Mechanism of action of Duphaston
For the onset and normal course of pregnancy, the body of the expectant mother needs progesterone. Normally, it is produced in the ovaries, and during fertilization its concentration increases significantly. After fertilization, the function of producing the hormone is taken over by the corpus luteum until the placenta is formed, producing the substance in the future.
Duphaston is a drug whose main active ingredient is dydrogesterone. This substance belongs to the synthetic analogues of progesterone.
Duphaston is available in tablet form. Upon penetration into the gastrointestinal tract, the medicine is quickly absorbed into the bloodstream. The maximum effect of the drug is observed after 2 hours. Dydrogesterone takes over the function of progesterone. It supports the onset of ovulation and helps prepare the uterus for the implantation of a fertilized egg in it.
After pregnancy, Duphaston provides the necessary concentration of progesterone in the woman’s body. Its action is as follows:
- preparing the mammary glands for future lactation;
- relaxation of the uterus;
- ensuring stretching of the uterus;
- maintaining internal processes aimed at producing nutrition for the fetus.
Pregnancy after stopping duphaston? For all
One of the popular methods of “treatment” or creating the appearance of it among most doctors is the so-called “pregnancy maintenance”. Most often - Duphaston. Doctors often prescribe pills to everyone without any reason, without bothering themselves with “unnecessary examinations” in order to create the appearance of “treatment” and rather relying on the old Russian “maybe it will help”, “it won’t be superfluous”, “it won’t will harm” and so on, than guided by common sense or necessity.
If the corpus luteum phase is shorter than 10 days or the level of progesterone in the blood is below normal (and ovulation definitely occurs), the doctor prescribes hormonal progesterone drugs (for example, progesterone injections or utrozhestan).
The key point and the biggest “mistake” in searching for any “defects” in the phase of the corpus luteum in a woman is the incorrect determination of the length of the follicular phase and the timing of ovulation in each individual cycle (regardless of whether there were violations or delays before).
By starting to take any hormonal medications before ovulation, a woman risks not only not achieving the desired effect - pregnancy, but also harming her hormonal health. In the case of progesterone drugs, in the best case, you can get a “contraceptive” effect in the current cycle, in the worst case, hormonal disorders in the future. After all, progesterone and its analogs prevent the further release of eggs, and the reaction of the female body to unexpected interference in natural processes from the outside can be completely unpredictable.
1. A blood test for progesterone is taken in the MIDDLE of the second phase - approximately 7 days after ovulation (7 days before the start of the next menstruation). The results of an analysis carried out several days earlier or later than this period may turn out to be less objective (severely underestimated). To exclude the possibility of error, ovulation must be monitored in advance. If after taking the test, menstruation occurs later than 10 days, and even more so - if more than 2 weeks later (if the test was taken without tracking ovulation using ultrasound or ovulation tests) - it is better to retake the test. To be sure of the objectivity of the results, it is better to take this analysis several times in one cycle (with an interval of a couple of days) and several cycles in a row to eliminate errors in the laboratory and have a more complete picture.
The dosage of the drug is usually determined by the doctor depending on the circumstances and characteristics of the body. It is recommended to continue taking the drug until the presence or absence of pregnancy is determined (tests, blood test for hCG, ultrasound).
The most common drugs now are progesterone in ampoules, utrozhestan (natural progesterone in capsules), Duphaston (synthetic drug).
Manufacturers claim that, unlike other synthetic analogues of progesterone, Duphaston “does not affect” ovulation. At least, these are the statements you can find from the manufacturer - both in the annotations for the drug and on the official website, including most of the pages in the “questions and answers” section. But in reality THIS IS NOT EXACTLY SO. “... Clinical studies have shown that Duphaston does not suppress ovulation at normal therapeutic doses. According to Adolf E. Schindler, dydrogesterone can affect ovulation in a daily dose exceeding 30 mg
That is, if, by a happy coincidence, such a “treatment” may not have a negative impact on a healthy, hardy organism, then even in the presence of any hormonal disorders, a deterioration of the initial situation is possible - for example, thoughtless use of the drug can disrupt ovulation not only in the cycle with taking drug, but also lead to further violations.
Why do you need the drug before and during pregnancy?
Some women's bodies are unable to produce enough progesterone, making it difficult to conceive and maintain a pregnancy. The reasons for this phenomenon may be different. Hormonal deficiency can occur as a result of chronic pathology, severe stress, or genetic predisposition.
Before the invention of artificial hormones, women with a lack of progesterone could not become pregnant. If pregnancy did occur, it ended in miscarriage. Duphaston gives many women the opportunity to safely carry a baby. It is prescribed both at the stage of pregnancy planning and after its onset. Before pregnancy, the drug is used to diagnose pathologies associated with hormonal imbalance:
- lack of progesterone in the luteal phase;
- endometriosis;
- uterine bleeding;
- severe premenstrual syndrome;
- menstrual irregularities or absence of menstruation for a long time without pregnancy;
- miscarriage that happened.
Indications for taking the drug
Duphaston is prescribed during pregnancy only if there is a threat of miscarriage. The symptoms are:
- Nagging pain in the lower abdomen;
- Bloody discharge;
- Uterine tone.
The appointment is made by the doctor after a preliminary examination. If time permits (after 4 weeks), a vaginal ultrasound is performed. The gynecologist must make sure that the fetus has a heartbeat and there is no placental abruption. If the period is short, a specialist conducts an examination in a gynecological chair. In this case, it is clear that the pharynx is closed, the uterus is only slightly increased in size.
An hCG test is also required. It is he who shows the level of progesterone in the blood. If there is a threat of miscarriage, it is carried out every 2 days, positive dynamics should be observed. If the indicators decrease or remain unchanged, the amount of the drug must be increased.
If a woman took Duphaston while planning a pregnancy, abruptly stopping it can lead to serious problems. The withdrawal regimen should be selected by the treating gynecologist.
Contraindications for use
The list of contraindications for taking the drug is small. The main warnings concern the body's possible reaction to the auxiliary components. Duphaston contains lactose, which can cause allergies. For this reason, it is contraindicated for people with lactose intolerance. Other contraindications include:
- increased sensitivity to the components of the drug;
- severe pathology of the liver and kidneys;
- malignant tumors during therapy or cured in the past;
- intolerance to the main substance.
It is also not recommended to prescribe the drug together with drugs that accelerate the functioning of liver enzymes. In this case, the effect of Duphaston will be reduced due to its rapid processing and removal from the body.
You should stop taking the drug while breastfeeding. The components of the medicine are absorbed into breast milk and passed on to the baby, which can negatively affect his health. Duphaston is also not taken together with similar hormonal drugs.
Side effects and possible consequences
Duphaston is a substitute for a natural hormone, the content of which is natural in a woman’s body (for more details, see the article: Duphaston: how to take a natural hormone substitute?). In this regard, side effects when taking the medicine are rare. These include:
- headache;
- weakness and dizziness;
- nausea;
- diarrhea;
- skin rashes;
- stomach ache;
- increasing the rate of destruction of red blood cells;
- high sensitivity of the mammary glands;
- deterioration of liver function;
- swelling;
- uterine bleeding, disappearing after increasing the dose of the drug.
Some women noted that with long-term use of the drug, there is a tendency to significant weight gain. However, experts were unable to establish a connection between the effect of the drug and the woman’s weight change.
No cases of overdose were identified. When taking a large dose of the drug, gastric lavage is performed and symptomatic therapy is carried out. It is recommended to stop taking the medicine if tumors are detected, so as not to provoke their growth.
The most dangerous is abrupt withdrawal of the drug Duphaston. Completion of the course should occur gradually. The body needs to be given time to adjust to the independent production of progesterone. If a woman stops drinking Duphaston herself, the following may happen:
- miscarriage or spontaneous birth;
- placental abruption;
- hormonal imbalance.
How long does it take to stop treatment?
Until 12 weeks of pregnancy, the corpus luteum fully performs the function of providing the body with progesterone. Starting from the 12th week, the placenta forms and takes on the task of producing the hormone. However, the complete process of placenta formation can be completed by 16 weeks, and it will be fully strengthened by 20 weeks.
In this regard, the official instructions recommend stopping taking Duphaston after the process of placenta formation is complete, namely at 20 weeks. Doctors make a decision based on the diagnosis and condition of the patient.
Before 12 weeks of pregnancy, discontinuation of the drug is highly undesirable. As a rule, Duphaston intake begins to be reduced from the 16th week. However, if there is a threat of miscarriage, the medication is extended until the symptoms that pose a risk to pregnancy have passed.
If a woman has experienced miscarriages and premature births in the past due to a lack of progesterone, then the withdrawal of Duphaston may be postponed to a later date. Sometimes it is necessary to take the drug until the last weeks of the 3rd trimester. When discontinuing Duphaston, a woman is tested for progesterone concentration before completion of therapy, during the withdrawal period and after the end of treatment.
Why do pregnant women need Duphaston?
Pregnancy may not occur for many reasons, and one of them is insufficient production of the hormone progesterone in the body. It is he who is responsible for monthly preparation for possible conception:
- Ensures and maintains the growth of the endometrium to the required level at which implantation of a fertilized egg occurs
- Rebuilds the functioning of the mammary glands, prepares them for milk production
- Stimulates uterine growth
- It prevents contraction of the uterine muscles, which helps the body perceive the embryo as “its own” and prevents its rejection.
Therefore, Duphaston is actively prescribed to women planning motherhood.
With the onset of pregnancy, the amount of progesterone in a healthy body should increase sharply. But today women most often suffer from a lack of it, especially if they have undergone the IVF procedure.
With insufficient hormone levels, the risk of fetal loss increases significantly. To prevent this from happening, a course of Duphaston is prescribed during pregnancy, which becomes an additional “supplier” of the female hormone.
The drug is prescribed until week 12, after which it must be discontinued. But in fact, practicing doctors do not recommend doing this, especially before the expiration date. During this period, the corpus luteum is responsible for the synthesis of progesterone, and after the 12th week the placenta takes over the process.
Therefore, some doctors consider it possible to cancel at this time. But the developers advise taking the product until week 20. This is explained by the fact that the placenta is fully formed only by the 16th week, after which it begins to control the process of gestation. Moreover, in very difficult cases (threatened abortion, recurrent miscarriage), taking the medicine is allowed until the adverse symptoms completely disappear.
Therefore, when and how to stop Duphaston during pregnancy should always be determined by a doctor who knows all the nuances of his patient’s health. But if a woman herself decides to stop taking the drug and gives it up in one day, then abrupt withdrawal may result in a miscarriage.
Treatment cancellation plan
The drug withdrawal regimen depends on the reason that led to its prescription, dosages during therapy, duration of treatment and the condition of the pregnant woman after taking the drug. Duphaston is withdrawn gradually. The dose and frequency of administration are reduced daily. The regimen is prescribed individually according to the decision of the attending physician. Below are sample drug withdrawal plans for various situations:
- With several miscarriages in previous pregnancies and after artificial insemination. In classical treatment, 2 tablets per day are prescribed, taken at different intervals. Weaning begins at 16–20 weeks. First, the intake is reduced to 1 tablet per day over the next 7 days. Then, for 3 days, reduce the dosage by another half tablet. At the final stage, drink ¼ of the tablet for another 3 days.
- If there is a threat of miscarriage. To maintain pregnancy, it is usually prescribed to take 1 tablet every 8 hours. After the disappearance of alarming symptoms, the dose is reduced to 2 tablets per day until the 18th week. Subsequent withdrawal of Duphaston is carried out according to the scheme described above.
- After a spontaneous abortion. If the pregnancy could not be maintained, then abruptly quitting the course of Duphaston is also impossible. Hormone therapy must be completed gradually. The duration of completion of the course depends on the schemes that were used previously. For example, if the dosage was 3 tablets, then on the first day of withdrawal, take 2, the next day - 1, then reduce to 0.5, and on the last day of use, drink ¼ of the tablet.
Cancellation of Duphaston tablets
Pregnancy is a very important and responsible stage in the life of every woman. During pregnancy, withdrawal of Duphaston should also be carried out under the supervision of a doctor and with mandatory monitoring of progesterone levels in the body. Women's reproductive health is very sensitive to the effects of negative factors in the external and internal environment. In this regard, chronic stress, physical and mental stress, errors in diet and bad habits can lead to disruptions in a woman’s hormonal system.
Hormonal regulation is responsible for the successful course of pregnancy. Quite often, women experience a deficiency of the hormone progesterone, and doctors prescribe hormone replacement therapy with Duphaston. Before starting treatment, the doctor must explain how to take the drug correctly and how Duphaston is withdrawn. It is important to remember that stopping treatment on your own can lead to serious consequences for the health of the expectant mother and fetus.
Duphaston - a cure for all diseases?
Hello, dear readers of the ElenaVolzhenina.com blog. How to make the pregnancy successful and prevent miscarriage? How to tidy up the cycle? How to improve your women's health?
For this purpose, women are often prescribed the latest generation synthetic progesterone (gestagen), the drug duphaston. So often that you might even think that this drug is a panacea for all women’s ills, a cure for all diseases. I decided to write about him.
But it turned out that the result was a very large article (or a very small book), I called it “Duphaston - legends and myths.” Almost like the legends and myths of Ancient Greece.
In this article I will tell you in the form of abstracts what the mini-book is about.
Duphaston - indications for use.
In general, the official list of indications for use is quite impressive:
- Progesterone deficiency (luteal phase deficiency of the cycle).
- Endometriosis.
- Infertility caused by luteal insufficiency.
- Threatened or habitual miscarriage (with progesterone deficiency).
- Premenstrual tension syndrome (premenstrual syndrome).
- Dysmenorrhea, irregular menstrual cycle.
- Secondary amenorrhea (in complex therapy with estrogens).
- Dysfunctional uterine bleeding.
- Hormone replacement therapy.
In short, the use of duphaston is literally a breakthrough in the treatment of many obstetric and gynecological problems.
Duphaston - side effects.
Advertising descriptions say that it has virtually no side effects.
Well, maybe it causes excessive drowsiness and sometimes headaches. When using it, there may be “breakthrough” uterine bleeding, which is easily eliminated by increasing the dose. Sometimes, rarely, there may be a rash, hives, and slight swelling.
Well, that's all. The rest is so rare that it is insignificant.
The first myth about duphaston is the replenishment of progesterone deficiency in a woman’s body.
Doctors are sure that if a woman gives birth little, ovulation is often disrupted, and the corpus luteum is weak, then she needs to take synthetic progesterone.
This gives a “simulation of pregnancies”, restores the cycle, treats infertility, miscarriage, and premenstrual syndrome.
It is recommended to take the drug almost constantly. Convenient and profitable, we kill all birds with one stone.
I tell you what really happens in the book.
The second myth about duphaston is that it does not provide a contraceptive effect.
He gives, and how. If duphaston is prescribed before ovulation, it cannot take place.
Ovulation is inhibited - this is the contraceptive effect. This may not happen immediately, but the suppressive effect of synthetic progesterone accumulates and adds up.
When small doses of progesterone, cycle after cycle, slightly “slow down” the pituitary gland, eventually ovulation stops. It may not happen right away, but it happens. As with hormonal contraceptives, ovulation stops and the reproductive system is suppressed.
In addition to this action, synthetic progestin affects the cervical secretion and the condition of the endometrium, in this its action is similar to the action of progesterone hormonal contraceptives (mini-pills). A woman ovulates for some time, and there may be pregnancies, which means early abortions.
The third myth about duphaston is that it preserves pregnancy.
What does your own progesterone do for a child?
First, and probably most importantly, it increases your basal body temperature (BBT). This gives the baby the warmth that is so necessary for his development. That is why, if BBT is lower than necessary, it is necessary to maintain the functioning of the corpus luteum.
Doctors, without hesitation, prescribe duphaston for this purpose. They say that the drug will support the corpus luteum and the child. Often these appointments occur “at random”, without indications, without diagnosis. And women themselves usually do not monitor and do not know what their basal body temperature is and whether there is a real threat of miscarriage.
How does duphaston work during pregnancy?
According to the official version, it reduces the contractile activity of the uterus and supports the function of the corpus luteum. Whether the drug supports the function of the corpus luteum, and what its use during pregnancy leads to, I tell you in great detail in my mini-book.
The fourth myth about duphaston is that its effect on the fetus is only positive.
All official sources unanimously say that duphaston does not have a negative effect on the fetus. Only positive things.
Let me not believe it. Any hormone introduced from the outside, and even in the early stages of development, necessarily interferes with the construction of the child’s organs and tissues. Sex hormones necessarily influence the formation of the reproductive and endocrine system of the fetus.
We just don’t see it yet – not enough time has passed yet. There are no studies confirming the safety of hormonal medications used during pregnancy. Therefore, if a drug is “not prohibited” due to insufficient data on its effects, this does not mean at all that it is safe.
In many countries where duphaston has been used longer than in our country, its use is considered undesirable.
The fifth myth about duphaston is that it normalizes the menstrual cycle.
For irregular cycles, the doctor will prescribe a progestin to induce “menstruation.” It is believed that this is a way to normalize the cycle. The next bleeding has passed, which means everything is in order.
Here we are faced with a total ignorance of what menstruation and the menstrual cycle are. I talked about this in detail in the video tutorial.
After taking duphaston, bleeding is sure to occur. And the woman calms down, she believes that her cycle is fine. It eliminates the symptom, the absence of bleeding, and can cause a serious disorder in the hormonal regulation of the cycle.
Therefore, “inducing menstruation with duphaston” is not at all the same thing as “establishing the menstrual cycle.” This is important to understand when you decide whether to take the drug for menstrual irregularities.
A special topic is the treatment of infertility with duphaston.
To get pregnant, your doctor recommends taking the drug in different forms for about 6 menstrual cycles. It is understood that after this the cycle is restored and pregnancy will occur easily.
Most often this does not happen. I know many women who, after such “treatment,” could not get pregnant for years.
This is understandable - your own ovulation mechanism is disrupted, and it takes time to restore it.
Are hormones really the only solution?
Often a woman, when she comes to the doctor, finds herself in a situation without a choice. She is prescribed a hormonal drug and its benefits are very authoritatively explained.
In such a situation, it is important to ask questions. What are you prescribed and why? How does the drug work? Is it often prescribed? In which cases? What complications? You can google it on the Internet and read descriptions of the drugs.
Please read carefully. For example, “the absence of a thermogenic effect” for duphaston is not written everywhere. But in reality, this “absence” means that the drug does not increase the basal body temperature, which the baby so needs for normal development. But he suppresses the work of his yellow body.
So we have to think: did the child survive thanks to this “preservation”, or in spite of it? How many miscarriages have occurred on duphaston? Where can I find these statistics?
In fact, everything is written, nothing is hidden - it is important to see it. Don't take anything for granted, learn to read between the lines. Be picky and meticulous, because we are talking about your health and the health of your child.
The doctor will prescribe a drug, for him you are one of many, tomorrow he will not remember your face. And you will remain with your child for the rest of your life, and there will be no one to present the bill to, because no one is personally responsible for you.
In an emergency situation, it is difficult to maintain prudence and a sober outlook. It is difficult to find the right way out when you are scared for your child, but the doctor authoritatively recommends something.
In order to avoid getting into such situations in principle, it is necessary to prepare in advance for the birth of a child.
This is where the Sympto-Thermal Fertility Recognition Method (STMRP) comes to your aid. If you started self-observation in advance, then you will know exactly the state of your cycle, the quality of the corpus luteum, the date of conception, and whether or not there is a threat of miscarriage.
You'll have an objective method so you can remain confident and know exactly what's going on. If even before pregnancy you discovered a deficiency of the corpus luteum, then you have the time and opportunity to correct it.
Establish a diet with a predominance of yellow-red foods, they restore the luteal phase. Relax, reduce stress, improve relationships. Maybe conduct a course of wellness measures, use the possibilities of homeopathy, reflexology, osteopathy, psychology. Sign up for a swimming pool, go to the sea. All in your hands.
The birth of a child happens once or twice in a woman’s life, rarely more. Therefore, it is worth preparing for this event without relying on hormonal drugs and the competence of the local gynecologist.
I wish you health without synthetic hormones! Sincerely, Elena Volzhenina.
Why is the drug prescribed to pregnant women?
There are clear indications for prescribing Duphaston:
- recurrent miscarriage (the woman has a history of several miscarriages);
- dysmenorrhea;
- endometriosis;
- risk of miscarriage.
Before prescribing Duphaston, the gynecologist must conduct a comprehensive examination of the woman’s body. If a woman cannot become pregnant for a long time or several previous pregnancies ended in spontaneous abortions, then treatment should be carried out for 3-6 cycles before the expected conception. Duphaston is also used in women with signs of miscarriage in early pregnancy.
You need to take the pills according to special regimens, which your doctor can adjust depending on the specific clinical situation.
Main characteristics of the drug
Duphaston is available in tablet form and is well absorbed from the gastrointestinal tract. This form of release is very convenient for pregnant women. One tablet contains 10 mg of dydrogesterone. This synthetic substance, unlike natural progesterone, does not cause side effects such as:
- headache;
- weakness, sleep disturbance;
- nausea;
- sudden mood swings.
Duphaston does not have a masculinizing effect (there is no deepening of the voice, excess hair on the body and face), and does not affect weight or the amount of body fat. This hormonal drug is effective and safe for both the woman and the fetus. However, during pregnancy, the drug should be discontinued with great caution and only under the supervision of the attending physician. Sudden withdrawal of the drug can lead to unpleasant consequences for the health of the woman and the fetus.
How to stop the drug
The Duphaston withdrawal regimen is determined individually for each individual woman and depends primarily on the level of progesterone in the body, as well as on the indications for prescribing the drug. Discontinuation of this hormonal drug should be carried out by a qualified specialist with experience in caring for patients taking Duphaston.
The drug should be stopped when the level of progesterone in the body has returned to normal or the woman experiences unwanted side reactions to the drug. Cancellation should begin gradually, slightly reducing the dosage of the drug. As a rule, the reason for stopping Duphaston during pregnancy is the 20th week. If you took 4 tablets a day, then every day their number needs to be reduced by one, therefore, stopping the drug takes about 4 days.
The time of drug withdrawal may vary depending on the condition of the pregnant woman and the initial dosage of Duphaston. Considering the large number of factors that influence the process of stopping therapy, it is not possible to unequivocally answer the question of how to stop Duphaston. In order not to risk your health and the health of your unborn baby, it is better to consult a specialist whom you can completely trust.
Abruptly stopping Duphaston is considered dangerous and can lead to serious complications.
How to use?
Of course, not all expectant mothers need to take the drug during the gestation period. The drug is prescribed if indicated (history of miscarriages) and after a series of tests. It is strictly forbidden to take the drug “just in case” on the advice of friends, either immediately after the delay or during the first weeks. Only a doctor can recommend use!
The decision to take the drug yourself can have unpredictable consequences. Pregnancy is not the time to experiment with your health. Even one day of taking a hormonal drug without a prescription can cause a malfunction in the body.
Therefore, it is worth repeating once again: Duphaston is strictly forbidden to be taken during planning, immediately after a delay, or during pregnancy, if the drug is not recommended for use by a doctor!
To achieve a positive result, you need to know exactly what day of the cycle you need to start taking the pills, how many weeks you should continue taking them, and how to properly reduce the dose.
The instructions cannot provide detailed answers to these questions, since they provide a standard treatment regimen. And to obtain a positive result, Duphaston is prescribed individually, taking into account the characteristics of the patient’s body.
Let's figure out what the instructions say about taking the drug during preparation for pregnancy and after its onset.
Planning
To begin with, let’s figure out why and why the drug is prescribed. It is recommended for use in the following cases:
- infertility in case of insufficient progesterone production;
- dysmenorrhea;
The standard dosage depends on the type of disease:
- for endometriosis, you need to take a tablet containing 10 mg of a synthetic hormone three times a day. You need to take the drug at a certain time, from the fifth to the twenty-fifth day of the cycle;
- for infertility due to insufficient progesterone synthesis: 1 tablet no more than once a day from the fourteenth to the twenty-fifth day of the cycle.
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If pregnancy occurs during treatment, you should under no circumstances stop taking the pills. In most cases, Duphaston is not canceled in the early stages of pregnancy. Why do you need to continue treatment?
Abruptly stopping the medication will cause a surge in hormone levels, and such actions can lead to pregnancy failure. How long should you take the drug during pregnancy? Only a doctor can answer this question. In some cases, you have to continue taking it until 36 weeks.
But often the drug is discontinued earlier. How many weeks you need to continue treatment depends on the individual reactions of the body. If you stop the drug correctly, pregnancy after stopping Duphaston will proceed normally. You need to take the drug strictly according to the schedule, trying not to miss the dosage time. What to do if your appointment time is missed? In this case:
- if no more than 6 hours have passed since the time of administration, take the tablet, then drink the drug according to the prescribed regimen;
- if more than 6 hours have passed, skip the dose and do not take an additional dose.
Pregnancy
Why can an appointment be scheduled during pregnancy? The drug is prescribed if the following indications exist:
- with habitual miscarriage;
- with threatening spontaneous abortion;
- during pregnancy occurring against the background of endometriosis or endometritis.
How to recognize the threat of spontaneous abortion? The main symptoms of threatened spontaneous abortion:
- nagging pain radiating to the groin or lower back. The pain becomes more intense when moving and subsides a little if you lie down;
- bloody discharge from the genital tract. The discharge does not have to be significant; spotting is no less dangerous. Please note that discharge may appear periodically, that is, if it has stopped, this does not mean that the threat has passed.
It should be noted that spotting brown discharge is not always a threat of interruption. Sometimes they appear at the moment when the fertilized egg implants in the uterus. But such symptoms cannot be ignored; it is worth visiting a gynecologist to find out the reasons.
But if the discharge is bright red, then you need to urgently call an ambulance. Duphaston for this condition is prescribed by a gynecologist. Improper use of the drug may aggravate the situation and the child will not be saved. Standard scheme:
- initially – 4 tablets once, then 1 tablet three times a day;
- it is important that the interval between doses is the same and is about 8 hours (provided that the standard dosage is prescribed, one tablet three times a day).
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The duration of the course depends on the condition of the pregnant woman; if the threat of interruption has disappeared, the doctor decides to stop treatment. Moreover, you need to gradually reduce the dose; the following scheme can be used:
- one tablet twice a day for a week;
- over the next week, the daily dosage is halved, that is, once a day is enough;
- then they begin to take the drug every other day for another week.
It is very important to reduce the dosage gradually, since with abrupt withdrawal you can expect the development of a repeated threat of miscarriage. On average, the withdrawal time during which you need to reduce the dosage of the hormone is about three weeks.
How to stop Duphaston during pregnancy: features of use, the dangers of refusal and withdrawal plan
The development of the fetus during pregnancy is influenced by a large number of different factors. Therefore, it is important to protect it, first of all, from processes that can cause premature birth or miscarriage. In the early stages of pregnancy, the body needs the hormone progesterone; due to its deficiency, various disorders occur and pathologies arise. It is important to replenish its supply; for this, various medications are used, for example, Duphaston. However, there comes a period when you can stop taking it, but many girls do not know how to stop Duphaston during pregnancy.
How to correctly stop using the drug duphaston during pregnancy
A modern woman is concerned about many important issues during pregnancy. One of them is about how to stop Duphaston during pregnancy. This concerns many people, because this drug is now very often prescribed to women who are pregnant or planning a pregnancy.
1 area of use
Duphaston is a completely synthetic drug. It is an analogue of the natural female hormone progesterone and successfully replaces it in the body. And progesterone, in turn, is the most necessary hormone for conception and the successful development of the fetus. It is produced by a woman’s ovaries, and on ordinary days its concentration is not very high. It increases in the 2nd half of the menstrual cycle, when a mature egg leaves the ovary.
It is progesterone that maintains the normal function of the endometrium of the uterus so that the fertilized cell can successfully attach to the wall and begin to develop. If this does not happen, then after the onset of menstruation the concentration of the hormone decreases. When pregnancy occurs, on the contrary, more and more progesterone is produced. It is he who helps the fetus develop, supports its nutritional processes, and keeps the uterus in the right tone, preventing it from contracting.
It is quite clear that a lack of this hormone in a woman’s body can not only negatively affect the course and outcome of pregnancy, but pregnancy itself may not occur.
The reasons for the lack of progesterone are different, and it is individual for each woman. Only a doctor can determine the required concentration by prescribing the appropriate tests. And only a doctor can determine the need to use drugs such as Duphaston.
The instructions for this drug indicate that it cannot harm the health of the woman and the unborn child, that it
Source
In what cases is the drug prescribed?
There are certain symptoms that cause the drug to be prescribed, these include:
- endometriosis;
- past pregnancies ended in miscarriage;
- dysmenorrhea;
- the presence of symptoms indicating the likelihood of abortion.
You can start taking the medicine only after a thorough study. First, you need to determine whether the woman has an individual intolerance to the components of the drug.
Features of the drug
The drug is available in tablet form and is easily absorbed by the digestive system. The main component is dydrogesterone, about 10 mg in one tablet. This substance is of artificial origin and differs from natural progesterone in the absence of the following side effects:
- headache;
- nausea;
- sleep problems;
- general malaise of the body;
- weaknesses.
The big advantage of the drug is the absence of a masculinizing effect, in which there is an increase in muscle mass, a rough voice, an increase in hair, etc. Numerous studies have shown the complete safety of the drug for both mother and child. However, it is important to systematically check changes in the body using medical diagnostics; when improvements are noticeable, the specialist will prescribe Duphaston withdrawal regimens.
Do I need to consult a doctor before stopping?
Experts prescribe Duphaston for women who, as a result of examinations, have discovered disorders, to be more precise - insufficient synthesis of progesterone. This process is directed by the corpus luteum, but many experience early dysfunction of this gland. To cope with this problem, it is necessary to replenish progesterone reserves artificially. It is for these purposes that Duphaston is prescribed; the effect of the medication has a positive effect on the course of pregnancy.
Basically, the attending physician prescribes the drug until the 20th week of fetal development. Although the instructions for the drug indicate that the duration of use is the same as the time until the threat of miscarriage disappears. Therefore, after 20 weeks of pregnancy, the specialist again prescribes diagnostics, if the result shows a positive result, then the doctor will tell you how to stop Duphaston during pregnancy so as not to harm your health. Otherwise, the reception continues until the end of signs of inclination towards an induced abortion.
Experienced gynecologists know that it is impossible to immediately cancel Duphaston after the symptoms of the disorder disappear, especially before 12 weeks. This is due to the high likelihood of relapses.
It is strictly forbidden to stop taking the drug on your own! There are cases where this has caused serious consequences. This is dangerous to do, because only doctors know how to stop Duphaston.
How to cancel duphaston during pregnancy
Discussion of how to properly stop duphaston during pregnancy. Taper Scheme
Preparations that are analogues of progesterone are used in obstetric practice when there is a threat of spontaneous abortion and to prevent recurrent miscarriage.
According to the results of numerous pharmacological and medical studies, the best progesterone drug is Duphaston .
The drug is prescribed from the first day of determining pregnancy to women with recurrent miscarriage and pregnant women after the IVF procedure. In other cases, the use of Duphaston is necessary when there is a threat of spontaneous abortion caused by a lack of progesterone.
Duphaston is prescribed to pregnant women from the first weeks of pregnancy if there is a lack of production of the hormone progesterone. From the beginning of pregnancy, this function is performed by the corpus luteum of the ovaries. However, many women, especially those pregnant through IVF, experience insufficiency of the luteal phase (hypofunction of the corpus luteum). In this case, artificial supply of progesterone from the outside is necessary for the normal development of pregnancy.
Gynecologists prescribe Duphaston until 16–20 weeks of pregnancy. The official instructions for the drug state that in case of threatened abortion, treatment is carried out until the symptoms completely disappear, then the dose is constantly reduced.
However, guided by practice, experts do not recommend discontinuing Duphaston after symptoms disappear, especially before the 12th week of pregnancy, as the risk of relapses increases.
pulls the back during pregnancy in the early stages of 5 weeks Pain in the left side of the abdomen at different stages of pregnancy can be associated not only directly with the pregnancy itself, but also with diseases of the internal organs that the woman had before or appeared during pregnancy
Until 12 weeks of pregnancy, progesterone synthesis belongs to the corpus luteum, then the placenta assumes this role. Therefore, some experts believe that Duphaston should be discontinued
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from pregnancy to childbirth
When is it appropriate to cancel an appointment?
The synthesis of progesterone by the corpus luteum continues until the 3rd month of pregnancy, then the placenta takes on this role. For this reason, some experts believe that it is at this time that Duphaston should be discontinued.
In the instructions for the drug you can find a recommendation from the manufacturer, which states that use should be continued until the 5th month of gestation. This is due to the fact that the formation of the placenta presumably ends at 4 months, after which the feto-placental complex functions normally.
After the examination, the obstetrician-gynecologist must explain to the patient which Duphaston withdrawal regimens to use during pregnancy. Typically, the course of treatment ends at a maximum of the 20th week, although if a woman has had a miscarriage in the past or has become pregnant through IVF (in vitro fertilization is a procedure that allows a woman to become pregnant in case of infertility), then the use of the medicine continues after the 20th week .
How is Duphaston discontinued?
It is important not only to use the drug correctly, but also to wean yourself from its use. This should be done slowly and carefully, under the strict supervision of a doctor. The specialist prescribes the withdrawal of Duphaston during pregnancy according to the scheme; this is the most rational and safe option.
The drug is taken up to 12-20 weeks, 2 tablets/24 hours, that is, one tablet every 12 hours. When pregnancy reaches 20 weeks, the course of administration should be reduced to 1 tablet/24 hours. Although the effectiveness will be higher if you take half a tablet within 12 hours. That is, the scheme for discontinuing Duphaston during pregnancy can be characterized as follows: after diagnosis, which showed that the pregnancy is proceeding normally, you can reduce the intake of tablets by half, from the amount that was initially prescribed. In other words, if a specialist has prescribed 1 tablet per day, then if you refuse, the dose is reduced by half, that is, 0.5 tablets for 24 hours.
Cancellation of Duphaston during pregnancy is an important process that requires maximum effort from every girl. This is due to the fact that the medication cannot be stopped even for one day. Otherwise, there is a high probability of complications that will threaten the baby’s health.
Cancellation of duphaston during pregnancy
How exactly to cancel Duphaston? One of them is about how to stop Duphaston during pregnancy. In addition, Duphaston is prescribed during pregnancy if a woman suffers from chronic endometritis. I had a frozen pregnancy and a miscarriage while taking duphaston. Therefore, Duphaston during pregnancy should be taken and discontinued only as prescribed and under the supervision of an experienced gynecologist.
I took this duphaston almost until 34 weeks. I was carrying my precious twins, playing it safe. My personal opinion is that duphaston will not harm you, the pregnancy hormone will not be superfluous to you, especially if something went wrong during the withdrawal, I would not risk it.
Cancellation of duphaston during pregnancy
I didn’t take a single tablet for headaches without my doctor’s permission during pregnancy. From the beginning of pregnancy I took 2 tablets, from 17 weeks - 2, from 19 - 1, until 20 weeks, tomorrow is the last tablet!
At week 5, I was prescribed Duphaston in a dosage of 1 tablet morning and evening. At 9 weeks they told me to cancel. The withdrawal plan is as follows: drink the same for another week, then drink only once a day for a week and stop.
Or maybe it’s because I got pregnant by accident, and before that I couldn’t specifically take Duphaston and Progynova. I generally have a very good doctor, I trust her.
This is a paid doctor, an appointment with her takes 2 weeks in advance, and there are long queues. And according to the last ultrasound at 9 weeks, everything was fine. Duphaston is an excellent support for pregnancy in the early stages, it gives you the hormone progesterone, which may be low in the body, which causes abdominal pain. Not always, but there is a risk. I’ve been in the hospital for 4 weeks now and I’ve told so many things... Because of inexperienced doctors, girls lost children. It generally says to take 2 tablets for 20 weeks and only then reduce it.
Google and read standard withdrawal plans. 20 weeks, 3 tablets a day, but I had severe cramps
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