pharmachologic effect
The active component of the drug, dydrogesterone, is an analogue of natural progesterone . Duphaston is a hormonal drug.
Under the influence of this medicine, thermogenesis is not disrupted in a woman’s body, so basal temperature can be measured to determine ovulation. The product does not affect metabolic processes in the body or liver function. Dydrogesterone is very similar in properties and structure to natural progesterone. However, the drug does not provoke the side effects that occur when taking a number of synthetic progesterones. Wikipedia indicates that this drug does not have androgenic, estrogenic, anabolic, thermogenic, or corticoid effects. As a component of hormone replacement therapy for menopause , the drug provides a positive effect of estrogens on the lipid profile blood . But if estrogens have a negative effect on the blood coagulation process, then dydrogesterone has no effect on coagulation.
When taken orally, there is a selective effect of dydrogesterone on the endometrium , which helps prevent the high risk of hyperplasia or carcinogenesis, provoked by increased production of estrogen. The medicine does not have a contraceptive effect. During treatment, the drug does not affect ovulation. Menstruation also continues as usual when taking the medication. A woman can become pregnant with dydrogesterone and maintain pregnancy during treatment with the drug, since no negative effect on the fetus is noted during the treatment process. There is a selective effect on progestin receptors of the uterine mucosa. It does not affect the ovulation of the follicle. There is no masculinizing or virilizing effect.
Since the natural hormone dydrogesterone reduces the level of excitability of the myometrium, under its influence the contractile activity of the uterus decreases. The answer to the question of whether this drug affects weight is clear: taking Duphaston does not contribute to gaining extra pounds.
Thus, dydrogesterone reduces the effect of natural estrogens on the body, therefore it is successfully used for infertility , PMS, recurrent miscarriage, menopause , in women who have already had a frozen pregnancy , etc.
Benefits of the medicine
It is not for nothing that obstetricians and gynecologists choose this drug. The drug not only compensates for the lack of pregnancy hormone in the body of the expectant mother, but is absolutely safe for her and the fetus. This medicine reduces muscle contractions of the uterus. Experts call the condition hypertonicity, and it is also dangerous for women because it can lead to self-abortion in the early stages of pregnancy. Duphaston prevents this risk. Moreover, it does not affect blood pressure, blood clotting, or liver function.
The drug promotes the formation of a healthy uterine mucosa. Obstetricians and gynecologists also prescribe the drug to pregnant women in cases of chronic endometritis. This gynecological disease is characterized by high activity of the immune system, which perceives the fetus as a foreign body. For this reason, it is expelled from the woman’s body. Duphaston is an excellent corrector for this condition, because it produces blockers that normalize the functioning of the immune system. And in this way, an obstacle to miscarriage in early pregnancy is also created.
Pharmacokinetics and pharmacodynamics
After oral administration, dydrogesterone is rapidly absorbed from the gastrointestinal tract; after 2 hours the highest concentration of the active component in the blood is observed. The degree of binding to blood proteins is 97%. 56-79% is excreted from the body by the kidneys; a day after administration, about 85% is excreted from the body; the entire excretion process is completely completed after 72 hours. Metabolites are present in urine , mainly in the form of glucuronic acid conjugates .
There is no data on changes in the pharmacokinetics and pharmacodynamics of the active component in people who suffer from kidney disease. Does not accumulate.
Indications for use
Why Duphaston tablets are prescribed depends on the diagnosis and treatment regimen determined by the doctor.
Currently, the following indications for use of the drug are determined:
- Insufficiency of progesterone in the body (in case of infertility associated with insufficiency of the luteal phase, with the threat of miscarriage or habitual loss of the fetus, with dysmenorrhea , menstrual cycle disorders, amenorrhea of secondary origin).
- As part of hormone replacement therapy (during menopause, it is used to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens; during surgical castration).
Thus, tablets are prescribed for dysfunctional uterine bleeding, for polycystic ovary syndrome , for corpus luteum cyst, for endometritis, for uterine fibroids .
What else the medicine is prescribed for, when it is prescribed, and what the dosage should be, you should ask your doctor.
How to use
Dydrogesterone is “ pregnancy hormone ” and is therefore safe for the fetus. But this is not a reason to take the drug without a doctor's prescription . Remember that any hormone, one way or another, will “manifest” in the future .
If a woman has a natural pregnancy, she feels great, all changes occur according to the fetal development schedule, then prescribing Duphaston only for “reinsurance” is unacceptable ! If you feel that your doctor is incompetent, contact another specialist, or better yet two, and compare their verdicts!
The dosage schedule and dosage of Duphaston depend on the specific situation : the duration of pregnancy, the mother’s well-being, the presence of bleeding, the threat of pregnancy failure, etc. Only an experienced specialist can prescribe a course of treatment!
Contraindications
There are contraindications for taking Duphaston.
First of all, you should not take pills if you are highly sensitive to dydrogesterone or other components of the drug, as this can harm the woman’s body.
The tablets should be prescribed with caution to women who have suffered from itching during pregnancy before.
There is no data on the negative effects of dydrogesterone on people who suffer from chronic renal failure
When is Duphaston prescribed?
This medication is a source of the synthetic hormone dydrogesterone. It is he who is an analogue of the well-known progesterone and, in fact, performs the functions assigned to it. In addition to dydrogesterone itself, this medicine also contains certain auxiliary substances, namely: colloidal silicon dioxide, corn starch, lactose monohydrate and others.
The drug can be prescribed both during pregnancy and at the planning stage. If a woman cannot become pregnant naturally for a long time, the reason most likely lies in the unpreparedness of the muscular layer of the uterus, or endometrium, to receive a fertilized egg, as a result of which it cannot reliably attach and leaves the female body.
In such a situation, taking Duphaston for several months helps prepare the endometrium and contributes to a successful pregnancy. In addition, after the fertilized egg attaches to the walls of the uterus, this drug also helps the ovaries maintain the required level of progesterone in the body of the expectant mother.
As a rule, this drug is prescribed to the fair sex even before pregnancy or in its earliest stages, when the likelihood of miscarriage is highest. After 20 weeks, the placenta, in most cases, successfully copes with maintaining a sufficient level of progesterone in the blood of the expectant mother, so this appointment is usually canceled.
Side effects of Duphaston
During the reception process, some side effects of Duphaston may be observed:
- immune system: hypersensitivity (very rare);
- hematopoietic system: hemolytic anemia (isolated cases);
- nervous system: migraine , headache ;
- hepatobiliary system: minor liver dysfunction, which may cause weakness, jaundice, abdominal pain;
- reproductive system : breakthrough bleeding during administration (rare), prevented by increasing the dosage of the drug; the sensitivity of the mammary glands may increase;
- subcutaneous tissue, skin: itching, urticaria (rare), Quincke's edema (very rare);
- general disorders: peripheral edema (very rare).
If any of the above symptoms occur, you should tell your doctor that this side effect is occurring.
Instructions for use of Duphaston (Method and dosage)
The drug is prescribed according to an individual regimen, both when planning pregnancy and for gynecological diseases. It doesn’t matter how you take it, before or after meals.
Duphaston tablets, instructions for use
The indicated dosage regimens are indicative only. To prescribe a treatment regimen and determine how long the pills can be taken, the doctor must take into account the symptoms of the disease and the phases of the monthly cycle. The daily dose of the medicine should be divided into 2-3 doses, tablets should be taken at equal intervals.
Duphaston for endometriosis is prescribed in a dose of 10 mg of dydrogesterone 2 or 3 times a day. How to take Duphaston for endometriosis depends on the doctor's prescription. You need to take the product from days 5 to 25 of the cycle or do it without a break. It should be borne in mind that only the attending physician can prescribe Duphaston for endometriosis. Reviews from doctors on the Internet or any medical forum with information about treatment should be taken only as information for reference.
Duphaston for conception in case of infertility of progesterone origin is prescribed from the 11th to the 25th day of the monthly cycle. You should definitely find out from a specialist how to take Duphaston for conception. As a rule, treatment lasts for 3-6 months. How to take Duphaston to get pregnant, how much you need to drink to get pregnant, depends on the woman’s diagnosis and the individual characteristics of her body.
If there is a delay after taking the pills and other signs of pregnancy while taking the drug, treatment should continue, and the dose should be equal to that prescribed for a habitual pregnancy loss.
If a woman has a threatened miscarriage or recurrent pregnancy loss , it is advisable to use the medicine only if there is clear evidence of endogenous progesterone deficiency. Women with threatened abortion are advised to take a single dose of 40 mg of dydrogesterone, followed by 10 mg every 8 hours for a week. Then the dose is gradually reduced. But if the threat of miscarriage arises again, the dose is increased. Application can be practiced until the 20th week of pregnancy. But more precisely, your doctor will advise you individually about which week to take the pills during pregnancy.
How to take if there is a threat of miscarriage in the early stages , the doctor determines individually. As a rule, in case of recurrent miscarriage at the stage of pregnancy planning, Duphaston is taken from the 11th to 25th day of the cycle, provided that conception has occurred, the woman continues to receive the same dose. Further, after the 20th week of pregnancy, the dose should be gradually reduced.
Women suffering from PMS are prescribed 10 mg tablets from days 11 to 25, treatment lasts from 3 to 6 months.
Duphaston for delayed menstruation , irregular cycles and other menstrual disorders is prescribed from cycles 11 to 25, 2 times a day, 20 mg. How to induce menstruation with Duphaston depends on the woman’s diagnosis. The doctor prescribes the drug for irregular cycles, determines how to take Duphaston to induce menstruation, how much to drink to induce menstruation. Whether it is possible to induce menstruation with amenorrhea depends on the correct treatment. As a rule, taking Duphaston in this case is combined with taking estrogen . This treatment should be practiced for at least three monthly cycles.
In case of dysfunctional bleeding, the drug is prescribed 10 mg twice a day for 5-7 days, combining the dose with 0.05 mg ethinyl estradiol . In order to prevent the development of bleeding, tablets are prescribed at a dose of 10 mg in the period from 11 to 25 days of menstruation. The dose is combined with 0.05 mg of ethinyl estradiol (1 time per day).
If hormone replacement therapy , it is used in combination with estrogens. Continuous treatment involves taking 10 mg of the drug for 14 days during each monthly cycle. If necessary, the dose can be increased to 20 mg per day.
How to take Duphaston for endometrial hyperplasia depends on what other drugs the doctor prescribes for treatment. As a rule, treatment of endometrial hyperplasia involves taking the drug at a dose of 10 mg from days 16 to 25 of the cycle.
How to take Duphaston for an ovarian cyst also depends on the specialist’s prescription. For ovarian cysts, treatment should continue for at least 3 months.
Treatment of follicular ovarian cyst involves prescribing 10 mg of the drug 2 times a day. ovarian dysfunction is being treated , as well as if multifollicular ovaries .
If a woman misses a Duphaston tablet, then an additional dose should not be taken. You need to continue taking it with the next tablet. For convenience, you can count how many tablets are left in the Duphaston package and monitor the regularity of taking it.
For any diagnosis, you should not start drinking Duphaston without a doctor’s prescription.
The feasibility of using Duphaston in the early and late stages of gestation
Progesterone is extremely important when carrying a child; it is not without reason that it is also called the “pregnancy hormone”. At the initial stage, it helps the embryo to securely attach itself, since it reduces the contractile movements of the uterus. In the future, due to its property of relaxing muscles, the hormone maintains pregnancy. It is also important for the formation of a full-fledged uterine mucosa: it must have enough vessels that nourish the unborn baby.
Progesterone also plays a role in awakening the maternal instinct in the expectant mother. It is he who makes a woman (even a non-pregnant one) move at the sight of babies, programs her to take care of the child.
In the second half of the menstrual cycle, progesterone begins to produce the corpus luteum, which is formed after ovulation. Once a pregnancy has taken place, it continues its work until the placenta is formed. Further, the synthesis of progesterone already depends on it.
The corpus luteum begins to produce progesterone, which is necessary for the consolidation of the embryo and the further maintenance of pregnancy.
If a pregnant woman's body does not produce enough progesterone, it becomes difficult for the fetus to develop normally. The uterus, with its contractile movements, can simply push it out - in this case, a miscarriage will occur. If there is insufficient blood supply to the uterus, there is a risk of oxygen starvation of the baby (possibly partial detachment of the fertilized egg), which can lead to the fading of the pregnancy.
If a low level of progesterone is detected (using a special blood test in the laboratory), the doctor prescribes Duphaston to the pregnant woman. The drug replenishes the lack of natural hormone and eliminates these problems (in approximately 85% of cases, which indicates the good effectiveness of the drug). Basically, this situation is typical for the early stages of pregnancy: it is in the first trimester that it is most advisable to take a hormonal drug.
Hypertonicity of the uterus manifests itself in the form of nagging and aching pain below the navel, a feeling of tension in the groin (this condition is diagnosed using ultrasound). However, if a woman simply feels a tingling sensation on her sides, then this may be a natural stretching of the uterus, which is adapting to bearing a fetus. A clear symptom of an incipient miscarriage is bloody vaginal discharge (even a small amount may indicate a hormonal imbalance).
Basically, Duphaston is prescribed in the early stages to maintain pregnancy.
By the 16th week, the placenta is fully formed, which usually copes with the production of progesterone on its own. However, in some cases, Duphaston is also taken at a later stage when the tone of the uterine muscles increases: this helps to avoid premature birth.
For longer periods, Duphaston can be prescribed for increased uterine tone
As for the potential negative effect of Duphaston on the fetus, the opinion of doctors is ambiguous. Some believe that the hormonal drug is completely safe in this regard. Other doctors are not so optimistic.
Many Western doctors are shocked by the amount of synthetic progesterone consumed by Russian pregnant women. In the 70s in the USA it was often prescribed to expectant mothers in the early stages. But subsequently, research evidence emerged that it causes minor developmental defects in the fetus, especially those affecting the genitals. And the Federal Drug Administration (FDA) introduced a ban on the use of artificial hormone in the first trimester (the corresponding contraindication appeared in the instructions for the drug; by the way, it is sold in the USA only by prescription).
European doctors also conducted their own research: as a result, in a number of countries, artificial progesterone was even banned from sale. Some domestic doctors, for example, gynecologist Elena Berezovskaya, also do not approve of “preserving” progesterone therapy.
In fact, there are not many women with insufficiency of the luteal (second) phase of the cycle, and in our country doctors often misdiagnose it. Even at the planning stage, they analyze the progesterone content traditionally on the 21st day of the cycle, while the maximum level of the hormone is observed 7 days after ovulation (and for different women it can occur on different days). Thus, Duphaston is mistakenly prescribed, the use of which continues even during pregnancy. In addition, the woman becomes psychologically dependent on the drug - she is sure that without the artificial hormone her pregnancy is doomed.
Interaction
With simultaneous administration of inducers of microsomal enzymes ( Rifampicin , Phenobarbital), it is possible to accelerate the metabolism of dydrogesterone and reduce the effect.
There is no evidence of incompatibility with other drugs.
Duphaston and Proginova can be prescribed in parallel, most often when planning pregnancy. Proginova is an estrogen drug.
Duphaston and Clostilbegit are prescribed in combination for the treatment of infertility. Clostilbegit is a non-steroidal anti-estrogen that stimulates ovulation.
Borovaya uterus and Duphaston - the compatibility of these drugs is controversial. There is information that the herbal medicine boron uterus in combination with Duphaston can provoke bleeding.
special instructions
If Duphaston is used in combination with estrogens, caution must be exercised in patients suffering from vascular diseases, heart disease, kidney disease, diabetes mellitus , epilepsy , and migraine. Also carefully prescribed for liver diseases.
If a woman is prescribed a drug for the purpose of hormone replacement therapy, a series of studies must be carried out before starting, and later, regular mammographic examinations . It is important to take into account all contraindications. The doctor must clearly examine the patient's medical history. During HRT, the tolerability of such treatment should be monitored at certain intervals. There is a possibility of breakthrough bleeding in the first months of therapy. If such bleeding also occurs after a course of treatment, the woman needs to undergo an endometrial biopsy to exclude malignant processes.
Duphaston should not be taken by those who suffer from lactase deficiency, galactose deficiency or malabsorption syndrome.
Does not affect the ability to drive a car or operate precision machinery.
If you regularly experience discharge while taking pills, you should tell your doctor about it.
Since Duphaston is a synthetic progesterone , it can replace the natural hormone progesterone, for which Duphaston is prescribed to pregnant women, as well as women during pregnancy planning. How to drink Duphaston to get pregnant is determined by your attending physician. When asked whether this drug suppresses ovulation, experts answer unequivocally in the negative. How this medicine affects ovulation depends on the frequency and duration of its use.
Often women are interested in whether the drug can cause a delay in menstruation , or how to drink to induce menstruation. It should be understood that the regulation of menstruation is ensured by the production of estrogen and progesterone in the body. Often a woman notes that her period has not started if there is a lack of progesterone in the body. If the ovaries do not produce enough progesterone for any reason, a course of Duphaston is prescribed. If your period does not come after taking Duphaston, you should take a pregnancy test . Provided that there are no periods after discontinuation of the drug, and the woman is not pregnant, she should definitely consult a doctor. The reason for scanty periods after the drug may be a lack of estrogen, late ovulation, or changes in the uterus.
It should be borne in mind that when using Duphaston to induce menstruation “for convenience”, without a doctor’s prior prescription, although a woman induces menstruation, she risks disrupting the functions of the hormonal system. As a result, after uncontrolled treatment, a woman sometimes complains that she has heavy periods after taking pills or that her periods take a long time.
Therefore, the answer to the question whether Duphaston can be taken without a doctor’s prescription is clear: this should not be done.
Another question that interests women: do they get better from Duphaston? Namely, does it make you gain weight if you take it for a long time? Since the active substance of the drug is synthetic progesterone, when asked whether it makes you fat, experts answer in the negative.
Does hormonal imbalance interfere with conception?
It is not recommended to combine Duphaston at the beginning of pregnancy and throughout it with medications such as Phenobarbital and Rifampicin. Such experiments can lead to inhibition of the drug effect of the drug.
Duphaston is usually prescribed in the early stages of pregnancy, or from the planning stage of pregnancy, and its use continues from the moment of conception.
The drug is prescribed by a gynecologist, and in most cases the drug is indicated in order to maintain and safely prolong pregnancy until the time when the placenta takes over the functions of hormone synthesis.
By taking duphaston during pregnancy, the level of progesterone in the blood plasma is normalized, which contributes to the normal course of pregnancy.
Duphaston during pregnancy can also be used if there is a threat of termination, in order to prevent miscarriages during ICSI or IVF procedures, in case of previous early terminations of pregnancy or in the presence of a history of frozen pregnancy.
If the drug is used as prescribed by a doctor, the question of whether duphaston can be taken during pregnancy does not even arise - it is directly indicated.
Of course, it is better not to skip taking the drug, but given its cumulative effects, this is not critical.
If one tablet is missed (forgot, it was not possible), it is recommended to take the next dose in the next 6 hours.
If more than six hours have passed, no additional dose is required; continue taking the drug as usual.
Try not to miss taking the drug, sticking to the same time. This will allow you to maintain optimal high concentrations of the substance in the blood plasma.
The main contraindication to use is individual intolerance to the drug and allergic reactions to its use.
The drug is also not prescribed for rare Rotor and Dubin-Jones syndromes, severe liver damage, malignant tumors of the breast and reproductive organs.
The drug is prescribed very carefully for thrombophlebitis and a tendency to thrombosis.
One of the female sex hormones is progesterone; this substance plays an important role in the functioning of the reproductive system. As you know, the monthly female cycle includes two main phases - proliferative and secretory.
In the first two weeks of the cycle, the amount of progesterone is minimal, but after the release of the egg, its amount reaches its peak. Thanks to the hormone, the following changes occur in the body:
- blood supply to the uterus increases;
- the mucous layer lining the internal cavity of this organ thickens and loosens.
That is, the main function of the hormone is to prepare the body for pregnancy. If there is a lack of this substance, the fertilized egg cannot implant in the uterus and, accordingly, pregnancy does not occur.
Therefore, if difficulties arise with conception due to a lack of progesterone, Duphaston is prescribed. The drug contains a hormone analogue obtained synthetically. You will have to take the drug not for a day or two, but for at least several weeks, in some cases up to six months. Pregnancy during treatment usually occurs within 3-4 months.
When carrying out IVF against the background of infertility, Duphaston is prescribed in almost 100% of cases. This drug blocks the action of the immune system, which seeks to destroy the fertilized egg as a foreign body. The dose is selected individually.
The role of progesterone is not only to prepare the body for pregnancy, but also to maintain the resulting pregnancy. Its functions:
- relaxation of smooth muscles to prevent miscarriage;
- preparing the mammary glands for feeding.
Thus, with a lack of hormones, the normal course of the gestation process is impossible. Therefore, if indicated, doctors recommend the use of Duphaston during pregnancy.
Duphaston's analogues
Level 4 ATC code matches:
Lutenil
Any substitute for Duphaston must be approved by your doctor. What can replace this drug depends on the patient’s diagnosis and the individual course of the disease. An analogue in composition is the drug Prajisan , other drugs with a similar effect are Utrozhestan , progesterone in ampoules , etc. The price of Duphaston analogues may be slightly lower.
Utrozhestan or Duphaston - which is better?
A comparison of these drugs indicates that both drugs have similar indications for use. But it’s not difficult to determine what the difference is: Utrozhestan, unlike Duphaston, contains natural progesterone from plant raw materials. Which is better - Duphaston or Utrozhestan - during pregnancy can only be determined individually. But Utrozhestan also has a sedative effect on the body. Sometimes both drugs are prescribed simultaneously during pregnancy.
Which is better: Duphaston or Norkolut?
Norkolut is also used in gynecology. However, it has a different active ingredient – norethisterone. This is a cheaper drug, but you can choose one or another drug only after consulting a doctor.
Prajisan or Duphaston - which is better?
Prajisan is a hormonal drug, an analogue of Duphaston. It has similar indications, but its cost is lower. But still, doctors do not recommend making a decision on replacing funds on your own.
Storage conditions, price and analogues
The drug can be stored for 5 years at a temperature not exceeding +30 degrees. The instructions for use recommend these storage conditions for Duphaston. The price of the drug in pharmacies is from 450 to 550 rubles. The manufacturer of the drug is Solvay Pharmaceuticals B.V., the Netherlands.
You can select analogues based on their therapeutic effect. These are drugs containing progesterone and other gestagenic hormones:
- Utrozhestan;
- Norkolut.
- Prajeesan.
Utrozhestan has the same indications for use as Duphaston. This drug contains a natural hormone obtained from plant materials. Sometimes these two medications are used together. Utrozhestan has a slight sedative effect. In price it is approximately equal to Duphaston.
Norkolut is a cheap and rather old drug. It has another active ingredient - norethisterone.
Prajisan is used in the same cases as Duphaston. It's cheaper. Its active ingredient is progesterone.
It is difficult to say which progestin drug is better. The question of replacing one medicine with another can only be decided by the attending physician, based on the diagnostic results and the characteristics of the patient’s body.
Duphaston and alcohol
Since the drug often has to be taken over a long period, many women are interested in whether it is possible to drink alcohol while taking Duphaston. There is no information about this in the instructions for the drug. At the same time, many reviews indicate that alcohol was consumed in small quantities. However, doctors warn that combining alcohol and hormonal drugs can negatively affect hormonal levels, liver function and provoke other negative phenomena. In addition, the effectiveness of the product when combined with alcohol is significantly reduced. For those who become pregnant on Duphaston, alcohol is strictly contraindicated.
Information about Duphaston: composition and its positive properties
The main active ingredient of Duphastoan is dydrogesterone. One dose tablet contains 10 or 20 mg of Dydrogesteronum. This is a synthetic analogue of the female hormone of the reproductive system - progesterone, which ensures the successful implantation of the egg and “protects” it.
Just a few years ago, synthetic hormones were produced in ampoules and used intravenously. Such treatment during pregnancy frightened many women. Now the drug is tableted and in a convenient blister; it is easy to take orally while at home. In addition, dydrogesterone acts directly on the uterus.
Duphaston during pregnancy and lactation
The instructions indicate that the drug can be taken during pregnancy. Taking pills during pregnancy is possible in the early stages to prevent miscarriage. Therefore, Duphaston during early pregnancy is prescribed to women who previously suffered from a habitual abortion, or who had a frozen pregnancy. But, as a rule, the doctor recommends that such patients take Duphaston when planning a pregnancy. Whether the drug can be taken, how much to take and how to take Duphaston when planning a pregnancy, the doctor determines after the woman takes tests for progesterone. In the process of discussing the drug Duphaston during pregnancy, reviews from doctors indicate that this drug should be prescribed only after a comprehensive and thorough examination of the patient.
As a rule, during pregnancy planning, the drug is taken for 3-6 months. You need to drink the product from 11 to 25 days. But this scheme is relevant only for women whose monthly cycle is 28 days. The doctor will tell you how much to drink for a different cycle length.
It is also important to know how to stop taking this medicine during pregnancy. Provided that pregnancy occurs while taking the pills, Duphaston should continue to be taken. During gestation, the dosage is 20 mg of the drug per day (in two doses). You should also consider how to properly stop Duphaston during pregnancy. You should definitely consult your doctor about how to reduce the dose and until what week you take the pills. The withdrawal regimen during pregnancy involves taking the drug until the 20th week of pregnancy, but sometimes the period until which time to take the medicine depends on the individual health status of the expectant mother. Some women are advised to stop as early as 16 weeks. But in any case, only a gynecologist should recommend in detail how to cancel Duphaston during pregnancy. You cannot be guided by the advice that other women write on forums or in reviews about the product. After taking and after stopping the drug, it is important to regularly monitor the woman’s condition. During pregnancy, in some cases, Duphaston and Proginova are prescribed simultaneously.
Often pregnant women are interested in how Duphaston affects the body as a whole, in particular, whether they get better from it. It should be noted that weight gain during pregnancy is a physiological process and is not associated with taking pills.
Duphaston's reception
Very often the drug is prescribed during the period of preparation for conception, when there are medical indications. In such cases, the woman continues to take it throughout the first trimester even after fertilization occurs. 1 tablet 2 times a day is enough, but the regimen may vary depending on the individual characteristics of the pregnant woman. You cannot independently introduce changes to the gynecologist’s prescriptions, much less increase or decrease doses. Even if the expectant mother forgot to take the drug on time, she can do this in the next 6 hours, the level of the hormone in the blood will not change dramatically.
There is no need to take the drug if the placenta is formed (18 weeks).
If the hormone levels are normal, Duphaston is discontinued gradually, the dosage is reduced to 1 tablet per week. Rapid completion of the dose can cause bleeding and subsequent miscarriage.
Reviews about Duphaston
Women taking hormonal pills Duphaston leave positive reviews in most cases. It is often noted online that the medicine helps to get pregnant, that is, it increases the likelihood of conception.
Reviews of Duphaston when planning pregnancy indicate that if you follow the dosage regimen and under the supervision of doctors, you can get the desired result. However, whether this remedy helps you get pregnant in case of infertility depends on whether the diagnosis was made correctly. Women also write on forums that the drug can significantly alleviate symptoms during menopause.
There are also many positive reviews about the use of the drug for endometriosis , for cysts , for polycystic ovary syndrome , for ovarian cysts etc. The drug is often prescribed in combination (for example, with Proginova ’s drugs, etc.).
Women who have treated endometriosis and other diseases with Duphaston sometimes write about side effects. Most often, when taking pills, patients experience the following side effects: nausea , diarrhea , abdominal pain , general weakness, and excess weight .
Many patients, taking the pills during pregnancy, were able to give birth to healthy babies. Reviews of Duphaston for cycle disorders in most cases indicate that after a course of taking pills, the monthly cycle has stabilized. There are also often positive reviews about Duphaston for delayed periods. Experts on the network also often discuss Duphaston. Reviews from doctors for fibroids and other gynecological diseases indicate that experts consider this drug to be effective.
Among other things, it is often discussed online whether Duphaston is hormonal or not. Patients ask questions about whether the pills are hormonal or not, and to specialists. There are many reviews from those who have been helped by taking the pills to get pregnant. On forums, women discuss whether it is possible to get pregnant while taking the drug, whether it affects ovulation, in particular, whether it suppresses ovulation or not. There are often descriptions of individual situations, for example: “I take the drug, but I don’t have my period,” “I drank it for 10 days, but I don’t have my period.”
Women have many questions about taking the drug, which they ask specialists online. People often ask whether it is possible to take Duphaston during menstruation, whether taking it affects the level of hCG , and whether it is possible to gain weight from it.
Reviews
When reviewing reviews of Duphaston on forums, be very careful! Do not attempt to take or, on the contrary, discontinue this drug on your own!
By trusting “well-wishers” in the community, you risk losing your baby. And, unfortunately, and not your recent “advisers” will be held responsible Therefore, ask all questions only to your gynecologist !
Women who took Duphaston during pregnancy can be divided into several groups. All divisions are conditional and made on the basis of feedback from the women themselves.
In the first group , taking Duphaston did not give the desired effect. In this case, women experienced pregnancy failure in the early stages due to urinary tract infections, as a consequence of the illness they had experienced, stress, bad habits, etc.
In the second group , taking Duphaston resulted in the birth of a child. Most often, women had a long period (from 1 to 10 years) of trying to get pregnant without an additional dose of progesterone, which ended in failure.
In the third group, the drug was prescribed “just in case.” In this case, Duphaston gave a placebo effect, i.e. the resulting pregnancy was reinsured by an additional source of progesterone. The result is the birth of a child.
An analogue of Duphaston is the drug Utrozhestan. It is prescribed for the same symptoms and at approximately the same dose. However, it has its own side effects , so only a gynecologist can prescribe hormone replacement therapy.
We wish you good health and an easy pregnancy!
Why do you need to take progesterone in the first trimester of pregnancy and how does it affect the fetus? The doctor says.
Author: Olga Repka
Duphaston price, where to buy
The price of Duphaston tablets is, on average, 520-800 rubles. You can buy Duphaston in a Moscow pharmacy with a doctor's prescription. How much Duphaston costs in pharmacies in Novosibirsk, Omsk, Samara depends on the place of sale, but, on average, the cost of the drug is the same. At the Ozerki pharmacy the cost of the drug is on average 550 rubles.
The price of Duphaston in a Kharkov pharmacy does not differ from the cost in other cities (Kyiv, Odessa, Zaporozhye, Dnepropetrovsk, etc.). On average, in Ukraine the cost of Duphaston 10 mg (pack of 20 pieces) is 390 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Duphaston tab.
p/o captivity. 10 mg No. 28 JSC Veropharm 778 rub. order - Duphaston tab. p/o captivity. 10mg No. 20AO Veropharm
RUR 567 order
Pharmacy Dialogue
- Duphaston tablets 10 mg No. 28Abbot
RUR 819 order
- Duphaston tablets 10 mg No. 20Abbot/Veropharm
RUB 632 order
Europharm* 4% discount using promo code medside11
- Duphaston 10 mg 28 tablets Abbott Biologicals B.V./Veropharm OJSC
RUB 881 order
- Duphaston 10 mg 20 tablets Abbott Biologicals B.V./Veropharm OJSC
RUR 669 order
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Composition of the medicine
This medication is produced in the form of round, convex white tablets with a dividing strip on one side. The active component of the drug is the synthetic hormone dydrogesterone. Each tablet contains 10 mg of this substance.
The drug also contains additional ingredients specified in the instructions for use:
- compounds of titanium, magnesium, silicon;
- lactose;
- starch;
- hypromellose;
- polyethylene glycol.
The tablets are packaged in blister packs of 20 pieces. One package contains one blister. A photo of the drug can be seen above.
