Prajisan: instructions for use, reviews during pregnancy

Utrozhestan during pregnancy

Modern gynecologists are very fond of prescribing this drug or its analogues. Poor ecology and a frantic pace of life weaken us, and even the most seemingly healthy women have situations when they need to support the body hormonally. Progesterone drugs help a pregnant woman spend months waiting for her baby without unnecessary risks .

Release form, composition, mechanism of action

Utrozhestan is available in the form of capsules; depending on the dosage, they can be round (100 mg) or oval (200 mg). The capsules are soft to the touch, because... They have a gelatinous shell, and inside them there is a liquid substance. They can be either drunk or inserted into the vagina using the principle of suppositories. The active ingredient is progesterone . Usually a hormone of plant origin is used, a complete analogue of the female sex hormone. Once in the blood, it binds to receptors on the surface of the “target” organs (uterus and ovaries) and penetrates the nuclei of their cells. It helps the uterus reach the state necessary for the proper development of a fertilized egg. It becomes soft and does not shrink, which allows the egg to attach firmly and receive nutrition. In addition, progesterone suppresses ovulation, promotes the development of mammary glands, and helps the expectant mother accumulate fat (yes, this is also intended by nature for the safe bearing of a baby).

At the pregnancy planning stage, Utrozhestan helps to form a thick mucous membrane (endometrium) on the uterus, which will allow the egg, if fertilized, to attach to the uterus and begin development.

Use in early and late pregnancy

The official instructions for the drug state that pregnant women need to take Utrozhestan in the first and second trimesters of pregnancy. This is due to the fact that progesterone deficiency can only occur when the placenta is not fully formed. At 16–20 weeks, the placenta is fully formed and provides the baby with hormones. Taking progesterone drugs after 20 weeks is considered pointless by many. However, each case is individual, and there are women for whom doctors extend the drug to 34–35 weeks, mainly due to increased uterine tone.

The only question here is trust in the doctor. At one time I had to put Utrozhestan before 27 weeks. I believe that I would have used it until the very end if I had not raised the question of stopping taking it. The pregnancy proceeded calmly, and it seemed that there was no point in spending money on an expensive drug, which, moreover, had to be taken regularly, without missing a single capsule (this meant regular trips to the pharmacy and an endless search for discounts).

Objectively: there are other drugs, with a different mechanism of action, aimed at maintaining pregnancy in the third trimester, for example, Ginipral. It prevents excessive tone. However, the issue of stopping taking Utrozhestan or switching to other medications should be discussed only with your doctor! Utrozhestan does not have any effect on the fetus, so there is no need to be afraid to take it if the doctor insists on it and gives valuable arguments.

Analogues of the drug

"Prajisan", the instructions for use of which were discussed above, is not the only drug of its kind. If necessary, it can be replaced with other medications with a similar type of action. These include:

"Endometrin" (vaginal tablets).
"Utrozhestan" (capsules).
"Prolutex" (injection solution).
"Progestogel" (gel).
"Progestin-Kr" (gel).
"Proginorm" (capsules).
"Progesterone" (solution for injection).
"Lutein" (vaginal tablets, sublingual tablets).
"Crinol" (vaginal gel in an applicator).
"Krinon" (gel).
"Iprozhin" (capsules).
"Ingesta" (injection solution in ampoules).
"Guna-Progesterone" (drops for oral use).
"Ginprogest" (capsules).
"Vanel" (capsules).

All of them contain progesterone as an active component and excipients.

It is prohibited to replace the drug with analogues without consulting your doctor!

Indications, contraindications, side effects

Pregnant women are prescribed Utrozhestan for:

threat of abortion or if the woman has had abortions before;
the existing threat of premature birth (when the due date has not yet approached, and the cervix has begun to shorten);
increased uterine tone.

My doctor prescribed this drug to me after an ultrasound at 7–8 weeks of pregnancy. The reason was the discovery of a corpus luteum cyst (as a result, a possible disruption in the production of progesterone). In addition, the gynecologist drew attention to the insufficient attachment of the fertilized egg to the walls of the uterus. The doctor immediately predicted that I would have to drink Utrozhestan until the middle of the second trimester. In addition to taking hormones, motor rest was prescribed at least until the first screening.

To survive, the embryo must literally “grow” into the endometrium, and this requires progesterone

Women planning pregnancy and those diagnosed with infertility are prescribed Utrozhestan in preparation for the IVF procedure:

to support the luteal phase (this helps the egg, if fertilized, to gain a foothold in the uterus);
as hormone replacement therapy if the body does not produce enough progesterone.

In addition, Utrozhestan softens the onset of menopause and improves the quality of life of women who have had their ovaries removed for some reason.

Contraindications to the use of Utrozhestan are:

thrombosis and thromboembolic disorders;
bleeding from the vagina with an unknown cause;
presence or suspicion of malignant tumors of the breast or genital organs;
porphyria;
incomplete abortion;
liver diseases;
age under 18 years (studies not conducted);
breastfeeding (passes into breast milk);
allergic reactions to the components of the drug (especially soy lecithin).

The manufacturer recommends using the drug with extreme caution in women with diabetes, cardiovascular disease, photosensitivity, asthma, and kidney disease.

Like any hormonal drug, Utrozhestan has side effects. If the “side effects” make themselves felt too strongly, then you should talk to your doctor about reducing the dosage.

Women taking this drug may experience:

drowsiness, dizziness;
menstrual irregularities, spotting outside of menstruation;
headache;
nausea, bloating, constipation or diarrhea;
skin rashes, itching.

If the side effects are too severe, your doctor may recommend switching from oral to intravaginal: as mentioned above, the capsules can be used in both ways.

Prajeesan

Pharmacological action of Prajisan

Progesterone (the active component of Prajisan) is a hormone of the corpus luteum that causes the transition of the uterine mucosa from the proliferation phase to the secretory phase.

When Prajisan is used vaginally, progesterone binds to the vaginal mucosa and is continuously released for at least three days.

Release form

Homogeneous white vaginal gel, 1 g of which contains 80 mg of active substance (progesterone). In vaginal plastic applicators, 1.35 g for single use;

Light yellow oval capsules with a white oily suspension. Each capsule contains progesterone in amounts of 100 mg and 200 mg. 10 capsules in a blister.

Analogues of Prajisan

Analogues of Prajisan in terms of the active component include Progesterone, Iprozhin, Krinon, Utrozhestan, and in terms of the mechanism of action - Medroxyprogesterone-LENS and Oxyprogesterone capronate.

Indications for use of Prajisan

In addition, Prajisan is effective for maintaining the luteal phase during the use of additional methods of reproduction and as hormone replacement therapy in postmenopause along with estrogen medications.

Contraindications

Acute thrombosis or thrombophlebitis, as well as thromboembolic diseases and acute cerebrovascular accidents;

In addition, Prajisan capsules should not be taken against the background of severe liver diseases, including hepatocellular carcinoma, hepatitis, cholestatic jaundice. This warning applies to both current illness and history in cases where liver function tests have not returned to normal values.

Use of Prajisan during pregnancy and lactation

the test will show pregnancy after a week Yes, but only if the woman uses a modern pregnancy test, the sensitivity of which is 10 IU/l. To determine the sensitivity of a particular pregnancy test, care must be taken

The use of Prajisan during pregnancy is not contraindicated, however, the instructions indicate the existing risk

Source

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Features of the use of hormonal drugs

If the doctor has prescribed you to take the drug once a day, then it is best to drink/put the capsule at night, because it can cause drowsiness. When taken orally, the capsule must be swallowed with plain water. When inserting into the vagina, you must wash your hands and insert the capsule as deeply as possible.

You should not take Utrozhestan with food: food will hinder the absorption of progesterone!

Only a doctor prescribes the dosage and regimen of the drug! Taking the drug in pregnant women and those who are just dreaming of conceiving a baby will differ greatly in the number of capsules per day and the duration of treatment. The manufacturer of the drug recommends taking 100–200 mg of the drug at a time and not going beyond the daily norm of 600 mg.

Depending on the goals and condition of the woman, the doctor may prescribe a regimen of 2 or 3 doses per day. It is not necessary that the doses in the morning and evening will be equal: 200 mg at night and 100 mg in the morning are often prescribed to avoid weakness. The dose can also be maintenance, only 100 mg - it all depends on the diagnostic results. Therefore, first of all, you should focus on the doctor’s recommendations, because The annotation describes only the general principles of treatment. The duration of the course will also be determined by the gynecologist. The official instructions prescribe the use of the drug until the end of the second trimester . For those planning a pregnancy, the course of treatment is usually shorter: it lasts 10 days, starting from the 17th day of the cycle.

Like any other hormonal drug, Utrozhestan must be taken strictly according to the schedule and preferably at the same time. It must be discontinued gradually: over the course of a week, the dosage is reduced by half (that is, the amount of the substance is reduced), then the same amount is taken once a day, then every other day, and then reduced to nothing. The doctor should also describe the withdrawal plan.

A pill box or a special application on your phone will help you not to miss taking a capsule.

It is not advisable to skip taking pills. In my practice, there was a case when the pack ran out and a new one had not yet been purchased, and I had to skip the evening reception. There were no consequences from this, although unnecessary nerves were wasted. There are situations when the drug disappears from pharmacies due to supply interruptions. Considering all this, it makes sense to purchase Utrozhestan with a reserve: anyway, the drug is not abruptly canceled, which means it will most likely be used up.

The progesterone drug actively interacts with other medications. If a woman has to take other pills, she should definitely consult a doctor.

Photo gallery: which drugs cannot be combined with Utrozhestan

Overdose

If the required doses of the drug are exceeded, patients may experience:

shortening of the menstrual cycle;
dysmenorrhea;
state of euphoria;
transient dizziness;
drowsiness.

The method of getting rid of overdose symptoms depends on their type. For example, in case of irregularities in the menstrual cycle or spotting, the use of the drug is postponed to several days later.

If you feel drowsy or dizzy, your doctor may recommend taking the drug before bed or reducing its dosage.

If necessary, symptomatic therapy can be performed.

"Utrozhestan" during pregnancy: instructions for use

Some expectant mothers face hormonal changes, which result in the threat of miscarriage or even termination of pregnancy. In many cases, they are caused by a lack of progesterone, a substance that ensures normal pregnancy. This hormone must be produced by the corpus luteum throughout the first trimester, and from the 16th obstetric week its production becomes one of the functions of the placenta.

If for some reason the female body is unable to synthesize progesterone, doctors prescribe its substitutes, for example, Utrozhestan. The main objective of using this drug is to replenish natural progesterone. It is thanks to this that the prescribed course helps to maintain pregnancy.

Characteristics of the drug

The only dosage form of Utrozhestan is capsules. This medication is not available in the form of gel, tablets or solutions. The main ingredient of the drug is micronized progesterone. Its dosage in each capsule is 100 or 200 mg. The amount of active ingredient affects both the shape of the capsules and the packaging.

The drug with a dosage of 100 mg has a round shape and is sold in 28 pieces per pack (14 capsules in one blister). The drug shell is made of glycerol and gelatin with the addition of titanium dioxide. It is shiny and yellowish, and inside there is a homogeneous white oily liquid, which, in addition to progesterone, includes soy lecithin and sunflower oil.
The drug with a dosage of 200 mg has the same composition and is also presented in pale yellow soft gelatin capsules, inside of which a whitish suspension is placed. The difference between this medicine is the shape of the capsules - they are oval. In addition, the drug is packaged in 7 capsules in one blister and sold in 14 pieces in one cardboard box.

The medication is a prescription drug, therefore it is sold in pharmacies only after presentation of a prescription, which excludes the use of the hormone for other purposes. The average price of one package, regardless of dosage, is 400 rubles. Utrozhestan should be stored at home during the entire shelf life (3 years from the date of manufacture) in a place hidden from small children. The manufacturer's recommended storage temperature is up to +25 degrees Celsius.

Prajeesan

Prajisan is a hormonal drug based on progesterone. This drug reduces the excitability and contractility of the uterine muscles, promotes the development of normal endometrium, and also increases the production of aldosterone. The main indications for the use of Prajisan are: infertility (provoked by luteal insufficiency), dysfunctional uterine bleeding and secondary amenorrhea.

Release form

oval capsules of light yellow color, inside of which there is a white oily suspension. One capsule contains 100 or 200 milligrams of progesterone. They sell capsules in blisters (10 pieces each);

white vaginal gel. One gram of gel contains 80 milligrams of progesterone. The gel is sold in vaginal plastic applicators (disposable) of 1.35 grams.

How does it work?

Since the main component of Utrozhestan is completely identical to natural progesterone, the capsules can replace the natural hormone produced by the corpus luteum. This substance is needed in order to:

prepare the uterine mucosa to receive the fertilized egg;
reduce the excitability and activity of the muscular lining of the uterus and fallopian tubes, thereby preventing egg rejection;
support fetal development until the placenta is fully formed;
influence metabolic processes in a woman’s body that contribute to normal gestation;
prepare the mammary glands for breastfeeding by activating the development of the milk ducts.

The bioavailability of the active substance "Utrozhestan" is equally high for any method of administration, but after administration into the vagina, the hormone is absorbed faster and after 1 hour its concentration in the plasma becomes maximum. An increase in the amount of progesterone in the blood after oral administration occurs within 1-3 hours. The medication is excreted almost completely in the urine.

Pharmacodynamics and pharmacokinetics

The drug is a hormone of the corpus luteum . The hormone is able to penetrate into the nucleus of target organs and stimulate RNA and activate DNA .

Prajisan transfers the uterine mucosa to the secretion phase from the proliferative phase . Thus, specific conditions are created for the implantation of a fertilized egg to occur. The muscles of the uterus relax, the organ becomes less sensitive to the action of Oxytocin .

The active substance stimulates lipoprotein lipases , increases fat reserves, and activates the process of inducing Insulin Aldosterone production .

When the gel is applied to the mammary gland, there is a decrease in the proliferation and mitotic activity of the epithelium in the ducts. When taken orally, the permeability of the capillaries of the mammary gland tissue decreases, and the swelling of the connective stroma subsides.

The medicine is quickly and almost completely absorbed. Maximum concentration is achieved within two hours. The degree of binding of the hormone to blood plasma . The drug undergoes metabolic in liver tissue. The drug is excreted with bile and kidneys, with feces.

When using the drug vaginally, the active component accumulates in the uterus; an hour after administration, the maximum concentration of the substance is already blood

Features of use at different times

"Utrozhestan" refers to drugs that are allowed to be used throughout the entire gestational period, so it is prescribed both in the 1st trimester and at a later date. Quite often, such a medication is prescribed during preparation for conception, if pregnancy does not occur due to insufficient progesterone levels or any diseases of the uterus (endometriosis, fibroids).

In this case, treatment with Utrozhestan must be carried out under the supervision of a doctor. Prescribing it to yourself and using it just in case is unacceptable. The specialist must make sure that the woman has a progesterone deficiency and the use of such a hormone is really justified, because the threat of miscarriage is not always caused by a hormone imbalance. The cause may be genetic pathologies and then progesterone drugs do not help.

In the early stages, Utrozhestan is most often administered vaginally. This method reduces the load on the expectant mother’s digestive tract and ensures a faster effect of the medicine. In addition, oral use in the first months of pregnancy is often impossible due to severe nausea or frequent vomiting. The use of capsules helps eliminate hypertension and reduces the risk of possible miscarriage due to progesterone deficiency.

At the same time, no negative effects on the fetus are noted from the medicine.

In the 2nd trimester, Utrozhestan is used in cases where the production of progesterone by the placenta is insufficient. At this time, the drug is received by expectant mothers who are carrying a baby after IVF, as well as patients with cervical insufficiency. Indications for taking capsules in later stages are also various problems with a previous pregnancy, for example, if a woman suffered a miscarriage, she had surgical manipulations on the cervix, or she had a premature birth.

For some pregnant women, the drug is prescribed in the 3rd trimester. The use of "Utrozhestan" at this stage is necessary if the cervix has shortened and softened ahead of time, and the baby is located too low. These signs of a high risk of premature birth are the main reason to prescribe capsules in the third trimester, however, due to the risk of side effects, the medication is used only in situations that are dangerous for the woman and baby, when the benefits of treatment outweigh the possible harm.

What can be replaced

Very often, women have a logical question - why, for identical problems, one doctor prescribes Prajisan, and another - Utrozhestan. In fact, these two drugs are complete analogues, that is, they have absolutely no differences.

Therefore, it’s not even worth arguing - Prajistan or the drug Utrozhestan: which will be better. Everything is determined by the availability of this or that in the pharmacy. But there are some differences between Prajisan and Duphaston, which is also a progesterone substitute.

The second has several advantages:

various uses;
the price is a little lower.

As for the impact of side effects on a woman’s body, everything is individual. Both Prajisan itself and its analogues can cause an allergic reaction to individual components.

Prajisan 200 mg N10 is another dosage option for the drug. Prescribed in accordance with the characteristics of the woman’s body. The instructions give not only the characteristics of the drug, but also the symptoms of a possible overdose.

And this factor should be taken with full responsibility. This can be not only drowsiness, but also dizziness, a reduction in the menstrual cycle. What to do? Be sure to tell your doctor, he will allow you to reduce the dosage.

Contraindications

The reasons to refuse to take Utrozhestan are the following problems:

the woman has a tendency to blood clots, thrombophlebitis or thromboembolic pathologies have been detected (including in the past);
vaginal bleeding has been detected, but its cause has not yet been established;
an incomplete abortion occurred;
there is a suspicion of tumors of the genital organs, mammary glands, or a malignant neoplasm has already been diagnosed;
the patient developed porphyria;
the woman’s liver is damaged due to hepatitis or other serious illness;
hypersensitivity to progesterone or any inactive ingredient of the capsules has been identified.

In addition to these contraindications, there are also many diseases and pathological conditions for which capsules are used with caution. These include diabetes mellitus, heart disease, bronchial asthma, epilepsy, kidney failure, high blood pressure and many other ailments.

If the expectant mother has any concomitant diseases, then this must be taken into account when prescribing hormonal treatment.

Pros and cons of using the drug "Utrozhestan"

Although hormones are natural substances that are produced by our body, uncontrolled use is not at all safe and leads to various consequences. In rare cases, the expectant mother may experience a burning sensation, so taking utrogestan is limited to a maximum dose of 600 mg for 24 hours. Among the unpleasant sensations, the drug can cause dizziness, forgetfulness, drowsiness, and lethargy. Possible allergies, heaviness in the abdomen, jaundice, changes in body temperature.

The drug has a number of contraindications, including:

thrombophlebitis;
diabetes;
asthma;
diseased liver;
varicose veins;
problems with the cardiovascular system;
CNS diseases.

As studied drugs, utrozhestan has adverse reactions. However, they do not appear very often, and the drug is well tolerated. It is only necessary to take into account possible adverse reactions at the beginning of treatment and limit driving and work that requires an increased level of attention.

We also recommend reading the article on how duphaston works during pregnancy. From it you will learn about indications for use, adverse reactions, features of administration, as well as whether it can harm the health of the mother and fetus.

As for the fear of many mothers about weight gain, it is worth reassuring them: Utrozhestan is made on a plant basis, therefore it does not affect appetite and does not participate in carbohydrate and lipid metabolism. Adverse reactions are just minor ailments that are simply lost compared to the significance of the result!

Instructions for use

Capsules can be used in two ways:

swallow with water;
insert into the vagina as a suppository.

Oral administration is carried out at approximately the same time, and the dosage is selected individually. As a rule, a woman should drink most of the daily dose before bed, and a smaller part in the morning after waking up. For example, if a patient is prescribed 300 mg of progesterone per day, then she takes 100 mg in the morning, and 200 mg at night. Taking with food is not recommended, so capsules are taken either before meals or after meals.

Inserting the capsule into the vagina is simple and painless . After washing your hands, the drug is removed from the blister and then administered in a position convenient for the patient. In order for Utrozhestan to dissolve better and penetrate the vaginal tissues faster, after the procedure you need to lie down for a while or sit quietly.

Method of application for gel

Gel "Prajisan" is intended for intravaginal use. For added convenience, it is packaged in an applicator that cannot be reused.

To insert the gel into the vagina, you need to follow a simple procedure:

Open the package and take out the applicator.
Unscrew the cap.
Hold the applicator between your middle and thumb and place your index finger over the plunger.
The gel is inserted into the vagina while lying on your back. The knees should be slightly bent.
In order for the medication to enter the vagina, you must press the piston of the applicator.

After pressing, a small amount of the drug may remain inside the applicator. There is nothing critical about this. There is no need to try to somehow get it out or store it for the next use. The manufacturer has provided for this point, so the patient does not have to worry that an insufficient amount of progesterone has entered the body.

Utrozhestan for pregnant women - features of proper use

Utrozhestan is a hormonal drug from the group of gestagens. Utrozhestan is prescribed to pregnant women for hormonal imbalances during pregnancy, which can lead to spontaneous abortion (miscarriage). Utrozhestan is also used as the main drug for the treatment of infertility and in cases of artificial insemination to maintain hormonal balance in a woman’s body.

Utrozhestan is available in the form of capsules for oral administration, suppositories (vaginal suppositories), dosages of 100 and 200 mg. This form of release allows you to conveniently use the drug and select the required dose individually for each pregnant woman.

Prajisan or Utrozhestan

Both drugs are analogues of each other. Release form: capsules. Prajisan is additionally available in the form of a gel for vaginal use. Capsules can be used in the vagina. The auxiliary components differ in peanut oil (Prajisan) and sunflower oil (Utrozhestan). The drugs are available with a doctor's prescription! It is he who chooses which medicine is best to prescribe.

The country of origin of Prajisan is India. The drug Utrozhestan is produced in Belgium. The cost of Utrozhestan is from 187 rubles.

Which is better: Prajisan or Utrozhestan. Photo: vchemraznica.ru

The accuracy of the information has been verified by the editors of Filzor.ru

Utrozhestan and pregnancy

Why is Utrozhestan prescribed to pregnant women?

Utrozhestan is prescribed to pregnant women in cases where the patient’s body produces insufficient amounts of the main pregnancy hormone, progesterone. A decrease in progesterone levels leads to the fact that blood circulation in the inner layer of the uterus (endometrium) worsens, the fetus receives less nutrients and oxygen from the mother’s blood and, accordingly, grows and develops slowly. Also, a decrease in progesterone can cause bleeding, placental rejection, and increased uterine contractility.

Utrozhestan for pregnant women - what is it prescribed for:

prolong pregnancy;
prevent miscarriage;
improve blood supply to the uterus and placenta;
prevent bleeding;
reduce contractile activity of the uterus;
prevent premature birth.

Utrozhestan is prescribed from the first days of pregnancy. Most women with progesterone deficiency in the body can take this drug. If a woman suffers from infertility, then Utrozhestan is prescribed in combination with other hormonal drugs.

Can pregnant women take Utrozhestan?

Utrozhestan can be taken by pregnant women whose bodies do not have enough progesterone. However, caution should be exercised in patients who have a history of cardiovascular diseases (thrombophlebitis, stroke, myocardial infarction), malignant neoplasms of a hormonal nature, diabetes mellitus, chronic liver and kidney diseases.

Utrozhestan during pregnancy: effect on the fetus

Utrozhestan does not have a negative effect on the fetus. However, there is information that in the future, children born from a pregnancy maintained and prolonged by taking progesterone drugs may develop various disorders of the genitourinary system. So, if a girl is born, then during puberty she may develop ovarian cysts, and if a boy - urological diseases. The effect of Utrozhestan on infertility in such children has not been proven.

Utrozhestan: how to take during pregnancy?

To know how to take Utrozhestan correctly for pregnant women, you need to consult with your doctor. You should take the drug in the evening, before going to bed, with a small amount of water. If you use the medicine in the form of suppositories, they need to be inserted deep into the vagina at night.

In what doses should Utrozhestan be taken during pregnancy? The dosage for pregnant women is 100-600 mg. This is the daily dose, which should be divided into several doses.

For pregnant women, the dose depends on the disease and its severity. For example, to prevent premature birth in women at risk, 100-200 mg of Utrozhestan (in the form of vaginal suppositories) is prescribed. How much Utrozhestan should be taken by pregnant women also depends on the stage of pregnancy.

How long should you take Utrozhestan during pregnancy? In most cases, the drug is prescribed for the first and second trimesters, but it is possible to extend treatment for several weeks.

Utrozhestan during pregnancy: how to stop the drug?

When to stop the drug is decided by the attending physician. Once significant improvement has been achieved and a stable state has been achieved, the dosage can be reduced. In order not to harm the child and not cause withdrawal syndrome, it is necessary to reduce the dose by 100 mg per week or by 50 mg once every 3 days. You should stop tapering the drug and return to the initial dose if the following symptoms occur:

spotting, spotting;
nausea;
dizziness;
weight gain.

Utrozhestan: threat of miscarriage

Obstetrician-gynecologists often prescribe Utrozhestan when there is a threat of miscarriage. The dosage in such cases is 200-600 mg. The drug is taken every day at night. The dose of medication may vary depending on the degree of spontaneous abortion. Utrozhestan maintains pregnancy, improves blood circulation in the placenta, reduces the tone of the uterus and its contractile activity.

If there is no threat of miscarriage, then the drug Utrozhestan is not used to maintain pregnancy. If progesterone is normal, but there is a threat of miscarriage, then other hormonal therapy is prescribed.

Utrozhestan and the cervix: application features

A short cervix is one of the risk factors for the development of spontaneous abortion. Utrozhestan is prescribed for the cervix, as this drug has the following effects:

lengthens the cervix;
strengthens the cervix;
holds the neck.

This effect of the drug allows you to maintain and prolong pregnancy.

A little about progesterone

Observations have shown that most pregnant women produce insufficient amounts of the hormone progesterone.
After conception, the corpus luteum of the ovary is responsible for it, giving the woman an egg. Later, the placenta takes over the function. For a normal state, a certain stable dose of progesterone should be produced, but in no case less. The inability to supply the body with the necessary substances is the number one problem in the modern world. It is this factor that poses a threat to the normal course of pregnancy. Progesterone allows you to create ideal conditions for the fetus in a woman’s body. It is this hormone that is responsible for the condition of the uterus. It controls the tone of the uterus, calms the nerves and muscles (fallopian tubes, uterus, stomach). Allows you to create a healthy mucous membrane, participates in tissue growth, which is extremely important during pregnancy. Lack of progesterone results in delayed growth and development of the fetus. This is why progesterone, or the pregnancy hormone, is so important.

Utrozhestan during early pregnancy is prescribed to preserve the child, because it contains natural progesterone. It has proven to be quite effective in cases of threatened miscarriage. Mostly prescribed in the first two trimesters of pregnancy.

It is strictly forbidden to take any medications without a doctor’s prescription, especially when planning or in the early stages of pregnancy. Only a doctor can assess your condition and prescribe the use of the drug. Such remedies can be prescribed in combination with diet, vitamins, fitness, taking into account living conditions. Only together will the result be achieved. Do not self-medicate under any circumstances! Don't risk the health of your unborn baby. Always consult your doctor.

How to take Utrozhestan at the beginning of pregnancy?

Utrozhestan in the first days of pregnancy is prescribed to those women whose progesterone levels have been reduced since birth or those who have undergone an in vitro fertilization (IVF) program.

Utrozhestan is taken at the beginning of pregnancy in the form of vaginal suppositories. Use one suppository (100 or 200 mg) daily at night. The use of this form of release makes it possible to reduce the negative impact of the drug on the body of the mother and fetus (in particular, on the liver).

Cancellation of Utrozhestan in the first days of pregnancy can only take place in cases where the pregnant woman’s condition has stabilized and progesterone levels have returned to previous levels. The drug is discontinued gradually, reducing the dose by 100 mg weekly or by 50 mg every third day of therapy.

Side effects of Prajisan

In the first month of treatment, Prajisan capsules, according to reviews, can cause tension in the mammary glands and a decrease in the normal menstrual cycle.

A few hours after administration, drowsiness, slight dizziness and nausea may occur. The severity of these effects, as a rule, decreases when changing the dosage form of the drug.

In addition, Prajisan capsules, according to reviews, can cause:

Migraine;
Jaundice;
Feeling tired;
Fluid retention;
Skin rash;
Headache;
Itching.

When using Prajisan in the form of a vaginal gel, the following disorders may occur:

Abdominal pain (digestive system);
Drowsiness and headache (nervous system);
Intermenstrual bleeding, soreness of the mammary glands, irritation of the vaginal mucosa at the site of application (reproductive system).

The most typical allergic reaction during the use of Prajisan, according to reviews, is a skin rash.

Utrozhestan in the first trimester of pregnancy

Why is Utrozhestan prescribed in the first trimester of pregnancy? This drug is necessary to prevent the emergence of a new egg in the follicle and the start of a new menstrual cycle. Also, taking Utrozhestan in the first trimester reduces the contractility of the uterus and improves the development of the placenta and blood circulation in its vessels.

How to take Utrozhestan in the first trimester of pregnancy? There is no single dosage for all pregnant women. To prevent miscarriages in pregnant women with progesterone deficiency, 100-200 mg of Utrozhestan is prescribed, and for the treatment of spontaneous abortion - 300-600 mg. In the first weeks of pregnancy, it is especially important to take the optimal dose of medication, since too much or too little of the dose can lead to complications.

Prajisana price

The price of Prajisan is about 250 rubles for 10 capsules with a dosage of 200 mg.

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Prajisan capsules 200 mg 10 pcs. SUN Pharmaceutikal Industries Ltd.
RUB 252 order

Pharmacy Dialogue

Prajisan (caps. 200 mg No. 10)Sun Pharmaceutical Industries
RUB 235 order

Description of the drug

The main active ingredient of the drug Utrozhestan is progesterone. It is this hormone that is responsible for the normal course of pregnancy at various stages. The medicine is produced in the form of capsules with a soft shell and a stretchy base. These capsules usually have a yellow tint. Inside the gelatin shell there is an oily whitish suspension. It does not have a pronounced taste or smell.

At the beginning of pregnancy, gestagen (progesterone) has a positive effect on the structure of the uterine mucosa, which is necessary for the successful implantation of a fertilized egg. Later, it has a reducing effect on the contractility of the reproductive organ, which prevents increased tone and termination of pregnancy from developing. In addition, the hormone is directly involved in preparing the mammary glands for lactation.

The drug Utrozhestan is intended for oral administration or vaginal administration. The rate of absorption depends on the method of application. With vaginal administration, the desired therapeutic effect is achieved faster than when taking the hormone orally.

The instructions for use say that the main active ingredient of Utrozhestan is micronized progesterone. One capsule contains 200 mg of this hormone.

Since progesterone is extremely important during pregnancy, doctors often include this remedy in complex therapy. Among the excipients, the following components should be noted:

Titanium dioxide.
Sunflower oil.
Soy lecithin.
Gelatin and glycerol.

If the expectant mother is allergic to any of these substances, the use of the drug is strictly contraindicated. In this case, the gynecologist must select an analogue.

Prajisan drug interactions

When Prajisan is used orally, its effectiveness can be reduced by barbiturates, hydantoin, griseofulvin, carbamazepine, activated carbon and rifampicin.

The active component of the drug increases the pharmacological and therapeutic effects, as well as the toxic effects of theophylline, cyclosporine and troleandomycin.

When using Prajisan vaginally, it is not recommended to combine it with any other medications to avoid disrupting the release and absorption of progesterone.

Form of production

Utrozhestan 200 is available in the form of yellow capsules coated with a gelatin shell. They are enclosed in 14 pieces in blisters. The cardboard package contains 2 blisters.

Doctors prescribe the drug to women planning a baby or to mothers during pregnancy in conditions accompanied by a deficiency of progesterone in the body.

In this case, the doctor may prescribe the drug for oral or vaginal administration.

Internal introduction

Orally Utrozhestan 200 is taken in the following cases:

Infertility that develops in a woman due to a lack of the lutein hormone.
Treatment of premenstrual disorders.
Prevention of miscarriage or premature birth due to progesterone deficiency.
Bloody discharge at various times.
Premenopause.
Disruption of the ovulation process and other disruptions related to the menstrual cycle.
Threat of premature birth.

In addition, the medication is used as replacement therapy during the onset of menopause. In this case, Utrozhestan is taken in tandem with drugs containing estrogen.

Vaginal insertion

Often the medication is used for vaginal administration. In this case, the drug is administered directly into the vagina.

Doctors recommend this method of use in the following cases:

Prevention of miscarriage and premature birth in patients who are at high risk. This applies to cases of cervical insufficiency, as well as situations if the woman has a history of miscarriages or premature births.
Threat of abortion due to lack of progesterone in the body.
The patient's onset of early menopause.
As replacement therapy among women experiencing progesterone deficiency, for example, in the absence or non-functioning of one of the ovaries.
Before the upcoming artificial insemination procedure to maintain the duration of the luteal phase.
In combination with drugs containing estrogen, in replacement therapy for various disorders.

In addition, vaginal administration is recommended for the development of infertility due to luteal insufficiency. Utrozhestan should be prescribed exclusively by a specialist. Self-medication with this medication is strictly prohibited, as this can lead to the development of undesirable consequences in the patient.

Indications and dosage

The attending physician should prescribe the drug. You should not take the product yourself without proper consultation.

When to take

Uterine tone during pregnancy;
Preventative measure against uncontrolled abortion;
Prevention of fibroids;
Menstruation irregularities;
Endometriosis;
Infertility;
Cyclic pathological process;
Mastopathy;
Andropause;
Early onset of menopause;
Physiological process - postmenopause;
Climax;
Lack of sex hormone - progesterone.

Dosage

The dosage is personally prescribed by the attending physician for each patient. Any clinical case implies a different way of using the drug. Typically, the average dose of this medication is approximately 200 milligrams and should be taken in the morning and in the evening. As a rule, this occurs in case of a lack of hormones.

In other cases, such disorders as inconsistency of menstrual periods, mastopathy, premenopause and other ailments require taking 400 milligrams of medication. The duration of such therapy usually takes place within twelve days.

During replacement therapy, this drug is used together with estrogens. The dose in this case will be 200 ml. Therapy lasts approximately twelve days. As mentioned earlier, you can take the medicine in the form of suppositories. Now we will find out when they should be used and in what doses.

If a girl does not have the hormone progesterone at all, the medication must be taken as an addition to the chosen treatment. You need to drink the product in certain cycles. Each stage has a certain dosage, so you should carefully monitor the body’s reaction. On the fourteenth day of the cycle, the medication should be taken two hundred milligrams twice a day. Starting from the fifteenth and ending with the twenty-fifth day of the cycle, the medication is used one hundred milligrams once. After the twenty-sixth day and if it is possible to conceive a child, the drug begins to be taken in increasing order. The course of such therapy is sixty days, of course, this is a very long time, but nothing can be done.
During fertilization using IVF, as a rule, a kind of consolidation of the luteal phase is carried out. Taking the medication in the first two trimesters is the best time. As a rule, an injection of chronic gonadotropin is given first. The dose of the medication should start at 200 milligrams per day and end at 600 milligrams per day. But naturally, everything depends on the general condition of the expectant mother and the doctor’s recommendations.
It is better to take the product in the form of suppositories for infertility, as well as if there is a hormonal imbalance. The course of use of the medicine begins approximately on the seventeenth day of the cycle and lasts 10 days. If there is a delay in menstruation, the use of the medicine should not be interrupted.
If there is a threat of miscarriage or a lack of progesterone, suppositories are administered twice every day, the course of therapy is 6 months. It is worth emphasizing that the dosage is prescribed exclusively by the doctor, and he always takes into account the individual characteristics of the patient. It is prohibited to use the medication yourself, as this poses a danger not only to you, but also to your unborn child.

Pharmacological action of the drug

Why is the drug prescribed during pregnancy at different stages? During pregnancy, women usually use vaginal administration of the medication. For this, special candles are used. This type of treatment is carried out among expectant mothers for the following conditions:

The woman is at risk of miscarriage or spontaneous abortion.
Insufficient level of progesterone in the body.
History of termination of pregnancy due to progesterone deficiency.

If a girl has previously had miscarriages, Progesterone can be prescribed by a specialist as a preventive measure. Utrozhestan is used as an emergency if there is a threat of miscarriage.

In addition, the remedy in question is often used in the following situations:

Miscarriages during previous pregnancies.
Various complications during pregnancy due to progesterone deficiency.
Fertilization was done through IVF or this method was used in the past.
The girl's previous pregnancy ended in premature birth.
The development of infertility against the background of menstrual cycle disorders, namely its second phase.
Isthmic-cervical insufficiency.

The above indications are just a few items from the entire list. Utrozhestan can be prescribed by a doctor to a patient for other disorders. The product is often used, for example, when planning a baby to normalize hormonal levels.

Side effects

Negative reactions from the use of Utrozhestan for uterine tone rarely occur. More often than not, women speak positively about the hormonal drug. If we compare methods of use, then with oral administration the risk of adverse reactions is greater than with vaginal administration.

The manufacturer states that the medication can cause the following reactions:

allergy;
blood clot formation;
depressive states;
changes in the menstrual cycle;
headache;
decreased performance;
disturbances in the processes of bile excretion and bile formation;
changes in the condition of the skin;
sleep disorders.

When used vaginally, local reactions may develop. During pregnancy, women become especially sensitive, so the risk of such when treating uterine tone increases. Typically, patients complain of a burning sensation and itching. Such symptoms disappear after a few days of using the drug and, as a rule, do not require its discontinuation. When using medication for uterine tone in the second trimester, there is a risk of cholestasis in the unborn child. You should not independently treat uterine tone during pregnancy with Utrozhestan. To prescribe adequate therapy, it is recommended to consult a gynecologist, undergo an examination and receive individual recommendations.

Entry published by Lim-Lina · October 23, 2013

1,752 views

and background. In my city, I went to the doctor at 2-3 weeks from conception. She said that her lower abdomen was a little tight. She only told me to drink foliber and suppositories with papaverine and then when the pain starts. She didn't say any hormones.

The question is that I don’t know whether I should take these hormones or not? or go get tested to see what my level is? And tests only for progesterone? in general, everything you think about this situation and who has encountered it is very important to me!! I just don’t want to drink hormones that I may have enough of! Thank you!!

Use in different trimesters

Utrozhestan tablets or capsules are usually not used during pregnancy. More often during pregnancy, expectant mothers are prescribed suppositories. They can be used in the first, second and third trimester.

First trimester

In the early stages after conception, you can use it as prescribed by your doctor. Only a specialist can make a decision on prescribing medication based on the woman’s medical examination data.

In this case, it is recommended to insert suppositories into the vagina at the same time of day. This method of administering the hormone helps prevent the negative effect of the drug on the digestive system, in particular on the liver. In the right trimester, Utrozhestan is prescribed for the following purposes:

Prevention of increased uterine tone and elimination of this condition.
Normalization of the central nervous system.
Preventing miscarriage and premature birth.
Replenishment of progesterone in the body when there is a lack of it.

Utrozhestan does not have side effects on the fetus. This fact is confirmed by numerous medical studies. In extremely rare cases, a child develops a disorder such as an anomaly in the urethra.

Second trimester

In the second trimester of pregnancy, the drug is usually not taken. At this stage, a woman’s body, as a rule, does not experience a lack of progesterone. If this condition does occur, a specialist may prescribe Utrozhestan suppositories to the expectant mother.

In the second trimester, the medication can be prescribed to pregnant women in the following situations:

Development of isthmic-cervical insufficiency in the patient.
Disorder in the form of shortening of the cervix.
Fertilization was carried out using IVF.

In addition, when caring for a patient, the doctor must take into account the woman’s medical history. If she previously suffered a miscarriage, fetal failure or premature birth, Utrozhestan can be prescribed as a prophylaxis.

Third trimester

Starting from 30-34 weeks of gestation, a specialist can recommend that the expectant mother take the medication in question in the following situations:

Shortened cervix.
Too early softening of the reproductive organ and birth canal.
Low attachment of the placenta.

In this case, the regimen of use and duration of use of Utrozhestan is determined by the doctor depending on the severity of the woman’s condition. Reviews from experts indicate that the use of the product is justified only if the benefits of its use significantly outweigh the risks for the mother and fetus.

The need for treatment with this hormonal medication is assessed individually for each woman, depending on her disease.

To determine the required dosage and duration of treatment, a woman should consult a doctor. Under no circumstances should you take the drug on your own. This can cause extremely severe side effects. To achieve a therapeutic effect, you need to take the medicine correctly. The dosage for various conditions can be seen in the table.

Use of Prajisan during pregnancy and lactation

The use of Prajisan during pregnancy is not contraindicated, however, the instructions indicate the existing risk when taking the medication in the first four months of pregnancy. Based on the results of numerous epidemiological studies, no cases of abnormalities in child development were identified.

However, it should be borne in mind that Prajisan during pregnancy in the second and third trimesters can cause the development of liver diseases in the expectant mother.

There is no reliable data on the effect of the medication on a child during breastfeeding.