and for some reason we are not afraid of this! and if you want a child, then nothing should stop you.

Anastasia, the Origitea medical center helped me (the golden needle of Dr. Mukhina)

Source

Women are often prescribed Metipred during pregnancy when there is a threat of miscarriage. Metipred is also prescribed when planning pregnancy to treat elevated levels of male hormones.

"Metypred" has anti-allergic, anti-inflammatory effects and suppresses the body's immune response to irritants, inhibits protein, carbohydrate, and lipid metabolism.

The drug reduces the number of immunocompetent cells at the site of inflammation, increases muscle tone and constricts blood vessels. "Metypred" during pregnancy, when used correctly, eliminates the risk of miscarriage.

Adults: 4–60 mg once daily or in smaller doses. The first dose is 12–40 mg per day, very rarely - up to 100 mg per day. Maintenance dose: 4–12 mg per day.

• Metipred injections can be prescribed: intramuscularly, intravenously, into the joint cavity, into the synovial bursae and vagina into the area of ​​skin lesions.

Adults for intramuscular administration are prescribed from 4 to 60 mg per day

Source

Features of the drug Metypred

Metypred is present quite often in the IVF protocol. Therefore, women are trying to figure out what role this drug plays in maintaining the desired pregnancy.

This medication is usually prescribed to women at the planning stage.

The product is indicated for elevated male hormones. In this case, there remains a high risk of miscarriage, so drug correction is required.

Normalization of a woman’s hormonal levels with Metypred

Metipred belongs to the group of synthetic glucocorticoids. This is a hormonal drug that is an analogue of prednisolone, but has better tolerance to the body with greater activity.

Its advantages are due to the fact that it almost does not retain sodium salts, which allows you to take Metypred for a longer period without significant side effects.

The main properties of Metypred are as follows:

1. anti-inflammatory;
2. antiallergic;
3. immunosuppressive.

Why Metypred is prescribed for IVF is not clear to everyone. Although the drug has a wide spectrum of action, during pregnancy its purpose is to correct the woman’s hormonal levels.

Composition of the drug

The main active ingredient of Metipred is methylprednisolone. Depending on the form of release, the drug may contain 4 or 16 mg of the active ingredient.

The active ingredient of Metypred is methylprednisolone

In addition to methylprednisolone, the tablets contain the following components:

• talc;
• magnesium stearate;
• starch;
• lactose monohydrate;
• gelatin.

Precautionary measures

Metypred is a hormonal drug, and all products containing artificial hormones have many side effects. The most dangerous thing is that artificial corticosteroids penetrate the placental barrier, so theoretically the drug can affect the child.

Side effects

Metypred has a systemic effect on the body, so side effects may occur in different organs:

Hormone synthesis. When taking an artificial corticosteroid, the activity of the adrenal glands is inhibited. In addition, taking steroids increases the risk of developing diabetes. Gastrointestinal tract. Most often, minor digestive disorders are observed. In rare cases, taking steroids can cause the development of stomach or intestinal ulcers. SSS. Sometimes there is arrhythmia, increased blood pressure

In case of heart failure, the medicine is prescribed with caution, as it can provoke an increase in symptoms.

• CNS. Quite often, headaches appear while taking medications. Effects such as loss of orientation in space, convulsions, and hallucinations are extremely rare. Depressive or paranoid symptoms may appear.
• Organs of vision. Visual impairment due to increased intraocular pressure, development of cataracts, predisposition to the development of infectious eye diseases.
• Exchange processes. Taking the drug may lead to increased sodium levels and deficiencies of potassium and calcium. The appearance of edema, weight gain, intense sweating.
• Leather. Various rashes may appear - acne, pyoderma. Increased tendency to develop stretch marks. The risk of developing skin fungal infections is very high.

Of course, not all women experience side effects. The likelihood of their occurrence increases with increasing daily dosage, as well as with increasing course duration.

Therefore, while taking it, you need to undergo regular tests; if signs of stabilization of hormonal levels appear, the doctor will adjust the dose or write a plan for gradual withdrawal of the drug.

How does it affect the fetus?

No connection has been identified between taking the drug at any time and the development of congenital defects in the fetus. In the case when the drug is prescribed to exclude miscarriage caused by hormonal changes, in the control group 98% of women gave birth to healthy full-term babies. However, the drug cannot be considered completely safe. This remedy should be taken only if there are serious indications and only under medical supervision.

So, Metypred during pregnancy is prescribed in the presence of hormonal imbalance associated with improper functioning of the adrenal glands and ovaries. The instructions warn that the drug can cause various side effects, so treatment should be carried out according to serious indications and under strict medical supervision.

Side effects of the drug Metypred and overdose

It is because of possible unpleasant side effects that many women are afraid to take Metypred when planning a pregnancy.

The annotation for the drug lists side effects manifested in the form of: nausea, vomiting, pancreatitis, bleeding, hiccups, flatulence, stomach ulcers, weight gain, arrhythmia, increased sweating, bradycardia, heart failure, increased blood clotting, thrombosis, muscle weakness, headaches pain, disorientation, hallucinations, depression, nervousness, anxiety, dizziness, insomnia, seizures, cataracts, weakened immunity, etc.

The list is frightening, but, as practice shows, these symptoms can only occur when taking large doses of the drug , which are prescribed to people for other serious illnesses. As for those planning a pregnancy, most often women noted weight gain, which returned to normal after stopping Metipred.

However, each organism is individual, therefore, if any of the listed symptoms occur, you must immediately contact your doctor to decide whether to discontinue the drug or select an analogue.

Description of the drug

Why are many women unable to get pregnant? Sometimes the cause of infertility is excessive production of male testosterone, which prevents conception. An excess of male hormones provokes frozen pregnancies and miscarriages.

The therapeutic effect of the drug is provided by the active substance - methylprednisolone. Metypred is an analogue of Prednisolone that does not cause a cumulative effect of sodium in the cells of the body. This is of key importance when taking the drug for a long time. In addition to correcting hormonal levels, Metypred also has other effects on the body:

• weakens strong immune defenses;
• stops inflammatory processes;
• has an antihistamine effect.

Why do pregnant women need weakened immune defenses? The immune system perceives the embryo as a foreign object and tries to get rid of it. In healthy women, the immune mechanism weakens automatically; in patients with hormonal disorders, the weakening is caused by taking medications.

Medicine release form:

• pills;
• powder;
• injection.

Since this medicine is a potent drug, the prescription and dosage are determined only by the treating gynecologist. Metypred is also prescribed after successful conception to preserve the embryo in the uterine cavity. The dosage in this situation is minimal.

Appointment for planning and IVF

There are many pathologies of the reproductive organs and concomitant diseases that negatively affect reproductive function. This drug can eliminate many of them. It helps restore hormonal levels, which is the main reason for non-pregnancy. Prescribed for the following factors:

• the need to eliminate the inflammatory process;
• the presence of an increased amount of male hormones;
• hormonal imbalance:
• with uterine fibroids;
• presence of a diagnosis of recurrent miscarriage;
• the need for complex treatment of diseases.

For whom is Metipred contraindicated?

For the use of a hormonal drug for a short course, the only contraindication is an allergy to methylprednisolone, as well as to Metypred’s excipients, including:

• lactose monohydrate;
• corn starch;
• magnesium stearate;
• gelatin;
• talc.

It is clear that due to the presence of lactose, the medicine is dangerous for women suffering from lactase deficiency.

Since Metypred suppresses the immune system, they try not to prescribe the drug to women who have contracted infections - otherwise bacteria and viruses will take over the body, infect organs, and even infect the fetus.

It is not advisable to use Metipred for patients with Cushing's disease, in which the adrenal cortex already produces an excess amount of hormones.

With great precautions, the drug is prescribed for:

• pathologies of the digestive tract - gastritis, stomach ulcers, ulcerative colitis;
• a number of infections - herpes, systemic mycosis, chickenpox, tuberculosis; AIDS and HIV infection;
• diabetes mellitus;
• obesity;
• pathologies of the thyroid gland;
• severe liver or kidney failure;
• osteoporosis;
• acute psychosis;
• glaucoma;
• polio;
• convulsions;
• chronic heart failure.

Adverse reactions

Almost every system of the body comes under the influence of the drug, which is accompanied by the development of various negative reactions:

Under the influence of the drug, fat metabolism changes, as a result, fat is redistributed throughout the body - the face is rounded, the stomach and shoulder girdle increase in volume. A woman gains extra pounds, sweats a lot, suffers from swelling; Calcium and potassium are washed out of the body, and sodium, on the contrary, is retained.

One of the unpleasant consequences of taking Metipred is rapid weight gain

How Metypred interacts with other medications

The drug is not “friendly” and, when taken simultaneously with other drugs, often suppresses their effect; an aggressive effect on the pregnant woman’s body is also possible.

Here are examples:

• if Metypred is taken together with Paracetamol, liver function may be impaired;
• simultaneous intake with vitamin D will reduce the absorption of calcium;
• drugs with acetylsalicylic acid (Cardiomagnyl, Thrombo ACC are allowed for pregnant women) are eliminated from the body faster when taken together with Metipred;
• diuretics, which are used to remove excess fluid from tissues, together with Metipred, accelerate the excretion of potassium and provoke heart failure;
• the combined use of Metipred with anticoagulants that reduce blood density (for expectant mothers this is Fraxiparine, Clexane), in some cases increases, in others decreases the effect of anticoagulants;
• if Metypred is taken simultaneously with medications containing sodium, swelling and hypertension cannot be ruled out;
• since the drug itself weakens the immune defense, its use with immunosuppressants reduces it too much; the use of Metypred with an immunosuppressant such as Cyclosporine occasionally provokes seizures.

If a pregnant woman is prescribed a Metipred injection, the solution is administered separately from other drugs.

Characteristic

Metypred is one of the hormonal drugs, an analogue of which is Prednisolone. According to some information, it is more effective in use. Metypred cannot, like its analogue, retain sodium in tissues. In the case of long-term therapy, this fact is very important.

The medicine is an antihistamine, antiphlogistic and immunosuppressant with a wide range of effects on the body. Forms of release of the pharmacological agent: tablets, powder, injections.

Due to the fact that the drug has a number of contraindications, you should consult a doctor to start taking it. Metypred is used during in vitro fertilization (IVF) to treat the absence of pregnancy due to increased androgen levels in the patient.

If infertility treatment was successful and a woman became pregnant after embryo implantation while taking Metypred, its use should not be stopped. It is worth reducing the dosage after consulting your doctor. Since sudden refusal of the drug can lead to miscarriage.

Metipred is a specific drug that is used not only to treat infertility due to increased levels of male hormones in women, but also for:

• therapy for excessive secretion or high activity of androgens in women;
• blocking the activity of the immune-pituitary system in the IVF protocol;
• malignant tumors;
• benign tumors;
• multiple sclerosis;
• Libman-Sachs disease.

Why is Metipred prescribed for IVF? important details

Unfortunately, not every representative of the fair sex is able to experience the joy of motherhood. This happens for many reasons, but they are not always of the nature of force majeure. First, you need to understand what exactly prevents you from conceiving and carrying a baby. As soon as the answer to the question is found, the obstetrician-gynecologist begins work.

One of the ways to become a mother is artificial insemination technology - IVF.

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In this case, the drug "Metypred" has a positive effect on the process:

• Normalizes testosterone levels;
• Normalizes the concentration of antibodies to hCG in the blood;
• Reduces the likelihood of embryo rejection during IVF.

The artificial insemination procedure is designed to give a chance to those women who, for one reason or another, cannot become pregnant naturally. Dosed use of this medication helps increase the chance of a positive outcome.

Application

When a woman is planning a pregnancy, she should start taking the drug three months before conception. After fertilization, you need to take half a tablet to consolidate the result. All dosages are prescribed individually, based on the patient’s weight and condition.

It is recommended to take Metypred at the same time in the morning after breakfast. The tablet should not be chewed, made into powder, or taken on an empty stomach (as this could lead to an ulcer); it should simply be swallowed with water.

If the patient wants to stop taking the drug, then the dosage should be slowly reduced. Since incorrect cessation of medication use entails a number of consequences, in particular miscarriage. Discontinuation of Metipred and its analogues should be accompanied by monitoring the concentration of male hormones in the woman’s body.

Sometimes, due to the appearance of symptoms (pain in the abdomen, lower back), you cannot stop taking the corticosteroid until the end of pregnancy.

Metypred is also prescribed after pregnancy, in case of sudden changes in hormonal levels (increase in male hormones). In such a situation, it is worth going to see another doctor so as not to harm yourself and the child.

Why is Metipred prescribed for IVF? A similar question often arises among patients who use the in vitro fertilization program.

The main function of the drug is to block the pituitary gland and the activity of the immune system. A corticosteroid is prescribed to a woman 2-3 days before the transfer of a fertilized egg. The medicine helps increase the chances of successful embryo implantation.

Metipred and its analogues are prescribed to almost all women who decide to use an IVF program for infertility treatment, since the drug plays a big role in successful embryo implantation. Metypred is used after embryo transfer to prevent miscarriage.

Long-term use of any drug leads to the appearance of negative symptoms. Metipred is no exception. The body's response to medications depends on the dosage and how long the course of treatment lasted.

Hypertension, diabetes mellitus, decreased functioning of paired endocrine glands, decreased appetite, indigestion, bloating, inflammation of the pancreas, disturbances of consciousness and sleep, bipolar affective disorder, cataracts, tissue atrophy - these are only some of the possible consequences of taking the drug.

There may be a predisposition to angioedema, allergies and anaphylactic shock. With small dosages there is no need to think about side effects. Since they appear when the norm increases and is taken for a long time in this mode.

Main characteristics of the drug

The main component of Metypred is methylprednisolone, it is recommended to drink it before conception to reduce the level of androgens in the blood and suppress their excessive secretion.

The drug is characterized by antiphlogistic and antihistamine properties and is a broad-spectrum immunosuppressant. Hormonal medicine is produced in the form of powder, tablets and injection solution.

Metypred for IVF: why the drug is prescribed

It is worth noting that Metypred in gynecology is used mainly for elevated testosterone and infertility that has developed against this background, as well as in cases of frequent miscarriages. Gynecologists recommend drinking Metypred during in vitro fertilization (IVF) after embryo transfer in order to successfully attach the zygote itself to the uterine mucosa.

In IVF, the drug is prescribed for:

• Maintaining pregnancy with a history of multiple miscarriages
• Activation of the immune system before the IVF protocol
• Elimination of swelling and allergic reactions
• Relief of inflammation
• Increasing the likelihood of pregnancy in the case of various uterine pathologies
• Treatments for hyperandrogenism
• Conducting therapeutic therapy aimed at eliminating hormone-dependent tumors.

Before embryo transfer, Metypred is prescribed to be taken several days before the intended procedure. Thanks to this, the hormonal drug increases the chances of implantation of the zygote.

Metypred during pregnancy is taken only after a doctor’s prescription, if, according to test results, hormonal support is necessary for the normal development of the fetus.

Effect of the drug

Metypred plays an important role during pregnancy . Doctors prescribe it to be on the safe side when they see a deterioration in hormonal levels. But you need to take Metypred very carefully during pregnancy.

It works positively only if you follow the recommendations of your doctor. The correct meaning, compliance with instructions and recommendations, will serve to conceive a child . Almost all women are prescribed medication. When doctors have identified contraindications to the components of the drug, it is recommended to refuse IVF.

Many patients cannot understand why it is prescribed, because it promotes weight gain. Doctors believe that the drug is an integral part of IVF conception, and the weight will begin to normalize almost immediately after stopping the drug. Metypred helps in most cases, but there are exceptions.

Metipred when planning pregnancy

For a variety of reasons, women can develop infertility. And then planning for conception grows from a pleasant moment into a whole problem, leading to stress, the development of depression, constant visits to doctors, psycho-emotional stress, and anxiety. And then the married couple forgets that they need to enjoy life and begins to exist in a constant standby mode. You should not do this even if your doctor has diagnosed you with infertility. It is much easier and better to start taking care of yourself, get tested and undergo examinations to find out the causes of infertility. Often, the reason for non-occurrence of pregnancy is an excess of male hormones in a woman’s body. If you have a hormonal imbalance, do not think that the diagnosis is your death sentence. To achieve pregnancy and correct hormonal levels, doctors quite often prescribe Metypred

Appointment for planning and IVF

There are many pathologies of the reproductive organs and concomitant diseases that negatively affect reproductive function. This drug can eliminate many of them. It helps restore hormonal levels, which is the main reason for non-pregnancy. Prescribed for the following factors:

• the need to eliminate the inflammatory process;
• the presence of an increased amount of male hormones;
• hormonal imbalance:
• with uterine fibroids;
• presence of a diagnosis of recurrent miscarriage;
• the need for complex treatment of diseases.