Femoston when planning pregnancy. Femoston, instructions for use

If numerous attempts to get pregnant remain unsuccessful or the embryo that has barely had time to conceive dies in all cases, a woman is ready to go to great lengths to defeat stubborn physiology. As a rule, women dreaming of motherhood can expect numerous examinations, long-term treatment and careful pregnancy planning. The main point of such therapy is the use of a number of hormonal drugs. The doctor decides which one to prescribe based on the results of the examination of the patient and the characteristics of her physical condition. Many people today are prescribed Femoston when planning pregnancy. We will focus on the specifics of treatment with this drug.

Femoston 2/10 when planning pregnancy: instructions

Even after a quick reading of the instructions for the drug, many questions arise, since the manufacturers of the drug warn: Femoston should not be taken when planning and during pregnancy, as well as during breastfeeding. How can we understand this? Believe me, the point here is not the negligence and incompetence of doctors, but the peculiarities of the female reproductive system. Let's understand everything in order.

Femoston is a two-phase combination drug of hormonal origin. It contains analogues of natural female sex hormones - estradiol (2 mg) and dydrogesterone (10 mg). These substances stabilize the body's hormonal levels, which become out of order with the approach of menopause. Estradiol compensates for the lack of estrogen, and dydrogesterone stimulates the growth of endometrial tissue. The drug package contains 28 tablets: one half is pink, the other half is light yellow. The main task of Femoston is to reduce the signs of menopause and help a woman endure menopause more comfortably. In this regard, the main indications for the use of these tablets are:

• hormonal replacement treatment of various disorders caused by menopause, which occurred as a result of surgery or for other reasons;
• to prevent osteoporosis, which usually develops in postmenopause.

The drug has several dosages: 1/10, 2/10, 1/5. To prescribe each of them, there is an individual scheme that strictly correlates with certain dates of the monthly cycle, and in the absence of menstruation - with the expected days of its onset.

What kind of remedy?

Femoston is a combined hormonal drug that contains two types of female sex hormones:

• estrogen,
• dydrogesterone.

Three types of the product are available, differing in the content of active substances. All options are available in the form of tablets, 28 pieces per pack. Varieties:

• 1:5 – a preparation in which all pills have the same composition and appearance (orange shell). The pill contains 1 mg of estradiol and, accordingly, 5 mg of dydrogesterone.
• 1:10 – in this version, the pills have different colors and compositions, white pills contain only estradiol (1 mg), gray pills, in addition to estradiol (1 mg), also contain dydrogesterone (10 mg).
• 2:10 – this option is similar to the previous one, it differs by doubling the amount of estradiol (2 mg), the content of dydrogesterone is not increased and is 10 mg. The color of the pills is pink and yellow.

When is Femoston 2/10 prescribed when planning pregnancy?

If for unknown reasons a woman is unable to get pregnant, the doctor will certainly send his patient for a comprehensive examination to clarify the real picture of her health condition. As part of such a diagnostic program, women are shown a dynamic ultrasound procedure, as a result of which the parameters of the endometrium of the uterus are determined, in particular its thickness. If this indicator turns out to be too small (about 7 - 8 mm at the end of the first phase of the monthly cycle), this indicates that ovulation is disrupted and conception may not occur. The main indicator for prescribing Femoston to ensure successful conception is the so-called hypoestrogenic state, which leads to thinning of the endometrial tissue.

Side effects

The category of side effects that often occur in connection with the use of Femoston includes: pain (headaches, in the abdomen, in the pelvic area), nausea, migraine attacks, flatulence, leg cramps, increased sensitivity and/or tenderness of the mammary glands, metrorrhagia, the appearance of bloody vaginal bleeding after menopause, asthenia, decrease/increase in body weight.

With a frequency of 1/1000-1/100 during clinical studies, the following phenomena occurred:

• vaginal candidiasis;
• depression;
• an increase in the size of uterine fibroids ;
• change in libido ;
• increased nervousness;
• DVT, PE;
• dizziness;
• gallbladder disease ;
• backache;
• allergic reactions on the skin, accompanied by itching, hives , rashes;
• dysmenorrhea;
• ulcerative defects on the cervix;
• the appearance of cervical discharge;
• peripheral edema.

In rare cases (with a frequency of 1/10000-1/1000), drug therapy was accompanied by:

• intolerance to contact lenses;
• functional liver , which often manifest themselves in the form of asthenia , malaise, abdominal pain, jaundice ;
• increased curvature of the cornea;
• enlargement of the mammary glands;
• premenstrual tension syndrome.

In isolated cases, the drug can provoke the development of chorea , hemolytic anemia, stroke, myocardial infarction, vascular purpura, vomiting, erythema nodosum or multimorphic, melanopathy or chloasma (often persisting even after discontinuation of the drug), angioedema , hypersensitivity reactions, worsening of porphyrin disease .

In addition, in connection with treatment with estrogen-progestagen drugs, women sometimes develop neoplasms (benign, malignant or of unknown etiology), the size of progestogen-dependent tumors fibrocystic lesions of the mammary glands appear of triglycerides in the blood plasma and the concentration of thyroid hormones increase ; arterial hypertension , acute arterial , peripheral vascular disease, varicose , dyspepsia , pancreatitis (against the background of pre-existing hypertriglyceridermia), systemic lupus erythematosus , cystitis-like syndrome , urinary incontinence develop epilepsy worsens , signs of dementia .

Femoston 2/10 when planning pregnancy: mechanism of action

Recently, the intended purpose of the hormonal drug has changed somewhat: doctors are very successfully using the properties of Femoston to eliminate internal disorders that do not allow a woman to conceive a child. The main causes of this problem are estrogen deficiency and thinning of the endometrium. And the use of Femoston, as stated in the instructions, causes growth of the uterine mucosa and, therefore, contributes to its thickening. In other words, the drug “for menopause” creates the most favorable conditions for the fertilized egg to attach to the endometrium of the uterus.

When planning pregnancy, the dosage of Femoston 2/10 is most often used. These numbers indicate the hormone content of the tablet. The first indicator indicates the amount of estrogenic substance (2 mg of estradiol), and the second - gestagenic (10 mg of dydrogesterone). The percentage of estrogen in the drug is very small, so Femoston, like combined contraceptives, does not suppress the onset of ovulation.

Dydrogesterone is an analogue of natural progesterone

Pharmacodynamics and pharmacokinetics

Femoston is a combined hormonal drug used to eliminate the symptoms of estrogen deficiency and treat DUB - dysfunctional uterine bleeding .

The estradiol contained in the drug is identical to endogenous estradiol . The drug is used to replenish estrogen after the onset of menopause and effectively treats vegetative and psychoemotional disorders associated with menopause , accompanied by:

• hyperhidrosis;
• tides;
• involution of the mucous membranes and skin, and especially the mucous membranes of the urogenital tract (in particular, the vaginal mucosa, due to which a woman begins to experience discomfort during sexual intercourse);
• increased nervous excitability;
• headaches and dizziness;
• sleep disorders;
• loss of bone mass or osteoporosis (especially if certain risk factors are noted - long-term treatment with glucocorticosteroids in the recent past, early onset of menopause , asthenic type of build, smoking, etc.).

Estradiol also helps reduce the concentration of total cholesterol and low-density lipoproteins, while simultaneously increasing the concentration of high-density lipoproteins.

The action of the gestagenic component of the drug - dydrogesterone - is aimed at stimulating the onset of the secretory phase of the endometrial cycle, and also reduces the risk of carcinogenesis and endometrial hyperplasia associated with the influence of estrogen .

Dydrogesterone does not have androgenic estrogenic , glucocorticosteroid or anabolic effects . To ensure the maximum preventive effect of hormone replacement therapy (HRT), treatment is recommended to begin as early as possible after the onset of menopause .

After taking p/os, estradiol is easily absorbed. Biotransformation of the substance occurs in the liver ; the metabolic are estrone and estrone in the form of sulfate . Estradiol and estrone glucuronides are eliminated from the body primarily in the urine.

Dydrogesterone is also rapidly absorbed from the digestive tract after oral administration. The substance is completely biotransformed, the main product of metabolism is 20-dihydrodydrogesterone. Metabolites excreted mainly through urine.

The half-life of dydrogesterone is from 5 to 7 hours, its main metabolite is from 14 to 17 hours, the substances are completely eliminated after 72 hours.

Femoston treatment regimen when planning pregnancy

To improve the condition of the “thin” endometrium, tablets of the drug should be taken from the first day of the monthly cycle. The treatment period is 28 days. Femoston 2/10 is taken 1 tablet per day continuously. Eating does not affect the time you take the medicine, but it is best to take the tablet at the same time of day. Tablets containing estrogen are taken during the first 2 weeks of treatment, using them to correct the first phase of the cycle. This stage of therapy stimulates the division of cells in the inner lining of the uterus. For the next 2 weeks, tablets with dydrogesterone are taken; they provide secretory transformation of the endometrium for the successful attachment of a fertilized egg upon pregnancy. Femoston has proven itself well in simulating a disordered monthly cycle.

In most cases, doctors practice treatment with Femoston and Duphaston when planning pregnancy. The need for complex therapy is explained by the fact that women treated with Femoston need additional stimulation of the second phase of the monthly cycle, therefore, from the 14th day of treatment, the patient is prescribed Duphaston 1 tablet 2 times a day for two weeks. The latter contains dydrogesterone as a gestagen substance, therefore, in combination with Femoston, this component has an enhanced positive effect on the female body.

In addition, there is an assumption that Femoston revives ovulation in a woman’s body, in the absence of which, as is known, it is impossible to get pregnant (and this despite the fact that during treatment with the drug, ovulation in the vast majority of cases does not occur, but comes after its discontinuation) .

It is important! Treatment with Femoston cannot be stopped if there are still tablets left in the package. Abrupt withdrawal of a potent drug can cause hormonal imbalance, which will result in bleeding of varying intensity and, naturally, make pregnancy impossible.

Contraindications

The drug is not prescribed:

• women who have been diagnosed with malignant estrogen- or progestogen-dependent tumors , as well as if these diseases are suspected;
• patients with diagnosed or suspected breast cancer ;
• with vaginal bleeding of unspecified origin;
• with untreated hyperplasia (pathological growth) of the endometrium ;
• venous thromboembolism detected at the moment or noted in the anamnesis (including DVT and PE);
• if the patient has certain thrombophilic disorders (including thrombophilia associated with deficiency of antithrombin , coagulation protein C or its cofactor - protein S );
• for thromboembolic arterial diseases , including angina pectoris or myocardial infarction (both in the active stage and in cases where the disease was suffered in the recent past);
• in case of active liver , and also if the patient’s liver biochemical parameters ;
• with porphyrin disease ;
• if you are aware of individual intolerance to estradiol , dydrogesterone or auxiliary components of Femoston;
• children and adolescents under 18 years of age;
• during pregnancy (both established and suspected pregnancy);
• during lactation.

Femoston when planning pregnancy: side effects

Femoston is a potent drug that has a significant effect on many organs and systems of the female body. If the following alarming signs appear during treatment with Femoston, the patient should immediately notify the doctor who is seeing her:

• from the reproductive system - swelling and engorgement of the breast, pain in the lower abdomen, uterine bleeding;
• from the gastrointestinal tract – nausea, vomiting, diarrhea, liver dysfunction;
• from the central nervous system - depressed state, depression, headaches;
• allergy;
• in rare cases - decreased sexual desire, the appearance of tumors in the mammary gland.

Contraindicated for whom

Contraindications for use:

• suspicion of pregnancy;
• oncology;
• diabetes;
• epilepsy;
• lumps or nodes in the mammary glands;
• endometriosis;
• thrombosis;
• systemic lupus erythematosus;
• endometrial hyperplasia;
• arterial hypertension;
• bronchial asthma.

It is important to stop use if you have jaundice or other liver problems. High blood pressure, migraines and poor health are also indications for discontinuing or replacing the drug.

Reviews from doctors about the use of Femoston when planning pregnancy

Treatment with Femoston in order to increase the chances of getting pregnant looks quite justified. However, this practice also has many opponents. Gynecologists motivate their distrust with the following arguments:

1. Do not forget that Femoston is a hormonal drug. Its dosage for a woman who soon wants to become a mother is very high, and this may in one way or another affect the condition of the fetus.
2. One can argue about the effectiveness of treatment: conception, as a rule, occurs after discontinuation of the drug after prolonged use, and not all patients expect positive results.
3. Not all women tolerate Femoston well. Almost every patient notices one or more side signs of treatment, and Femoston, as we have already seen, has many of them. Almost always, treatment with hormonal medication is accompanied by dizziness, abdominal pain, discomfort in the pelvis and chest, flatulence, nausea, irascibility, and disruption of the menstrual cycle.

Gynecologists who consider planning a pregnancy while taking Femoston unacceptable believe that to stimulate conception, it is best to take an individually selected estrogen-containing drug in the first phase of the cycle, and Duphaston, which contains dydrogesterone, in the second phase.

What do the patients themselves say about Femoston? Many women claim that thanks to taking this hormonal medication, their menstrual cycle has normalized. There are also reviews of pregnancy due to the use of Femoston: conception occurred immediately after discontinuation of the hormonal drug. There are also openly negative opinions. Some patients, while taking Femoston, noted a sharp increase in weight and the appearance of swelling in their legs. We remind you once again that if you notice any strange symptoms during treatment with Femoston, you should consult a doctor for clarification of the situation.

As you can see, treatment with Femoston is a very controversial issue, with many pros and as many cons. A woman who is trying to get pregnant despite all past failures needs to remember the main thing: she is not obliged to blindly follow the recommendations of her doctor. The prescription of Femoston is not the ultimate truth, so you can always seek advice from another specialist. If a decision is made to use Femoston, contraindications must always be taken into account. Treatment with Femoston should be stopped immediately if pregnancy occurs or there are good reasons to believe so. All the nuances of taking these hormonal pills should be discussed with your doctor.

How to take the drug correctly

Before starting to take the pills, a woman should undergo a general and gynecological examination to eliminate risks and existing contraindications. At the same time, doctors also focus on the thickness of the endometrium. If its layer is less than normal, then hormone therapy with Femoston is prescribed.

It is recommended to take the drug starting on the day of the first monthly bleeding. The tablets are taken one at a time. They start taking pink tablets, then switch to yellow ones, and after finishing them they immediately start a new blister of pink ones, without taking a break. If you make an interval in taking it, then stopping the medication will cause withdrawal syndrome in the form of bleeding, and the thickness of the endometrium will decrease again.

If the inability to get pregnant is due to insufficient luteinization, then the drug is taken one tablet for two weeks, after which Duphaston is added to the yellow pills. This scheme allows you to enhance the therapeutic effect of the hormonal drug.

What to do if you miss a pill

If a woman was unable to take the drug at the prescribed time of administration, she needs to make up for the omission as soon as possible. Moreover, you need to find time for this within 12 hours. If the delay is more than 12 hours, then the pill is taken according to the established schedule, and the forgotten one is not taken, since taking two pills can cause bleeding.

If pregnancy occurs

When signs appear that conception has occurred, the need for the drug disappears. It should be canceled and immediately visit your gynecologist to determine further actions. If after the examination it is discovered that the endometrial layer is too thin, it may be necessary to extend the course or prescribe other drugs to strengthen it. Maintaining pregnancy will depend on the accuracy of the instructions and their implementation.

Use of Femoston when planning pregnancy: special instructions

Femoston should be taken with caution, keeping in mind some of the pitfalls of treatment with hormonal drugs:

1. If a woman becomes pregnant during treatment with this medicine, the issue of discontinuing the drug and saving the child should be decided exclusively at an appointment with the attending physician.
2. Taking all varieties of Femoston can cause edema, so the drug should be prescribed with great caution to women who suffer from pathologies of the renal and cardiovascular systems.
3. Femoston 2/10 is contraindicated in patients with acute and chronic liver diseases, even in the initial stages.
4. Before starting treatment with Femoston, a woman must undergo a comprehensive examination of the genitals and mammary glands. If there are any neoplasms in the uterus, ovaries or breasts, the hormonal drug cannot be taken.
5. If during treatment with Femoston nodules and lumps appear in the breast, the woman should immediately seek help from a specialist.

Indications for use

The use of Femoston is indicated for hormone replacement therapy to eliminate phenomena caused by estrogen deficiency in postmenopausal .

The medicine is prescribed no earlier than six months after the last menstrual bleeding.

Prophylactic use of the drug is advisable to prevent the development of osteoporosis after the onset of menopause . The drug is prescribed to women who have an increased risk of fractures and who are contraindicated in the use of other medications intended to prevent bone loss.

Analogs

Level 4 ATX code matches:
Klimonorm

The generic (structural analogue) of Femoston ⅕ is the drug Femoston Conti 1/5.

Drugs with a similar mechanism of action: Divina , Klimonorm , Kliogest , Trisequence .

Klimonorm or Femoston - which is better?

The decision about which drug from the group of combined estrogen-gestagen agents should be chosen is made by the doctor based on the data received from the patient about the period of age-related hormonal changes.

It is believed that in the drug Klimonorm the progestin component is present in the most optimal concentration, which allows effective control of the cycle and provides the necessary level of protection of the endometrium from the hyperplastic effect of estrogens .

At the same time, it is possible to maintain the beneficial effects caused by the influence of estrogens on the state of the cardiovascular system and lipid metabolism . In addition, levonorgestrel Klimonorm potentiates the effect of estradiol , aimed at the treatment and prevention of osteoporosis .

Another important feature of levonorgestrel is its almost 100% bioavailability, thanks to which it is possible to maintain the stability of the drug’s effects.

Moreover, the severity of the effects remains unchanged regardless of the woman’s nutritional characteristics, the presence of diseases of the digestive tract , as well as the activity of the liver system , which plays a key role in the processes of first-pass metabolism of xenobiotics .

The bioavailability of dydrogesterone , which is part of Femoston, is 28%, and therefore its effects are subject to fluctuations (both inter- and inter-individual).

Angelique or Femoston - which is better?

Experts believe that there is not much difference between these means. The main difference between the drug Angelique and Femoston is that it contains drospirenone progestational .

BabyMother

Being a mother is the main purpose of a woman. Those representatives of the fair sex who, for some reason, cannot achieve this cherished goal on their own, are ready to seek medical help from a variety of specialists, undergo a lot of examinations, and endure unpleasant procedures. However, not everything is and is not always so tragic. There are times when it is enough for a woman to undergo a course of therapy with some special drug, and here it is – happiness. Pregnancy occurs, and the fair sex lives in anticipation of a miracle - the birth of a new person, her child.

Today, many medications have been developed that can help a woman become pregnant. One of these is Femoston 2/10. When planning a pregnancy, this medication can provide significant support to the female body and create conditions for successful fertilization of the egg.

The medication is a combined hormonal drug intended to eliminate the deficiency of the hormone estrogen in a woman’s body and to provide therapeutic therapy for dysfunctional uterine bleeding. Femoston 2/10 tablets are packaged in packs of 28 pieces; each blister contains two colors: pink and light yellow. 14 pink tablets contain estradiol in a volume of 2 mg each as an active ingredient. The remaining 14 tablets (light yellow) contain 2 mg of estradiol and 10 mg of dydrogesterone each.

The auxiliary components are lactose, hypromelase, starch (corn), magnesium stearate and colloidal silicon dioxide.

The tablets are biconvex, round, film-coated.

The drug "Femoston 2/10" (reviews, instructions confirm this information) is a good remedy for replenishing estrogen deficiency, which is often observed after menopause. This medication is also good for eliminating psycho-emotional and autonomic abnormalities that accompany the onset of menopause. These include hyperhidrosis (increased sweating), flushing of the face, increased nervous excitability, abnormal sleep patterns, headaches, dizziness, and decreased bone mass (osteoporosis).

There are other indications for using the drug "Femoston 2/10", and pregnancy in the planning stage is one of them. For its appointment certain conditions must be met:

1) an insufficient amount of estrogen by the end of the first half of the menstrual cycle (follicular phase) will make itself felt by the insufficient thickness (no more than 7-8 mm) of the endometrial layer;

2) diagnosed infertility caused by hormonal imbalance in the body.

Medical professionals using this drug are trying to solve problems that prevent a woman from becoming pregnant: a thin layer of the endometrium and a lack of estrogen. Dydrogesterone - one of the components of the drug "Femoston 2/10" - when planning pregnancy, stimulates the uterine mucosa to grow and thicken. This is important so that the fertilized egg can easily attach to the wall of the uterus.

In addition, the drug helps the woman’s body restore the regularity of the ovulation process, without which conception and pregnancy are impossible in principle. Although it must be said that ovulation should not occur while taking the pills. This process resumes after the course of therapy is completed.

Many representatives of the fair sex doubt the effectiveness of using the medication “Femoston 2/10”. Reviews and pregnancy, which occurred in a considerable number of women after finishing taking it, prove that taking this drug is very justified when planning a conception.

Not every specialist prescribes Femoston 2/10 when planning a pregnancy. The reason is a large list of contraindications. Women who have been diagnosed or suspected of having malignant neoplasms dependent on the level of estrogen and progesterone should not take it.

The drug is not prescribed to women suffering from vaginal bleeding of unknown origin, who have not cured hyperplasia (pathological growth) of the endometrium. It is inadmissible to use the medication in the presence (or history) of venous thromboembolism, angina pectoris, myocardial infarction (in the active phase or recently suffered).

It is forbidden to take the drug to patients suffering from active liver disease, or if the biochemical parameters of this organ have not yet returned to normal. A contraindication for taking the medication is the patient has porphyrin disease (a disorder of pigment metabolism due to an increased content of porphyrins in tissues and blood).

Women with individual sensitivity to estradiol and dydrogesterone, as well as other components of the Femoston 2/10 medication, should not take this drug. Reviews and instructions indicate negative consequences if you take the medicine during pregnancy. Therefore, you should stop using it even if you only assume that you are in an interesting situation. During the lactation period, the drug is also prohibited. It is not prescribed to children and adolescents under the age of 18.

Most often you can hear about the medication in a negative context due to negative manifestations in the form of headaches, discomfort in the pelvic area and abdomen, migraine attacks, nausea, and flatulence. The use of Femoston 2/10 can cause pain in the mammary glands, increase their sensitivity, provoke the appearance of bloody discharge from the vagina against the background of menopause, and significantly affect weight changes (increase or decrease).

Clinical studies have shown that quite often you can hear about side effects in the form of the development of vaginal candidiasis, an increase in the size of uterine fibroids, changes in libido, increased nervousness or depression. In addition, experts put the development of ulcerations on the cervix and the appearance of discharge from the cervical canal in direct dependence on the use of the medication “Femoston 2/10”. Reviews from doctors report that cases of peripheral edema, urticaria, skin rashes, and dysmenorrhea were recorded during the use of the product.

Quite rarely, but you can hear about such side effects as disorders in the functioning of the liver, premenstrual tension syndrome, changes (usually upward) in the curvature of the ocular cornea, rejection, and rejection of contact lenses.

Sometimes it is possible to develop such serious diseases as stroke, increased susceptibility to myocardial infarction, anemia (hemolytic nature), vascular purpura. There have been cases of increased blood pressure, development of dyspepsia, pancreatitis, systemic lupus erythematosus, and signs of dementia (rare).

Before answering the question of how to drink Femoston 2/10, it should be said that it is recommended to take the estrogenic component of the medication constantly, and the progestogen component from the middle of the menstrual cycle until the end (with a cycle of 28 days, start on the 15th day). Simply put, in the first half a woman should take one pink tablet, and from the middle of the cycle, usually from day 15, switch to taking yellow tablets.

Typically, therapy begins with a minimum dose of estradiol, which is 1 mg. Therefore, if combined long-term treatment with this drug is intended, experts prefer to first prescribe Femoston 1/10. Then, if necessary, the patient is transferred to a higher dose.

Treatment can only begin after the full four-week cycle has been completed.

If for any reason the next pill is missed, it should be taken immediately. However, if more than 12 hours have passed since the time at which the drug is usually taken, there is no longer a need to take the missed dose. It is not recommended to use a double dose of Femoston 2/10. Similar drugs are generally characterized by the same administration characteristics. If you take a double dose, you will still not be able to make up for the missed dose, but the likelihood of bleeding will increase. Also in such cases, spotting vaginal discharge may appear.

As for the use of the drug by patients over 65 years of age, it is difficult to say anything here, since there is not enough reliable information about the results of such use. There are also no indications for prescribing Femoston 2/10 (the drug is, after all, a hormonal drug) to children and adolescents.

If we talk about structural analogues (generics) of Femoston, the closest of them is Femoston 1/5 Conti. Trisequence, Divina, Kliogest, and Klimonorm have a similar principle of influence on a woman’s body. The final word on the question of what to replace Femoston 2/10 should remain with the attending physician.

Medical workers speak positively about such an analogue as “Klimonorm”. The reason is that, according to clinical studies, in this medication the progestin component is present in the optimal dosage necessary for effective control of the cycle and ensuring the proper level of protection of the endometrium from the influence of estrogen. In parallel with this, it is possible to maintain the positive effects of estrogen on the state of the cardiovascular system and lipid metabolism processes.

Also, Femoston 2/10, analogues of which make up a fairly large group, is often replaced by patients with the drug Angelique. Although experts are inclined to believe that there is no particular difference between these medications. The main difference is that the gestagenic component of Angelica is drospirenone at a dosage of 2 mg per tablet.

If it is known for certain that a woman is pregnant or there is reason to suspect such a fact, you should stop taking Femoston 2/10.

When planning pregnancy, it can be very effective for the reason that the volume of estradiol in pink tablets, recommended for use in the first half of the cycle, does not inhibit or suppress the ovulation process, simulates the correct course of the follicular phase and stimulates endometrial cells to divide and grow.

The optimal balance of the two main components for the second half of the cycle can ensure (in case of conception) the normal introduction of the fertilized egg into the inner layers of the uterus. Thus, “Femoston 2/10” (reviews from doctors once again confirm this) is a remedy for eliminating irregularities in the menstrual cycle.

Reviews from patients can be quite contradictory. Most often, the drug was used to normalize the condition after the onset of menopause and for planning pregnancy. Many people leave enthusiastic reviews about the medication “Femoston 2/10”. Pregnancy resulting from therapy makes women happy. Such patients report good tolerability of the pills, stabilization of their health, and improved well-being. The medication also has a good effect on the skin and can normalize the menstrual cycle (if it is disrupted).

The bulk of negative feedback is associated with the development of side effects. Patients talk about depression, weight gain, swelling, and joint pain. There may be a decrease in physical activity and the appearance of skin rashes. A separate group of women complains about the lack of the expected effect.

According to medical professionals, Femoston 2/10 is a drug that is highly effective in the treatment of painful conditions associated with malfunction of the ovaries and their premature depletion. The tablets are generally well tolerated by patients. Clinical studies suggest a positive effect on the blood lipid profile and the general well-being of women. There is also reason to talk about an increase in oxygen consumption and an increase in the bone-protective effect of estrogen.

However, not all gynecologists speak so highly of Femoston. According to many, the dosage of active substances in the medication is quite high, and if pregnancy occurs, the drug can negatively affect the fetus. In addition, experts believe that the medication is ineffective when planning conception: pregnancy occurs in most cases only after very long use. Doctors also note quite frequent side effects in the form of headaches, dizziness, flatulence, irritability, and nausea. In rare cases, more serious violations occur.

Of course, a large group of medical workers is inclined to the need for the earliest possible diagnosis and initiation of differentiated treatment for women whose ovarian function is impaired, which makes pregnancy impossible.

However, there is a fairly large group of gynecologists who know how to replace Femoston 2/10 if a woman wants to conceive and give birth to a child. Doctors prefer to prescribe a special medication, Duphaston, for use in the first half of the cycle, which increases the likelihood of pregnancy.

In any case, you must strictly adhere to the instructions, take into account contraindications and resolve any issues that arise with your doctor.

The success of conceiving and further bearing a child directly depends on the state of hormonal background .

To normalize it, hormone-based medications are used at the stage of pregnancy planning. One of them is Femoston , which includes artificial estradiol and dydrogesterone.

The main purpose of the drug Femoston is to normalize hormonal levels during menopause. For a woman, the onset of menopause can be one of the most critical periods. Under the influence of hormonal changes, mood swings are observed, weight gain is possible , and the likelihood of developing certain diseases increases. Taking Femoston smoothes out the symptoms that appear.

The effect of the drug is based on the content of dydrogesterone and estradiol. An auxiliary function is performed by components such as lactose, magnesium stearate and corn starch. To understand what effect Femoston has on the female body, you need to consider what happens when there is a lack of estrogen.

This phenomenon is characterized by the following features:

• increased sweating;
• development of osteoporosis;
• increased nervous excitability;
• vegetative abnormalities;
• frequent rushes of blood to the facial area;

Taking Femoston helps eliminate these symptoms. But the use of the drug is practiced not only during menopause. estrogen deficiency has been used in gynecology . This deviation interferes with the successful process of conception, gradually turning into infertility.

The presence of chronic inflammation or hormonal imbalances can lead to endometrial depletion. It plays an important role in the process of implantation of the embryo into the uterine cavity. After ovulation has occurred, the size of the endometrium should exceed 10 mm. Deviations from the norm indicate the presence of certain problems. Very often, along with insufficient growth of the endometrium, endometriosis and anovulation are observed.

IMPORTANT! Lack of ovulation is the main cause of infertility. The egg does not leave the ovary, making conception impossible.

Femoston simultaneously increases the level of:

• estrogen (the hormone of the first phase of the cycle, responsible for the growth of follicles and enlargement of the endometrium);
• progesterone (the hormone of the luteal phase, it is responsible for the formation of the corpus luteum, and subsequently for the course of pregnancy).

The drug has several types of dosage . Her choice is made depending on the age of the patient and the severity of the disease. Incorrect dosage may cause side effects . The package contains two types of tablets, distinguished by their color. It determines in which phase of the cycle they need to be taken.

CAREFULLY! It is prohibited to determine the dosage of the drug yourself. Only the attending physician can determine the need to take medication, based on the individual situation.

Femoston in a dosage of 1/5 is prescribed to women at an older age, subject to the absence of menstruation for more than a year. At first, menstrual-like bleeding may be observed, but over time it disappears.

While taking the drug, it is necessary to conduct regular examinations of the body. Particular attention should be paid to the condition of the mammary glands .

The drug, presented in a dosage of 1/10, is used after surgery to remove the reproductive organs. In this situation, Femoston must be taken until menopause.

Otherwise, negative reactions of the body to significant hormonal changes . This affects your overall well-being.

Dosage 2/10 is used during pregnancy planning. In this case, the concentration of hormones is much lower, which allows women of reproductive age to take it. You need to take the medicine one tablet every day, preferably at the same time.

Often, taking the drug is combined with the use of other progesterone-containing medications. These include Duphaston and Utrozhestan.

Under the influence of Femoston at a dosage of 2/10, the follicles increase in size in accordance with the required standards. At the same time, the endometrium grows.

Femoston does not interfere with the ovulation process. In the second phase of the cycle, progesterone support is mandatory. Without it, pregnancy may fail at the initial stage.

ATTENTION! If pregnancy begins to develop while taking the drug, it must be stopped. However, progesterone support cannot be canceled.

Statistics show that not all women can easily tolerate taking Femoston . Often there is a deterioration in health , dizziness and fatigue. To avoid unpleasant reactions, contraindications of the drug should be taken into account. These include the following:

• Presence of intermenstrual bleeding;
• Thromboembolism;
• Kidney and liver diseases;
• Breast cancer;
• Endometrial hyperplasia;
• Individual intolerance to components;

ADVICE! You should not start taking Femoston without first taking hormone tests. If there is an excess of them, pills can harm a woman’s reproductive health.

In most cases, experts recommend planning a pregnancy after stopping the drug . It is believed that it may influence the child's future development.

After discontinuation of Femoston, the body retains a supply of necessary hormones. Gradually they begin to develop independently.

It is noteworthy that during the period of taking the pills, a woman is more focused on getting pregnant. After stopping the drug, she lets go of the situation, thereby restoring her psychological state . And your inner attitude is very important at the pregnancy planning stage.

Femoston reviews : Most women note significant side effects when taking the drug. At first, the body goes through an adaptation period . At this time, nausea, slight weakness, abdominal pain, flatulence, and dizziness may appear.

But over time, all symptoms disappear. Some women experience no discomfort at all. The effectiveness of the drug is quite high. It leads to the desired pregnancy, provided there are no more serious problems.

Before starting to take hormone-containing medications, it is recommended to consult several specialists. In some cases, the number of side effects may exceed the benefits of the drug.

In my posts, I have already mentioned in passing about such a drug as femoston. And finally, I decided to write a post: “Femoston 2/10 reviews when planning pregnancy,” since it was to him that I owe the appearance of my beloved son. He was already ten months old, and I suddenly remembered how many tears were shed, how I lost faith in myself and thought that I might never be destined to become a mother. And now my son is here with me and I understand that it’s right, I didn’t give up, and no matter what, I believed in my pregnancy. I tried to take every chance. And femoston was one of the last. Here I will leave my review and talk about whether pregnancy is possible after femoston, and how to take femoston when planning a pregnancy.

Did femoston help me when planning a pregnancy? I tried to get pregnant for a long time, took various hormones, but they did not help me. I wrote about this in detail here. Read, perhaps they will help you, because each case is individual. I was observed in a private clinic, and my gynecologist suggested a course of taking femoston as the last option, then laparoscopy was in progress. It is worth noting that I was diagnosed with insufficiency of the luteal phase of the cycle, there was low progesterone and follicle-stimulating hormone, in Russian to say that there was no ovulation at all. My pregnancy was impossible.

Is it possible to get pregnant with Femoston 2? What is this drug? This is estrogen, i.e. female sex hormones. It is usually used as hormone replacement therapy during menopause. Treatment of infertility with Femoston is the know-how of our doctors. My gynecologist assured me that some of her patients became pregnant after Femoston.

Before taking this drug, I did an ultrasound of the mammary glands, since if there are any malignant formations, they may begin to progress. I had benign lumps. As a result, I started taking Femoston 1/10. Initially, the doctor prescribed it to me. I had to take the course for three months, then get tested for hormones.

To be honest, I don’t remember the dosage of the drug or the dosage regimen, so I won’t lie to you. After three months, hormone tests showed minor changes and I was switched to Femoston 2/10. I took it for six months. There were improvements on it. And the doctor told me that I had to try, because I simply had no other choice. When planning a pregnancy, Femoston can help me conceive a baby.

On December 31st I took my last pill. And my husband and I started trying. It was the end of February and I had neither menstruated nor was pregnant. My two eternal problems. I was observed on an ultrasound machine for a month, there was no ovulation. They began to prepare me for laparoscopy. They told me to come when I was mentally ready. But I was depressed. Women who have been trying to get pregnant for a long time will understand me.

You know that feeling when you take hormones for six months and wait, wait, wait for time to pass. You think, this is the last year, and then I will become a mother. Imagine how you will walk while pregnant. You come to the appointment, and the doctor says that there is no result. Prescribes new drugs, and everything starts all over again. You're waiting again. And so it goes year after year. You look at your mother friends, at the kids in a stroller in the park, and sometimes such despair comes over you. You ask why me, why do alcoholics give birth, but I can’t. And again, examinations, hormones, but still no baby. At some point you just give up. I had just such a moment.

Now the most important thing is Femoston and pregnancy. I was depressed for about a month, but then I realized that I should never give up and decided to have a laparoscopy. I decided that nothing could be done if pregnancy did not occur on femoston 2/10. It was already the end of March. I caught a cold and had a high fever, sore throat and cough. I swallowed tons of antibiotics.

And around the beginning of April I had a miscarriage. Yes, yes, it was exactly him!!! I trusted the doctors so much that I couldn’t even imagine that I could get pregnant. Most likely, conception occurred in March. On April 3, the pregnancy was terminated. To find out for sure whether it was a miscarriage, it is enough to take a pregnancy test; it will show two stripes for another two weeks until the hormonal levels are restored. I had two stripes, so long-awaited. No cleaning was required, everything came out on its own . I won’t write about the miscarriage. Read more about what are the signs of early miscarriage, how it happened and why in this post. Pregnancy occurred on femoston 2/10. It’s just that, as I realized then, I ovulated very late, on about the 50th day of the cycle.

I cried a little in the doctor’s office, but she said that I could plan a pregnancy right now, while the femoston was still working. I calmed down and was even happy. A feeling of joy just washed over me. I realized that I was able to get pregnant on my own without IVF; if it worked once, it means there will be another. Stopping thinking about the bad, I tried to focus only on the positive aspects. That's how optimistic I am!

As a result, I took pregnancy tests throughout the month of May so as not to miss it. I was absolutely sure that they were about to show two stripes. I ruined a bunch of tests and then on May 23rd I saw them. My happiness knew no bounds. I ran to the doctor and took a test for the pregnancy hormone hCG. I was pregnant!!! I became pregnant after femoston. Then I took it dynamically for another two weeks. HCG levels increased and the pregnancy progressed. I started to feel a strong tug in my stomach, I was scared that it might be ectopic, I did an ultrasound, everything turned out to be normal, I was prescribed Duphaston and sent to register at the antenatal clinic. When is the best time to do this, read this article.

This is the story of my pregnancy. Then the doctors scolded me for getting pregnant so recklessly, immediately after a miscarriage, but I didn’t listen to them, I was just happy. You can find out more about how my pregnancy went on Femoston 2/10 and whether there were any difficulties in this article. I hope my post: “Femoston 2/10 reviews when planning pregnancy” will be useful to you.

The main thing is what I would like to wish to all future mothers, and I have no doubt at all that you will definitely become a mother, it simply cannot be otherwise, do not give up, do not despair, try to see the positive in all life situations. After all, there are no defeated people, there are surrendered people. It was not me who said this, but Leonardo Da Vinci. Good luck!!

Femoston as a source of sex hormones

Women's reproductive health depends on many factors, among which the most important are the sex hormones estrogen and progesterone. The interaction of these hormones regulates menstrual cycles throughout a woman’s fertile age; the balance of estrogen and progesterone determines the likelihood of pregnancy.

The drug Femoston contains a complex of plant estrogens and progesterone, similar in composition to human hormones. The drug contains estrogen estradiol and progestogen dihydrogesterone.

The drug is used in hormone replacement therapy for women during menopause, but is also used in young women to normalize hormonal levels when planning to conceive a child.

When planning pregnancy, the drug Femoston is prescribed to treat infertility caused by endometrial immaturity. Taking the drug causes an increase in mucus secretion in the uterus and thickening of the endometrium to a level that ensures the implantation of the fertilized egg into the wall.

The use of Femoston continues for several months. Pregnancy, as a rule, does not occur while taking the drug. Pregnancy usually occurs in response to cessation of treatment, when the drug is discontinued.

If conception occurs during treatment, stop taking the hormone replacement drug.

Interaction

Drug interaction studies with Femoston have not been conducted.

However, it is known that some drugs may affect the effectiveness of estrogens and progesterones .

Thus, anticonvulsants (for example, phenytoin or phenobarbital ) and antimicrobial (including nevirapine , rifampicin or efavirenz enzymes of the cytochrome P450 system involved in drug metabolism .

Ritonavir and nelvinavir , which are potent inhibitors of CYP 3A4, A5 and A7 isoenzymes, in combination with steroid hormones , promote the activation of these cytochromes.

Herbal remedies based on St. John's wort (Hypericum perforatum) can stimulate the biotransformation of estrogens and progestogens due to the ability to influence the CYP 3A4 isoenzyme.

There is evidence that the more active metabolism of estrogens and progestogens provokes a decrease in the clinical effectiveness of these substances and affects the profile of uterine bleeding.

In turn, estrogens can disrupt the process of biotransformation of other substances due to competitive suppression of cytochromes of the P450 system , which take part in the processes of biotransformation of active drug substances.

This should be remembered when prescribing estrogens in combination with drugs that have a narrow therapeutic index, including fentanyl , tacrolimus , theophylline , cyclosporine .

Such combinations can cause an increase in the plasma concentration of these substances to a toxic level. Therefore, there may be a need for careful monitoring of the drug over an extended period of time, as well as a reduction in the dose of cyclosporine, tacrolimus, theophylline and fentanyl .

Femoston price

Price Femoston 1/5 in Russian pharmacies from 870 rubles. You can buy Femoston Conti 1/5 for an average of 900 rubles. Price Femoston 2/10 - from 790, Femoston 1/10 - from 795 rubles.

In Ukraine, the price of Femoston 1/10 is from 438 UAH, the price of Femoston 2/10 is from 520 UAH. The cost of the drug with a dosage of 1 mg + 5 mg is from 445 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

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