While carrying a child, many women face the problem of taking medications. After all, expectant mothers should not take most medications because of their toxic effect on the fetus. But, fortunately, there are drugs that can be used even when in an “interesting” situation. One such medicine is Utrozhestan.
Often on women's forums you can find the following questions: why are Utrozhestan suppositories prescribed during pregnancy? Which is better: Utrozhestan or Duphaston? Let's figure it out.
Utrozhestan is a hormonal drug that increases the level of progesterone in the blood, stimulates the functioning of the uterus and its mucous membrane. Duphaston has similar indications. But only the gynecologist decides which drug should be prescribed to a particular patient.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
of the progesterone it contains , which is an analogue of the natural biological progesterone produced by the corpus luteum of the ovaries after ovulation, and also, in pregnant women, by the placenta.
Under the influence of progesterone, the mucous membrane lining the uterine cavity thickens and becomes secretory, which contributes to the fixation of the fertilized egg in it and the normal development of pregnancy in the future.
In pregnant women , progesterone reduces the contractility and excitability of the muscles of the uterus and fallopian tubes.
hormones that regulate the release of FSH and LH , suppresses ovulation and the production of gonadotropins by the pituitary gland. Androgenic properties are not detected.
Pharmacokinetics when taken orally
Plasma concentrations of progesterone begin to increase from the first hour after taking the capsules and reach maximum values after 1-3 hours. After an hour, this figure is 4.25, after two hours - 11.75, after four hours - 8.37, after six hours - 2, and after eight hours - 1.64 ng/ml.
Two-thirds of the taken dose of progesterone is metabolized in the liver. Mainly pregnenolone and pregnanediol (metabolites identical to those formed during physiological secretion).
These progesterone play an important role in the formation and metabolism of other steroid hormones . From 15 to 60% of metabolic products are excreted by the kidneys, a little less than a third - with feces.
Pharmacokinetics for intravaginal use
progesterone is absorbed into the mucosa. Absorption is fast. Plasma concentration begins to increase from the first hour after administration of the drug. Its level reaches its highest values after 1-3 hours.
The use of Utrozhestan 100 mg capsules at night allows you to achieve and maintain a stable and physiological concentration of progesterone in the plasma, which corresponds to that in the corpus luteum phase (luteal phase) of the cycle in women with normal ovulation.
Thus, the medicine stimulates adequate maturation of the internal mucous membrane of the uterus and promotes normal implantation of the embryo.
Using a dose exceeding 200 mg/day, intravaginal use of Utrozhestan does not allow achieving plasma progesterone that would be identical to those in the first 3 months of pregnancy.
Metabolic products in urine and blood plasma are identical to those found in physiological fluids during the formation of endogenous progesterone .
About 95% of the dose is excreted in the form of metabolites (the main one is pregnanediol ) in the urine.
Characteristics of the drug
The active element of this medication is the granulosa cells of the ovarian follicle, which produce an endogenous steroid. When it enters a woman’s body, it helps normalize secretory transformations in the uterine cavity.
Enhances the transformation of the mucosal layer, which promotes the formation and process of formation and growth of the embryo. During pregnancy, it reduces the tone of the uterus and causes the end sections of the milk ducts in the breast to transform.
In the process of restoring the normal level of the biologically active form of testosterone, which blocks the production of pituitary gonadotropins, leading to a decrease in androgen levels. The antimineralocorticoid effect is manifested by increased urine output.
Indications for use
Utrozhestan: why is it taken orally?
In obstetric practice, Utrozhestan is used to prevent the threat of miscarriage or normal miscarriage against the background of luteal phase deficiency (LPF), as well as to prevent the threat of premature birth .
Also, oral administration of the drug is indicated for gynecological disorders associated with progesterone , including PMS, menstrual irregularities (dys- or anovulation), breast disease, premenopausal conditions; infertility caused by luteal insufficiency; HRT in women with menopausal disorders (in combination with estrogen -containing drugs).
Indications for use of Utrozhestan vaginally
As a suppository, Utrozhestan is used:
- for hormone replacement therapy for non-functioning ovaries as part of the oocyte donation ;
- during IVF (to maintain the corpus luteum phase in preparation for fertilization of the egg);
- to maintain the corpus luteum phase in the induced/spontaneous cycle;
- for the prevention of spontaneous/habitual miscarriage caused by gestagen insufficiency ;
- for endocrine infertility ;
- for endometriosis ;
- with uterine fibroids ;
- if there are restrictions for oral use of the drug or if it is not possible.
Contraindications
Contraindications to the use of Utrozhestan:
- severe liver dysfunction;
- vaginal bleeding of unknown origin;
- incomplete/failed abortion ;
- cerebral hemorrhage;
- thromboembolic disorders;
- thrombophlebitis;
- neoplasia of the genital organs/mammary glands (confirmed or suspected);
- porphyria;
- hypersensitivity to any of the substances contained in the capsules.
Compound
The composition of the drug Utrozhestan includes:
- endrogenic steroid;
- progestogenic sex hormone;
- paste made from ground peanut seeds;
- food additive soy emulsifier lecithin;
- trihydric alcohol propanetriol;
- hydrolyzed collagen protein;
- titanium white.
Side effects of Utrozhestan
Side effects of Utrozhestan when administered orally most often manifest themselves as:
- changes in the menstrual bleeding cycle;
- bleeding starting in the middle of the cycle;
- amenorrhea;
- headache.
Less commonly noted:
- transient dizziness ;
- drowsiness;
- itching;
- mammalgia;
- acne;
- diarrhea / constipation ;
- vomit;
- cholestatic jaundice.
In rare cases, nausea may occur.
The category of extremely rare side effects (no more than 1 in 10 thousand women) includes depression, chloasma, and urticaria .
The possibility of changes in libido, the appearance of chest discomfort and/or symptoms characteristic of PMS, hyperthermia, alopecia , insomnia , hirsutism , pulmonary embolism , venous thromboembolism , changes in body weight, gastrointestinal disorders, fluid retention, anaphylactic hypersensitivity reactions cannot be excluded. type.
Transient dizziness and/or drowsiness are especially pronounced with concomitant hypoestrogenism . To eliminate these phenomena (without reducing the therapeutic effect), it is usually sufficient to increase the dosage of estrogen or reduce the dose of the drug.
If treatment is started before the 15th day of the cycle, the cycle may be shortened. Occasional bleeding may also occur.
If Utrozhestan tablets are inserted into the vagina, side effects are expressed in the form of hypersensitivity reactions (hyperemia, itching, burning) and the appearance of oily discharge.
Reviews of the side effects of Utrozhestan (including during pregnancy) allow us to conclude that the greatest number of unpleasant phenomena occur after taking the capsules orally. To reduce their severity, capsules should be taken before bed or switch to intravaginal administration.
Utrozhestan capsules: instructions for use
The method of administration, as well as instructions on how best to take Utrozhestan, how long to continue treatment and how to discontinue the drug, depend on the indications for use and the clinical manifestations of the pathology.
Instructions for using Utrozhestan orally
Orally, as a rule, the drug is prescribed to be taken at a dose of 200-300 mg/day. The main dose (in the evening, before bed) is 200 mg, in the morning (if necessary) another 100 mg is taken.
For luteal insufficiency (PMS, FCD, premenopause, cycle disruptions), tablets are taken in ten-day courses, starting from the 17th day of the cycle.
For HRT during menopause , due to the fact that separate therapy estrogen -containing drugs is not recommended, Utrozhestan is used as an addition to the main treatment.
You should start taking the drug 7 days after the start of each course of HRT. Duration of use: 2 weeks. It should be remembered that withdrawal bleeding is possible during HRT.
To prevent premature birth (PL), the drug is taken 3-4 times a day, at regular intervals. Single dose - 400 mg. After the disappearance of clinical manifestations of the threat of PR, the dose is gradually reduced to a maintenance dose of 600 mg/day: continue to take one capsule 3 times/day.
Regarding the week before which to take the drug, the instructions provide the following recommendations: during pregnancy at a dose of 600 mg/day. possible up to 36 weeks.
The use of progesterone for a period exceeding 36 weeks is not recommended.
How to properly administer Utrozhestan capsules intravaginally?
The capsules are inserted into the vagina as deeply as possible. The average daily dose of the drug for intravaginal use is 200 mg (1 capsule 200 mg 1 time / day or 2 capsules 100 mg 2 times / day). If necessary, you can use an applicator for greater convenience.
Depending on the woman's response to the prescribed treatment, the dose may be increased.
In case of partial NLF (“ovulation syndrome”, cycle disruptions), Utrozhestan is used for 10 days at a dose of 200 mg/day. Treatment begins on the 17th day of the cycle.
For complete NLF in women with absent (non-functioning) ovaries ( oocyte donation ), 100 mg of progesterone is prescribed in the morning and evening from the 15th to the 25th day of the menstrual cycle.
If pregnancy is confirmed on the 26th day of the cycle, from that moment the dose is gradually increased by 100 mg/day, bringing it to a maximum of 600 mg/day. (one capsule 200 mg per dose).
At this dosage, Utrozhestan suppositories continue to be used until day 60.
During an IVF cycle, 1 capsule of 200 mg is administered once every 8 hours.
During pregnancy, when there is a possibility of its termination, as well as to prevent habitual miscarriage associated with progesterone deficiency, a woman up to 12 weeks should be administered 100 or 200 mg of progesterone every 12 hours.
It is very important to correctly insert the capsules into the vagina, especially when the drug is prescribed for hormonal support during IVF. Before inserting the capsule, you should lie on the bed, placing a pillow under your buttocks and lower back, spread your legs wide and place the tablet as deeply as possible into the vagina.
After this, in order for the active substance of the drug to be absorbed into the mucous membrane in the required volume, it is recommended to remain in bed in the same position for another 15 minutes to an hour.
Medicinal properties
The drug belongs to the gestagenic group. The active component of Utrozhestan is the hormone progesterone, synthesized by the corpus luteum. After penetration, it enters target cells, where it binds to DNA and stimulates the construction of RNA.
The substance transfers the uterine mucous tissue into the secretory phase from the proliferation stage, which helps to normalize the condition of the endometrium and the formation of a layer necessary for a successful pregnancy. After fertilization of the egg, it ensures its proper development. The hormone reduces the contractile function of the muscles of the uterus and tubes, triggers mechanisms that prepare the mammary glands for lactation.
In addition, Utrozhestan promotes the accumulation of fat necessary for pregnancy, increases glucose consumption, promotes the deposition of glycogen in the liver, increases the formation of gonadotropes, and reduces the nitrogen content in the body.
Oral administration
After ingestion of the capsule, the active substance is absorbed from the gastrointestinal tract. Plasma concentration is formed within an hour. progesterone forms two active metabolites that have properties identical to the endogenous hormone. Derivative substances are almost completely (95%) excreted from the body in the urine.
When inserted into the vagina
After release from the capsule, progesterone is quickly absorbed and accumulates in the uterine cavity. The highest level of the hormone is also formed an hour after the administration of the suppository. When Utrozhestan is administered at 100 mg twice a day, the average concentration is maintained throughout the day. If the drug is administered more than 200 mg per day, the progesterone level corresponds to the first stage of pregnancy. Metabolites are also excreted from the body in the urine.
Overdose
Symptoms of overdose may be manifested by symptoms of side effects of the drug: drowsiness, euphoria, dizziness, metrorrhagia , shortened cycle duration, dysmenorrhea .
For some women, the standard dose may be too high due to existing or secondary endogenous secretion of progesterone , hypersensitivity to Utrozhestan or concomitant decreased blood levels of estradiol .
If transient dizziness or drowsiness occurs, it is enough to reduce the dose of progesterone or prescribe the drug in the evening (before bedtime).
If the cycle is shortened and metrorrhagia is present, the start of treatment is postponed to a later day of the cycle (for example, from day 17 to day 19).
In premenopausal patients receiving HRT, estradiol levels should be monitored.
Interaction
with estrogen-containing drugs during menopause progesterone no later than the 12th day of the cycle .
If, when treating the threat of PR, the drug is combined with β-adrenergic agonists , the latter can be used in a lower dose.
The simultaneous use of other drugs may disrupt the pharmacokinetics of progesterone , causing an increase or, conversely, a decrease in its plasma concentration and, thus, leading to a change in the effect of the drug.
Drugs that potently induce liver enzymes antiepileptic drugs , barbiturates , Phenylbutazone , Griseofulvin , Rifampicin , Spironolactone ) enhance the metabolism of progesterone in the liver.
Certain antibiotics (in particular, tetracyclines , ampicillins ) can disrupt the balance of intestinal microflora , as a result of which the enterohepatic steroid cycle .
It is known that these drug interactions are individual and can differ significantly in different categories of patients. It is impossible to unambiguously predict their possible clinical manifestations.
All progestin drugs tend to reduce glucose tolerance, which may result in the need to increase the single dose of oral hypoglycemic agents and insulin in patients with diabetes mellitus .
Smoking reduces the bioavailability of progesterone , while alcohol increases it.
special instructions
Treatment in recommended doses does not provide a contraceptive effect.
Due to the likelihood of metabolic disorders and thromboembolic complications, it is necessary to discontinue the drug if:
- visual impairment, including loss of vision, double vision, vascular lesions of the retina , papilledema , proptosis ;
- thrombotic or thromboembolic venous complications (regardless of which area is affected);
- high intensity headache, migraine .
Patients with a history of thrombophlebitis
The absence of menstruation during treatment with Utrozhestan requires testing to confirm or exclude pregnancy, which may be the cause of amenorrhea .
More than 50% of spontaneous abortions in early pregnancy are caused by genetic complications. In addition, mechanical disorders and infectious diseases . In such cases, the use of progesterone is justified only in cases where there is a delay in the expulsion of the fertilized egg.
Based on this, the prescription of Utrozhestan, on the recommendation of a gynecologist, should be provided for cases when a woman’s body produces an insufficient amount of progesterone .
Capsules should not be taken with food. The optimal time to take it is before bedtime. Simultaneous consumption of food increases the bioavailability of Utrozhestan.
Some women are interested in whether the drug affects hCG levels. Doctors say that Utrozhestan does not change the results of a blood test for hCG .
Utrozhestan is leaking - what to do?
All patients note that the drug leaks out when used intravaginally. The manufacturer and doctors say that this phenomenon is the norm. The appearance of oily discharge is associated with the dosage form of Utrozhestan and its composition, which contains fatty substances - vegetable oil and soy lecithin.
Some women worry that this may reduce the effectiveness of Utrozhestan. However, even here doctors rush to reassure, assuring that it is not the active substance that is leaking out, but only the capsule shell.
In some cases, when the drug is used several times a day, the doctor may recommend intravaginal administration only 1 time per day - before bedtime, and at other times - in the morning and afternoon - oral administration of capsules.
Utrozhestan and menstruation
Utrozhestan is prescribed for the correction of cycle disorders caused by a deficiency of endogenous progesterone , as well as for the correction of disorders caused by excessive production of estrogen .
A delay in menstruation while using the medication may indicate pregnancy. In this case, the woman must donate blood to determine the level of hCG or take a pregnancy test .
The situation when there are no periods after using the drug can also be a consequence of “blind” support for the 2nd phase of the cycle, when the time of ovulation is not taken into account.
For women planning a pregnancy, doctors recommend taking Utrozhestan not from the 16th day, but one day after ovulation.
Progesterone medications can be used to induce menstruation. Menstrual bleeding is caused by the withdrawal effect of Utrozhestan. The onset of menstruation usually occurs 2-10 days after stopping taking the capsules.
Analogues of Utrozhestan
Matches by level 4 ATX code:
Iprozhin
Crinon
Prajeesan
Progesterone
Depo-Provera
Progestogel
Structural analogues: IPROZHIN , Crinon , Progestogel , Progesterone , Prajisan .
Analogues with a similar mechanism of action: Oxyprogesterone capronate , Medroxyprogesterone-LENS .
Prajeesan and Utrozhestan - difference?
Prajisan belongs to the group of progesterone and is a generic version of Utrozhestan. Therefore, the difference between these means is small.
Prajisan , unlike its structural analogue, is available not only in the form of capsules for oral administration and intravaginal use, but also in the form of a gel, which is inserted into the vagina using a disposable applicator.
Which is better - Crinon or Utrozhestan?
The drug Crinon is a vaginal gel produced by the manufacturer in disposable applicators. The active substance is progesterone , which is contained in the medicine at a concentration of 90 mg/dose (1 dose = 1.125 g of gel).
A special feature of the drug is that the gel is placed in a polymer delivery system, which ensures a high degree of binding to the vaginal mucosa and continuous release of the active substance for at least three days.
Iprozhin or Utrozhestan - which is better?
Iprozhin are capsules containing 100 or 200 mg of progesterone (micronized). The main difference between the drug and Utrozhestan is that when used intravaginally, it practically does not flow out of the vagina, which, according to many women, is more convenient.
The annotation for Iprozhin states that it is able to enhance the effect of immunosuppressants , diuretics , anticoagulants and antihypertensive drugs , as well as reduce the lactogenic effect of Oxytocin .
Release forms
Hormonal drugs are produced in the form of capsules, which, depending on the purpose, can be taken orally or used as suppositories for intravaginal use. Therefore, if Utrozhestan is used vaginally, it is called suppositories, and when used orally, it is called capsules.
100 mg capsules are soft round pills in a pale yellow body. The filling is a homogeneous, oily suspension of whitish color. The medicine is packaged in blisters. A pack with instructions contains 28 or 30 capsules.
Utrozhestan suppositories (or capsules) containing 200 mg of progesterone differ from the first drug only in the shape of the capsules - they are oval. Otherwise, they are similar - they also have a pale yellow body and a whitish suspension as a filler. The product is packaged in blisters of 7 pieces. The pack contains 2 records and instructions for use.
Utrozhestan during pregnancy
Does Utrozhestan help you get pregnant?
When planning pregnancy, Utrozhestan is necessary when tests reveal insufficiency of the 2nd phase of the cycle.
The use of the drug stimulates the formation of the secretory type endometrium, promotes the transition of the uterine mucosa from the proliferative to the secretory phase, and then, when fertilization occurs, its transition to a state optimal for the development of the fertilized egg.
The endometrium, which swells under the influence of Utrozhestan, becomes loose, making it easier for the egg to attach to the wall of the uterus.
In addition, Wikipedia indicates that progestins also help reduce the excitability and contractility of the muscles of the uterus and fallopian tubes, prevent an increase in the concentration of estrogen in the 2nd phase of the cycle and promote nervous relaxation, thus creating conditions favorable not only for conception, but also for maintaining normal course of pregnancy.
Analyzing reviews of those who were helped to get pregnant by Utrozhestan, we can conclude that the drug is effective in situations where the cause of infertility is a low level of endogenous progesterone . If there are no other obstacles to conception, pregnancy occurs quite quickly with the use of the medicine.
How to take the drug when planning pregnancy?
Recommendations regarding how to take Utrozhestan to become pregnant are determined by the severity of endogenous progesterone .
As a rule, when trying to get pregnant, the drug is taken for ten days in each cycle, starting from the 16th day. On days 25-26, you should take a pregnancy test or donate blood to determine the level of hCG.
If pregnancy is not confirmed, the drug is stopped and resumed in a new cycle, adhering to the same dosage regimen.
If there is reason to suspect pregnancy, you should not stop taking Utrozhestan - abrupt withdrawal during pregnancy can cause spontaneous abortion. If the test is positive, use of the drug is continued for up to 12-16 weeks.
of progesterone necessary to maintain pregnancy precisely on the walls of the uterus.
For women whose ovaries do not produce progesterone , Utrozhestan is prescribed intravaginally according to the following scheme:
- 100 mg/day. on days 13 and 14 of the cycle;
- 200 mg/day, divided into 2 doses, from days 15 to 25;
- from 200 to 800 mg/day. (the dose is increased daily by 100 mg to the maximum) - from day 26 (provided that pregnancy is confirmed).
How to take Utrozhestan during pregnancy?
The use of Utrozhestan during pregnancy does not have a negative effect on the fetus. If it is necessary to use it after the third month of pregnancy, monitoring the functional state of the liver is necessary.
There is evidence that the use of progestogens in pregnant women to prevent habitual/spontaneous miscarriage due to NFL can lead to the development of hypospadias .
In the early stages, if there is a threat of miscarriage, it is recommended to use the drug vaginally, since with this method the therapeutic effect develops faster, and the load on the liver is minimal. It is also recommended to prescribe suppositories to women who suffer from severe toxicosis .
The treatment regimen and dosage for each specific patient are selected individually by the doctor.
When it comes to maintaining pregnancy, the initial dose is usually between 400 and 600 mg. Subsequently, the woman is transferred to maintenance treatment at a dose of 200 mg/day. up to 600 mg/day. If therapy is ineffective, the dose can be increased to 0.8-1 g/day. Treatment usually lasts up to 18-20 weeks.
In the 2nd and 3rd trimester, the use of Utrozhestan is advisable when the clinic for the threat of miscarriage resumes, as well as in a situation where a woman develops ICI ( isthmic-cervical insufficiency ).
The method of administration does not matter at this time. Feedback from doctors and their patients allows us to conclude that the use of the drug in a daily dose of up to 300 mg up to 36 weeks inclusive is equally effective both when taking capsules orally and when inserting them into the vagina.
Until 34-36 weeks, until the uterine tone is relieved, 1 capsule is taken orally every 8 hours. Then the woman is prescribed maintenance treatment at a dose of 200 mg.
Side effects of the drug
The most common side effects of Utrozhestan are drowsiness, lethargy and dizziness. However, these unpleasant symptoms occur exclusively when taking capsules orally.
Since Utrozhestan is a hormonal drug, the question naturally arises: is it possible to recover from it? Doctors say that taking the capsules does not cause changes in body weight. This is due to the fact that the drug does not affect the metabolism of carbohydrates and lipids, and also does not retain fluid in the body.
Discharge during pregnancy after the drug (with intravaginal administration) is not a side effect if it does not contain bloody impurities - it is simply a melted capsule shell. The appearance of bleeding requires dose adjustment.
How much to take Utrozhestan during pregnancy?
Only a doctor can say exactly until when to take Utrozhestan during pregnancy in a particular case. If pregnancy occurs during treatment with progesterone , capsules continue to be taken for an average of 2 months, starting from the 26th day of the cycle in which conception occurred.
How to stop taking medication during pregnancy?
During pregnancy, Utrozhestan is discontinued by gradually reducing the dose, since sudden cessation of treatment is fraught with spontaneous termination of pregnancy.
The withdrawal regimen may include a dose reduction every three days by 50 mg or a weekly reduction by 100 mg.
What is better - Duphaston or Utrozhestan during pregnancy?
Duphaston , like its analogue, is used to compensate for the deficiency of endogenous progesterone .
The main difference between the drugs is that the first is a synthetic analogue of progesterone progesterone today that is obtained from plant materials.
The effectiveness of Duphaston and Utrozhestan in planning pregnancy and in pregnant women is comparable.
The advantages of Duphaston are the absence of sedation, which when using Utrozhestan is manifested by drowsiness and lethargy, as well as long-term experience with use.
The advantages of Utrozhestan are the ability to influence androgen metabolism and suppress the effects of oxytocin , thus improving the course of pregnancy.
Use during lactation
The ability of progesterone to pass into breast milk has not been studied, and therefore the use of the drug should be avoided during breastfeeding .
Features of use during pregnancy
During pregnancy, it is necessary to take the drug in the following situations:
- threat of spontaneous abortion;
- as a prophylactic against the threat of miscarriage;
- inflammatory manifestations of the uterine cavity;
- inflammation of the ovaries and fallopian tubes;
- to relieve uterine tone.
Utrozhestan has restrictions on its use during pregnancy.
Such manifestations include:
- varicose veins of the lower extremities in acute and chronic course;
- encephalopathy;
- dysmetabolic encephalopathy;
- thrombosis;
Utrozhestan during pregnancy is contraindicated in case of thrombosis of the lower extremities - inflammatory diseases of the respiratory system with asthmatic manifestations;
- dystrophic changes in the myocardium;
- cardiomyopathy;
- vegetative-vascular dystonia;
- astheno-neurotic syndrome;
- valvular heart disease;
- liver problems;
- toxicosis.
Reviews about Utrozhestan
On the forums, the majority of reviews about Utrozhestan are positive. The drug is effective for endometriosis , cycle disorders caused by progesterone , and when planning pregnancy.
It also helps normalize a woman’s hormonal levels during menopause and is used to maintain phase 2 of the cycle, when IVF is used to conceive.
Reviews about Utrozhestan during pregnancy are also extremely positive. Most women believe that only thanks to the use of the drug in the first weeks of pregnancy they were able to save and carry a child.
The drug has a unique molecular structure, due to which it normalizes the exchange of steroid male sex hormones that are present in the body of a pregnant woman, and thus contributes to the normal course of pregnancy and improvement of skin condition.
The ability to interact with the same receptors with which androgens makes it advisable to use Utrozhestan, including in women suffering from hyperandrogenism .
Reviews from doctors and reviews from pregnant women who took Utrozhestan in late pregnancy suggest that one of the most important properties of the progesterone is its tocolytic activity.
In late pregnancy, the tocolytic effect is especially necessary for women who do not tolerate antiprostaglandins and β-mimetics or have contraindications to the use of these drugs.
The advantages of the drug are different dosages of the active substance in capsules (100 mg and 200 mg), as well as the ability to use them orally and as vaginal suppositories.
The only drawback is, perhaps, the side effects, which manifest themselves in the form of dizziness, lethargy and increased drowsiness. It should be noted, however, that such phenomena occur exclusively with oral administration of Utrozhestan.
Drug withdrawal regimen
If a woman used the drug Utrozhestan from 14 to 28 weeks of pregnancy, she needs to smoothly and gradually reduce the dose of the medicine.
For example: a pregnant woman takes 0.4 g of the hormonal drug Utrozhestan per day, then in the next week the dose must be reduced by ¼. And this must be done every next 7 days until the drug is completely discontinued.
Doctors usually advise starting to reduce the dose of Utrozhestan no later than 30 weeks of pregnancy, or even earlier. When discontinuing the drug, spotting usually appears, which should not be considered a pathological process - the discharge will go away on its own in a couple of days.
The drug Utrozhestan for planning pregnancy and its further gestation, as well as as a drug for hormonal pathologies in women, has proven itself to be an effective remedy.
Article design: Vladimir the Great
How much does Utrozhestan cost?
The cost of the drug in different cities of Ukraine is practically the same. For example, the price of Utrozhestan 200 mg in Kharkov, Lugansk, Odessa or Dnepropetrovsk for package No. 14 varies from 270 to 285 UAH. You can buy 100 mg capsules in Kyiv and pharmacies in other regional centers for an average of 280 UAH.
Price Utrozhestan 100 mg in Russia – 370-400 rubles. Suppositories (tablets) 200 mg cost 400-450 rubles.
The price of Utrozhestan 100 mg in Belarus is 150-225 thousand rubles, Utrozhestan 200 mg is 162-240 thousand rubles.
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ZdravCity
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