With pathological processes in the liver that disrupt its functioning, the human body begins to experience malfunctions in other important organs. After all, it participates in the elimination of toxic substances and reduces their negative impact on the body.
Abnormal liver function can lead to general intoxication of the body, deterioration of health and other even more serious diseases. That is why, when you notice the first symptoms of organ diseases, you should immediately consult a doctor who will prescribe the necessary therapy.
Drugs that have proven their effectiveness and occupy leading positions in prescription for the treatment of liver diseases are Heptral and Phosphogliv.
Description of Phosphogliv
Phosphogliv is widely used for various diseases of the hepatobiliary system. The product has antiviral, hepatoprotective and membrane-stabilizing effects. Available in capsules. Manufacturer: Pharmstandard-UfaVITA. Contains phosphatidylcholine and glycyrate.
Efficiency
Phosphogliv in some studies shows high clinical effectiveness in the treatment of acute and chronic hepatitis. The combination of phosphatidylcholine and glycyrrhizic acid makes it possible to obtain a combined drug with pronounced antiviral activity.
Phosphogliv significantly improves liver function and reduces symptoms of organ failure. This drug shows better results than basic therapy. Important advantages of Phosphogliv include its good tolerability; cases of allergies are rare. The drug can be recommended for the treatment of diffuse and viral liver diseases of acute and chronic course.
Source: “The use of Phosphogliv for acute and chronic viral hepatitis in children.” Uchaikin V.F. 2006.
Contraindications
You should not take Phosphogliv if you are intolerant to the components in the composition. The drug is also contraindicated for pregnant and lactating women. There are restrictions up to 12 years. Other contraindications include antiphospholipid syndrome, severe hypertension, and portal hypertension.
Side effects
When using Phosphogliv, you need to take into account the risk of adverse reactions such as:
- dyspeptic symptoms;
- increased blood pressure;
- nasal congestion, cough, inflammation of the conjunctiva;
- rashes;
- swelling.
If the listed symptoms and other unpleasant manifestations appear during treatment with Phosphogliv, you should consult your doctor.
Dosage
You need to drink during meals, without chewing the capsule. Adults are recommended to take 2 pieces 3 times a day. The course of treatment lasts about 3 months. Phosphogliv is not prescribed for children under 12 years of age.
Who is it suitable for?
The hepatoprotective drug Phosphogliv is prescribed for:
- hepatosis or fatty degeneration;
- alcoholic liver damage;
- in the treatment of psoriasis, hepatitis, cirrhosis.
The drug should not be used as monotherapy for liver diseases. It is worth considering that the effectiveness of hepatoprotectors, except those containing ursodeoxycholic acid, has not been proven.
Comparison of Heptral and Phosphogliv
For comparison, it is necessary to highlight the similarities and differences of the drugs.
Similarities
Medicines are included in the group of hepatoprotective medicines. They are aimed at protecting the liver from negative effects. Both drugs improve the body's defenses and accelerate the recovery of cells in the liver, improving the functioning of the organ. In addition, the drugs have the same release forms.
What is the difference?
The drug Heptral is produced in Italy, and Phosphogliv - in the Russian Federation. The peculiarity of the Italian pharmaceutical product is that it has detoxifying, choleretic, neuroprotective and antidepressant properties. Phosphogliv has anti-inflammatory, antiviral and immunostimulating effects.
Medicines also differ in composition. The Italian product contains ademetionine, and the Russian one contains glycyrate and phosphatidylcholine. In addition, Heptral more often causes negative reactions during the course of its use.
A solution made from Heptral lyophilisate is suitable for both intramuscular and intravenous administration. A liquid is made from Russian powder, which is administered only intravenously.
What is more effective?
The Italian-made medication has a more pronounced pharmacological activity, so its use should be started only if there are significant indications and under the close supervision of a doctor.
Phosphogliv has a milder effect, so it is approved for use in patients over 12 years of age.
Which is cheaper?
The price of Phosphogliv in capsule form is about 530 rubles. for a package of 50 pcs, bottles with lyophilisate cost about 1,500 rubles for 5 pcs.
Italian medicine is more expensive. So, 20 Heptral tablets cost about 2,000 rubles. The medicine in powder form for the preparation of an injection solution is sold at a price of 1,650 rubles.
Description of the product Ursosan
Ursosan is a hepatoprotector based on ursodeoxycholic acid (UDCA). Produced in capsules by PRO.MED.CS Praha. One of the few hepatoprotective drugs that have proven effectiveness in the treatment of liver pathologies. It has an immunomodulatory, hypolipidemic, choleretic effect.
UDCH is embedded in the membrane, protecting it from damaging factors and stabilizing the structure. Helps dissolve gallstones and prevent the appearance of new ones.
Efficiency
Ursosan is the drug of choice for diseases of the liver and biliary tract. It affects different parts of the pathogenetic process of the disease. Ursosan is widely used to prevent the formation of cholesterol stones in the gallbladder.
UDCA is used as a symptomatic drug in combination with other drugs, which can significantly improve the prognosis. In recent years, Ursosan has shown itself well in the treatment of functional gastrointestinal pathologies.
Experimental studies have proven the effectiveness of Ursosan for reflux esophagitis, chronic pathologies of the liver and gallbladder, and some gastrointestinal diseases. The clinical effect of use for various disorders is observed within 2-3 weeks. The result lasts 6 months or more depending on the disease.
Source: “Possibilities of using Ursosan in gastroenterology.” Minushkin O.N. 2009.
Contraindications
Hepatoprotector Ursosan is contraindicated for use when:
- intolerance to components;
- decompensated cirrhosis;
- non-functioning gallbladder;
- severe disruption of the pancreas, liver and kidneys.
UDCA can be used at any age, but Ursosan is not recommended for children under 3 years of age. The drug can be prescribed to pregnant women when the benefits outweigh the risks.
Side effects
The medicine is well tolerated. Rare side symptoms include diarrhea, vomiting, and allergic manifestations.
Dosage
For stones – 10-15 mg/kg per day. Duration of treatment is 6-12 months or more. The entire dose is taken at one time before bedtime.
After cholecystectomy - 500 mg/day, hepatitis - 10-15 mg/kg in 3 doses throughout the year, cholestasis - 12-15 mg/kg from six months, dyskinesia - 10 mg/kg/day up to 8 weeks, reflux and esophagitis - 250 mg/day at bedtime up to 2 years.
Who is it suitable for?
Ursosan helps with:
- non-alcoholic fatty disease;
- dyskinesia;
- cholestasis;
- toxic and medicinal hepatitis;
- gallstone disease.
Heptral
Heptral is a hepatoprotective agent characterized by a strong antidepressant effect. The drug is involved in important biochemical reactions of the body and metabolism. It has choleretic, neuroprotective, antioxidant and antifibrosing effects.
The active ingredient is ademetionine , a derivative of the essential amino acid methionine. It normalizes the production of the coenzyme of the same name in the body, in particular in the liver and brain.
The medicine is recommended for use in the following cases:
- Intrahepatic cholestasis in women during gestation.
- Pathological processes in the liver - hepatitis, toxic lesions, etc.
- Symptoms of depression.
Heptral is a serious drug, the use of which can cause a number of undesirable reactions from the body: dyspeptic disorders, allergic manifestations, chills, fever, swelling, muscle spasms, etc.
You should stop taking the drug if you have at least one of the following symptoms:
- Children under 18 years of age.
- Individual intolerance to components.
- Insufficiency of cystathionine-b-synthase, disturbance of cyanocobalamin metabolism in the body.
The medication is available in 2 forms: tablets or lyophysilate for the preparation of a solution for intravenous or intramuscular administration.
Cost and analogues
| Medicine | Price | Analogues/substitutes |
| Phosphogliv | No. 50 – from 450 rubles | Rezalut Essentiale Forte N Essliver Forte |
| Ursosan | No. 50 – 770 rubles | Ursofalk Ursodez exhol Urdoxa Ursoliv |
Which is better Phosphogliv or Ursosan
Medicines belong to hepatoprotectors, but the indications and mechanism of action of the medicines are different. Phosphogliv is used to treat liver hepatosis and viral diseases that affect an important internal organ. Ursosan has another effect - it prevents stagnation of bile.
The drug Phosphogliv is effective for the treatment of hepatitis of various etiologies.
The drug is prescribed individually depending on the diagnosis. Ursosan treats chronic hepatitis B and C, prevents the destruction of liver cells and normalizes laboratory parameters.
The drug Phosphogliv is effective for the treatment of hepatitis of various etiologies. The medicine contains esters of polyhydric alcohols and fatty acids, provides their hepatoprotective effect and affects the magnitude of the viral load of glycyrrhizinate.
For fatty hepatosis
Liver steatosis is treated with the hepatoprotector Phosphogliv, which is recommended for the patient to take 2 capsules orally 3 times a day along with meals for 3 months. In case of fatty hepatosis, Ursosan reduces the amount of fatty acids in the blood serum, the drug affects the mechanism of development of liver steatosis.
Which drug is better
Phosphogliv is a combination drug that is used for viral hepatitis. This drug, according to the manufacturer, has immunomodulatory and antioxidant effects. The active substance in the composition protects the liver from viruses and restores membranes.
Ursosan is a single drug containing only ursodeoxycholic acid, but this is already enough to protect the liver from degenerative changes and prevent the formation of stones in the biliary tract. The drug improves gall motility, helps eliminate old bile, toxins and cholesterol.
The action of Phosphogliv is aimed at eliminating hepatosis, Ursosan - at dissolving stones, stimulating the motor function of the gallbladder, treating cholelithiasis and cholecystitis.
Ursosan is superior to Phosphogliv in many ways, but the drugs have different indications, so they can be compared when considering a specific disease. To choose the most effective remedy, you need to consult a doctor. Self-medication can be dangerous.
Reviews from doctors about Heptral and Phosphogliv
Alena (hepatologist), 38 years old, Samara
I often prescribe hepatoprotective medications to my patients. These medications improve the condition of the liver and minimize stress on the organ. Both Heptral and Phosphogliv are extremely effective agents. They rarely cause adverse reactions if you adhere to the dosage regimen and dosage regimen recommended by a medical specialist.
Igor (hepatologist), 44 years old, Volgodonsk
These medications have pronounced medicinal activity, so they should not be used without consulting a doctor. The specialist will conduct an examination and help promptly identify possible contraindications to such treatment.
Is it possible to take Heptral and Ursosan at the same time?
The combination of pharmacological drugs is not prohibited, since the drugs have different “targets” of action. However, in clinical practice, Ursosan and Heptral are rarely prescribed. The preference for therapy with only one drug is due to several reasons:
- The positive and negative effects of simultaneous use of Heptral and Ursosan have not been sufficiently studied. There have been no studies in the world with a high level of reliability that would prove the advantages of the combination over one of the drugs;
- High cost - the price of one course of Heptral is from 3000 rubles. up to 5000 rub. The cost of Ursosan is somewhat lower, but such treatment remains quite expensive for the patient.
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Phosphogliv or Ursosan: which is better?
It is impossible to unequivocally answer which is better, Ursosan or Phosphogliv. Since these drugs, although they belong to the same group of drugs - hepatoprotectors, have different active ingredients in their composition. In this regard, the indications for prescribing medications, as well as the mechanism of action, are different. Phosphogliv has proven itself in the treatment of fatty degeneration (degeneration) of liver tissue (hepatosis), due to excessive accumulation of lipids. This drug is also prescribed for the treatment of viral liver damage.
Ursosan, in turn, is advisable to prescribe for the treatment of bile stagnation in the liver, as well as the prevention of the formation of cholelithiasis. This drug is effective for cirrhosis, with the proliferation of connective tissue.
Patients' opinions
Alla, 40 years old, Arkhangelsk: “The gallbladder was removed. Due to an incorrect diet, the liver became enlarged and obesity developed. The doctor prescribed Phosphogliv. An ultrasound revealed a slight improvement. She was in the hospital, the drug was administered intravenously. The doctor recommended long-term treatment with a hepatoprotector.”
Galina, 72 years old, Novomoskovsk: “The doctor recommended taking the medication Phosphogliv. After 7 days, tests showed a decrease in liver size by 2 cm. The medicine eliminated the tingling and burning sensation in the right hypochondrium after eating. The treatment gave a positive result.”
Irina, 81 years old, Stavropol: “I was admitted to the hospital with pain in my right side and bitterness in my mouth. The doctor prescribed the drug Ursosan, which must be taken for 6 months. After treatment, the gallstones in the picture did not disappear, but became smaller in size. I took a capsule of the drug in the evening before bed.”
What is the difference between Ursosan and Heptral?
- Effects of drugs:
- Heptral does not reduce the concentration of cholesterol in the blood, does not affect the process of stone formation in the biliary system, and also does not affect the patient’s immunity. However, Ursosan does not have an antidepressant effect.
- Indications:
- Heptral can be prescribed against the background of depression or withdrawal symptoms;
- Ursosan is used for cholelithiasis and to prevent liver damage;
- General indications for 2 medications: stagnation of bile and disruption of the ducts of the biliary system, inflammation of the liver, cirrhosis.
- Use during pregnancy:
- Ursosan is a first-line drug for pregnant women with signs of bile stagnation;
- Heptral is allowed only after the 30th week of pregnancy.
- Price:
- Ursosan is 2 times cheaper.
Can I take it together?
Hepatoprotectors can be taken at the same time if the doctor approves the combination of drugs. When medications are used together, the amount of cytochrome P-450 increases. The compatibility of hepatoprotectors allows you to quickly obtain the effect of treating liver diseases.
Medicines are taken together for the treatment of hepatitis C, but long-term use of Ursosan is undesirable. The use of Phosphogliv causes an increase in blood pressure in patients with hypertension. The doctor recommends taking the medication for 30 days, followed by switching to treatment with Ursosan for 60 days.
How to use
Medicine Phosphogliv should be taken orally, without breaking the capsule shell, after meals, with 0.25 cups of boiled water. The doctor prescribes 2 capsules 3 times a day. The medication is used for 3-6 months.
The drug Ursosan is taken with meals to eliminate gallstones at a dose of 10 mg/kg. The capsule is taken before bedtime with a small amount of liquid. Treatment lasts 1 year.
To prevent the recurrence of gallbladder pathology, take 250 mg of the medication 2 times a day for 1-3 months. Treatment of hepatitis of viral etiology is accompanied by taking a hepatoprotector at a dose of 10-15 mg/kg 2-3 times a day.
The duration of therapy is determined by the doctor. Biliary cirrhosis, cholangitis, fibrosis are treated with medication at a dose of 12-15 mg/kg. The patient takes the medicine 2-3 times a day. The course of therapy is 6 months.
If the patient is concerned about obstruction of the biliary tract, he takes 10 mg/kg of the medication 2 times a day for 2 months. Biliary reflux gastritis is treated with Ursosan, which is used in a daily dose of 1 capsule 1 time at night. The duration of therapy is six months, the maximum period of treatment is 2 years.
