Magnerot for atrial fibrillation - Treatment of hypertension

Pregnancy is a special period in the life of every woman. And not always accompanied exclusively by joy and happy anticipation of the long-awaited baby: pregnancy is often aggravated by various kinds of complications that can be caused, among other things, by deficiency conditions.

It is known that as the baby grows and develops in the womb of the mother, the woman’s need for useful and nutritious substances increases significantly. During pregnancy, the need for such a microelement as magnesium also increases, the deficiency of which is not always possible to compensate only by consuming foods rich in this valuable substance. And in this case, doctors may raise the issue of using magnesium preparations, often giving preference to the drug Magnerot.

Magnesium is one of the microelements that takes part in metabolism, regulates contractions of the heart muscle, and facilitates the body's reactions in stressful situations. With a lack of magnesium, the need for which increases during pregnancy, the consequences can be dangerous for both mother and baby.

Thus, magnesium deficiency in the mother provokes cramps (primarily in the calf muscles), can cause spontaneous abortion or premature birth, and lead to the development of preeclampsia or eclampsia. For the fetus, a lack of magnesium can be dangerous due to the development of chromosomal abnormalities and embryonic malformations, cause developmental retardation or provoke fetal edema.

Thus, the first indications for which Magnerot is prescribed during pregnancy are: the threat of miscarriage or premature birth, as well as the risk of developing preeclampsia or eclampsia. In addition, Magnerot during pregnancy can be prescribed as a prophylaxis and to eliminate the possible consequences of stressful conditions.

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Effect of the drug

Maintaining the level of magnesium in the body is necessary for the well-being of the expectant mother and the normal intrauterine development of the child. A deficiency of this element can cause indigestion, cramps, spasms of the uterine muscles, eclampsia and even spontaneous miscarriage. In addition, it can cause fetal malformations. Magnerot is a drug that, due to the presence of magnesium and orotic acid, helps restore normal levels of microelements in the body, and also has a positive effect on the course of pregnancy.

Taking this drug can prevent:

  • increased blood pressure;
  • calf cramps;
  • premature labor pains;
  • disturbance of psycho-emotional state;
  • delayed fetal development.

Magnesium also has a positive effect on heart function, and orotic acid saturates cells with useful substances, which is very important for the active development of the fetus.

Magnerot during pregnancy

The state of pregnancy can provoke various chronic diseases. This is because during this period the female body begins to experience a double load on all organs and to maintain vital functions additional sources of vitamins and various minerals are required; if they are deficient, deficiencies of various substances appear that affect the functioning of the entire body. However, not all substances can be obtained from food, much less quickly restored to normal. For this purpose, medications and complex vitamins necessary for the expectant mother are used. One of these pharmaceuticals is Magnerot.

Why is Magnerot needed?

Magnerot is a medicine that affects tissue metabolism processes in the body. The main component of the product is magnesium orotate dihydrate. Magnesium plays a very important role in the human body. It is an active participant in protein, energy, carbohydrate or lipid metabolism, and does not ignore nucleic acids. Magnesium is able to regulate neuromuscular agitation by inhibiting neuromuscular transmission. Magnesium is able to regulate the contractile function of the myocardium and maintains normal cardiomyocyte functions. Thus, magnesium contained in the drug together with orotic acid stimulates cell growth, increases the body’s resistance to stress and regulates metabolism. In addition, it fixes magnesium ions in the intracellular space and in bone tissue. Its deficiency can cause serious disorders in both the body of the mother and the child. In a pregnant woman, magnesium deficiency causes convulsions and provokes miscarriage, and in a baby it can cause changes in chromosomes and lead to deviations in the development of the child. In addition, a lack of this drug can cause eclampsia or preeclampsia.

The indications for the use of this drug are very serious and you should not prescribe it yourself. In order for the doctor to have grounds for prescribing it, it is necessary to first pass a biochemical test for the presence of magnesium in the blood. If there is a need to take such a drug, the course of therapy lasts from a month until the birth. Usually the drug is prescribed in stages. The first week the patient takes the drug 2 tablets 2 or 3 times a day an hour before meals or four hours after meals; in all subsequent times the number of tablets is reduced to 1 tablet 3 times a day. The drug should be taken with a small amount of still water.

In almost all cases, this drug does not cause any problems for patients, but there are exceptions to every rule.
In this case, the medicine cannot be used by people who have problems with bradycardia or kidneys and liver. Intolerance to individual components included in the drug can also cause an allergic reaction. Digestive disturbances such as constipation or diarrhea may occur. In these cases, the attending physician will either replace the drug with another drug or adjust the dose. When using Magnerot, you must adhere to the storage rules described on the packaging and strictly monitor the expiration date. The shelf life of the drug is no more than five years. Author of the publication: Valeria Samoilova

Indications for use

Magnerot is prescribed as a preventive drug during pregnancy, but you can start taking it only after examination by a doctor. Magnesium deficiency is detected through a biochemical blood test, based on the results of which the use of Magnerot may be recommended. There are a number of symptoms that indicate a lack of magnesium and, if they occur, you should immediately contact a specialist. Among them:

  • chronic fatigue;
  • frequent tremors;
  • dizziness;
  • feeling of anxiety;
  • high blood pressure;
  • muscle cramps;
  • disturbances in heart rhythm.

Self-administration of Magnerot is strongly not recommended, because an excess of microelements can have the same negative impact on the development of the fetus as their deficiency.  

Magnesium is needed by the body for:

  • normal bowel function, prevention of constipation and chronic intoxication caused by them;
  • preventing the formation of kidney stones, gall bladder and gout;
  • reducing the risk of developing diabetes (when consuming 300-365 mg of magnesium, tissue sensitivity to insulin increases);
  • prevention of atherosclerosis and hypertension;
  • healthy heart rate;
  • strengthening bones, preventing osteoporosis;
  • increasing the body's resistance to stress;
  • healthy immunity and a reduced risk of certain cancers (magnesium may reduce the risk of pancreatic cancer, according to a publication in the British Journal of Cancer);
  • energy production (ATP) and absorption of phosphorus, potassium, vitamins B, C, E in the intestines.

Instructions for use

As a rule, the use of Magnerot occurs in two stages - in the first, the body is actively saturated with magnesium, and the second is aimed at maintaining its normal level. Standard course of taking the drug:

  1. 2 tablets three times a day for 7 days;
  2. 1 tablet three times a day for 4 weeks.

Depending on the characteristics of the body, the doctor may prescribe an individual course. You cannot increase or decrease the dose of the drug on your own - this may negatively affect the effect of taking it.

V.A. Lebedev, I.V. Ignatko, V.M. Pashkov

Department of Obstetrics, Gynecology and Perinatology, First Moscow State Medical University named after.
I.M. Sechenova The article discusses the role of magnesium ions and the prospects for using magnesium preparations (Magnerot) in the complex treatment of various types of pathology in early pregnancy, including threatened miscarriage in the first trimester. Key words: pregnancy, first trimester, threatened miscarriage, magnesium.

Information about the author: Vladimir Aleksandrovich Lebedev, Doctor of Medical Sciences, Professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Medicine, First Moscow State Medical University named after. I.M.Sechenova

Contraindications and side effects

The use of Magnerot is not recommended in the presence of diseases of the kidneys and genitourinary system. Also, you should not take this drug if you have an individual intolerance to its components. As for side effects, they include stool disturbances and the possibility of allergic reactions. If diarrhea develops after several days of taking Magnerot, this may be related to the dosage of the drug and you should consult a doctor to adjust it. Allergic reactions are a direct indication for stopping the course. Before you start taking it, you should read the instructions from the manufacturer, check the expiration date of the drug and strictly follow the specialist’s instructions.

Precautionary measures

Magnerot, like other drugs containing magnesium, is prohibited for use in the following conditions:

  • the presence of kidney stones;
  • renal failure:
  • severe liver disease (cirrhosis);
  • individual intolerance to the drug.

Advice! It should be borne in mind that the tablets contain lactose, therefore Magnerot is prohibited for use in conditions associated with intolerance to this substance.

Side effects

Magnerot is almost always well tolerated, but the development of allergic reactions cannot be ruled out. In rare cases, the following may occur:

  • stool disorder;
  • the appearance of a rash on the skin;
  • abdominal discomfort.

The optimal balance of vitamins and minerals in a woman’s body is important for the development of the fetus

Overdose

If a woman has healthy kidneys, then even if the dosage is chosen incorrectly, no unpleasant consequences will develop. Excess magnesium will simply be removed from the body. If renal function is impaired in case of overdose, toxic reactions are observed. Symptoms of magnesium poisoning:

  • a sharp decrease in pressure;
  • vomit;
  • depressed mental state;
  • slower reactions;
  • in severe cases - coma and cardiac arrest.

When signs of magnesium poisoning appear, a process of rehydration and diuresis is carried out. In case of renal failure, hemodialysis is additionally performed.

Analogs

The following drugs are analogues of Magnerot on the Russian pharmaceutical market:

  • Additiva magnesium effervescent tablets;
  • Vitrum Mag chewable tablets;
  • Magwit capsules;
  • Magne B6 tablets and oral solution;
  • Magnelis B6 tablets;
  • Magne Positive tablets;
  • Magne Express granules for resorption;
  • Magnesium-Diasporal 300 granules for the preparation of solution for oral administration;
  • Magnesium plus tablets;
  • Magnesium plus B6.

Before using analogues, consult your doctor.

Literature

1. Barashnev Yu.I. Perinatal neurology. Triad-X, 2001. 2. Gorodetsky V.V., Talibov O.B. Magnesium preparations in medical practice (Small Encyclopedia of Magnesium). M.: Medpraktika-M, 2003. 3. Gromova O.A. Magnesium and pyridoxine: basic knowledge. M.: 2006. 4. Kosheleva N. G. The role of hypomagnesemia in obstetric pathology and methods of its correction. Vestn. Ross. assoc. obstetricians-gynecologists. 1999; 1:42–46. 5. Kosheleva N.G., Arzhanova O.N., Pluzhnikova T.A. Miscarriage: Etiopathogenesis, diagnosis, clinic and treatment, St. Petersburg: 2003; 70. 6. Kudrin A.V., Gromova O.A. Microelements in neurology. M.: GEOTAR-Media, 2006. 7. Pathophysiology. Course of lectures: textbook / Ed. P.F. Litvitsky. M.: Medicine, 1995. 8. Mezhevitinova E.A., Akopyan A.N. Magnesium deficiency conditions in gynecological practice: clinical assessment and methods of correction. Issues of gynecology, obstetrics and perinatology. 2007; 6 (4): 91–98. 9. Ninkova E., Vladova D., Marinova M. The drug Magnerot in the treatment of threatened abortions and premature births. Bulgarian doctor. 1997; 82: 8: 4. 10. Polushkina E.S., Shmakov R.G. Use of magnesium in obstetrics. Attending doctor. 2010; 11:33–39. 11. Savelyeva G.M., Sichinava L.G. et al. Improving perinatal outcomes is one of the main problems of modern obstetrics. Russian Bulletin of Obstetrician-Gynecologist. 2008: 6: 56–60. 12. Sidelnikova V.M. Use of Magne B6 in a miscarriage clinic. Obstetrics and gynecology. 2002; 6:47–48. 13. Sidelnikova V.M. Habitual pregnancy loss. Triad-X, 2004. 14. Strizhakov A.N., Ignatko I.V., Martirosyan N.T. Principles of complex treatment of threatened miscarriage in women with recurrent miscarriage. Issues of gynecology, obstetrics and perinatology. 2008; 7: 2. 15. Chekman I.S., Gorchakova N.A., Nikolai S.L. Magnesium in medicine. Chisinau, 1992. 16. Altura BM Basic biochemistry and physiology of magnesium: a brief review. Magnesium & Trace Elements. 1991; 10: 167–171. 17. Ebel H., Gunther T. Magnesium metabolism: a review. J. Clin. Chem. & Clin. Biochem. 1998; 18: 257–270. 18. James MFM Magnesium in obstetrics. Best Pract & Res Clin Obst & Gyn. 2010; 24:3:327–337. 19. Planells E, Montellano MA et al. Vitamin B6 and B12 and folate status in an adult Mediterranean population. Eur J Clin Nutr. 2003; 57:775–854. 20. Institute of medicine (US). Standing Committee on the Scientific Evaluation of dietary reference intakes. Food and nutritional board. Diatary reference intakes for folate, other B viatamins and choline. Washington DC: National Academy press. 1999; 150–195.

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