Magnelis B6 during pregnancy: instructions for use and dosage, indications, contraindications, analogues and reviews

Magnesia during pregnancy

Magnesium salts of fatty acids, along with zinc, iron, calcium, selenium and iodine, are included in most vitamin complexes for pregnant women, such as Elevit Pronatal, Vitrum Prenatal Forte, Complivit Mama. Along with folic acid and vitamin D, magnesium should be taken at least three months before pregnancy.

The human body contains about 20–30 mg of magnesium, the main part (about 70%) is distributed to the skeleton, and the rest to muscles, endocrine glands and blood (30%)

Taking it even before pregnancy allows you to increase the magnesium content to a fairly high standard of 300–350 mg, because no more than 30% of it is absorbed from food. There should not be a shortage of such an important microelement in the blood, because it will be needed during the transfer of genetic information from mother to embryo and for the structure of all cells of the new organism. Its intake is also justified in the first 12 weeks from the day of conception; the microelement is widely used as a neuroprotective agent, protecting the fetus from damage to the brain and nervous system, as well as the uterus from excessive tonic contractions.

Video: gynecologist Soboleva V.V. about the need for magnesium during pregnancy

What is the strength of the drug

Magnesium sulfate is the active part of magnesium-based preparations. Its capabilities are different for each organ system:

nervous system - prevents calcium from passing through the surface membrane of the nerve fiber, lowers acetylcholine for faster transmission of nerve impulses from one cell to another, thereby leveling muscle excitability and relieving tension from smooth muscles;
cardiovascular system - reduces high blood pressure, increases the lumen of blood vessels;
urinary system - increases the daily volume of urine excreted.

Photo gallery: release forms of magnesium sulfate

Magnesium sulfate solution is available in ampoules of 5 ml, 10 ml, 20 ml and 30 ml in two possible concentrations: 20% and 25%

The powder is available in packages of 10, 20, 25 and 50 g

Kirkman Magnesium Sulfate Cream is a gentle, fast-absorbing emulsion containing 100 mg of magnesium sulfate per gram of cream.

Mineral water "MagnesiA" differs from many other mineral waters in its high content of magnesium, the ions of which, in dissolved form, are better absorbed by the body

For drip administration through a vein, ready-made solutions of 5, 25, 33 and 50% concentration are used

Use of magnesium sulfate during pregnancy, its effect on the fetus

Enhanced therapy with magnesium sulfate begins no earlier than 10 weeks, before the uterine receptors are not able to absorb it fully. The exception is electrophoresis with magnesium, prescribed from the 9th week if there is a threat of miscarriage.

And the instructions warn that the active substance of the drug can penetrate through the placenta to the fetus. If there is more magnesium in the mother’s blood than normal, then its excess can affect the development of internal organs and inhibit the nervous system of the new organism. Therefore, the administration of magnesium in increased quantities in the first trimester is accompanied by increased risks and should be justified by tests confirming its acute deficiency.

It is also unfavorable to take it before childbirth, because it can relieve muscle tension from the uterus so much that it stops contracting altogether and so-called secondary weakness of labor occurs. It is used during childbirth - if it is necessary to relieve acute pain, for which 5-20 ml of a 25% solution of magnesium sulfate is injected intramuscularly in combination with other analgesics.

Magnesium sulfate in powder form: permissibility of use during pregnancy

The instructions indicate that the use of magnesium sulfate solution prepared from powder for oral administration at all stages of gestation is unacceptable. If use is necessary, the risks of use must be assessed by a physician.

A solution prepared from magnesium sulfate powder actively combats difficult bowel movements - a frequent companion of pregnant women.

Magnesia - properties of the drug

Magnesia or Epsom salt is a powder of sodium sulfate, which is used for the preparation of suspensions or intravenous injections. This drug is used in the treatment of gynecological, urological, neurological and gastroentorological problems. Depending on the concentration of magnesium sulfate, it affects the human body differently.

Most often, treatment with magnesium is prescribed as an intravenous drip, because intravenously it can immediately inhibit the passage of nerve impulses: the tone of the uterus decreases, and convulsions stop. When the drug is administered intramuscularly, the painful condition disappears after 40 minutes. However, such therapy during the last months of pregnancy or before delivery may weaken labor activity.

Indications for prescribing magnesium sulfate to expectant mothers

Expectant mothers require a special approach. Trying to protect women from side effects of the drug, the drug is administered without the participation of the gastrointestinal tract, through the bloodstream - intravenously and intramuscularly . Indications for these methods are as follows:

threat of miscarriage;
muscle spasms of the limbs;
uncontrolled, sudden seizures - epilepsy;
stone, standing stake, belly - uterine tone;
untimely partial separation of the placenta from the walls of the uterus;

Normally, placental abruption occurs at the final stage of labor, after the birth of a child, but in case of disturbances in normal development, partial placental abruption with massive bleeding is possible both during gestation and in the initial stages of labor.
disruptions in the functioning of the heart associated with a persistent increase in blood pressure or arrhythmia;
eclampsia as the last acute stage of gestosis, when the pressure is already so high that there is a huge risk of cerebral hemorrhage, pulmonary edema, renal and liver failure, as well as fetal death;
heavy metal poisoning;
signs of hypomagnesemia - lack of magnesium in the body. To determine the level of magnesium, blood is taken from a vein on an empty stomach in the morning; taking magnesium-based drugs should be discontinued 3-4 days before the day of the test.

The role of magnesium for a pregnant woman

It is not for nothing that magnesium is called a female microelement, because its deficiency is especially dangerous for women.

During pregnancy, it is important to quickly stop the initial stages of the development of pathology in order to prevent complications for the fetus, which magnesium successfully copes with:

the appearance of uterine tone - magnesium sulfate stabilizes the nervous system, namely the transmission of nerve impulses to muscle tissue, relaxing the muscles and eliminating excessive contraction of the walls of the organ;
metabolic disorders - magnesium is involved in protein synthesis, energy and carbon metabolism, necessary for the growth and development of a new organism;
the appearance of edema - magnesium sulfate increases the volume of urine excreted, regulating water metabolism and preventing fluid retention in tissues;
diagnosing gestational diabetes - magnesium salts slow down the rate of development of diabetes by helping to produce insulin, which regulates blood sugar.

Magnesium also fights fatigue in pregnant women, improving sleep and making it more restful without taking additional sleeping pills.

What does deficiency lead to?

A lack of magnesium in the body will affect all systems. There will be disruptions in the functioning of the heart, nervous regulation, digestive tract, and endocrine glands. Here even a woman’s appearance will be depressing: brittle and peeling nails, thinning and thinning hair, bad teeth.

Symptoms indicating its deficiency

According to statistics, every second person in the world suffers from magnesium deficiency. In pregnant women, a lack of magnesium is fraught with the fact that magnesium will be spent first on the structure of the new body, and what is left will be spent for the needs of the body of the expectant mother. Magnesium deficiency can manifest itself in different ways:

muscle spasms: prolonged pain in the cross-lumbar region;
neck muscle tension;
cramping pain in the lower abdomen;
leg spasms in the shin area, calf muscles, hands at night.

from the nervous system:

nervousness;

apathy;

causeless irritability;

sleep disturbance;

emotional instability;

tearfulness;

decreased performance;

loss of consciousness;

shaking and tingling muscles.

from the heart and blood vessels:

increased blood pressure;

feeling of instability;

spasms of blood vessels in the head;

swelling of the lower extremities;

rhythm disturbance or increased frequency of contractions of the heart muscle;

pain in the heart area;

chilliness even in warm weather due to limited blood flow to spasming muscles;

disturbance of the exchange of electrolytes (sodium, potassium, magnesium) during contraction of the heart muscle;

deposition of calcium in the walls of blood vessels.

from the gastrointestinal tract:

constipation;

bloating.

from the respiratory system:

bronchospasms;

breathing disorder.

from the endocrine system:

disruption of hormone levels;

sugar spikes;

severe weight gain, more than half a kilogram per week.

Video: doctor A. Myasnikov about the signs of magnesium deficiency in the body and ways to replenish it through food

Daily requirement for magnesium during pregnancy

The daily requirement for magnesium is calculated based on the total weight of the woman during pregnancy, namely 10 mg per 1 kg of the woman’s weight.

On average, the figure reaches 400 mg/day. Taking multivitamin complexes and adding magnesium-rich foods to meals helps maintain the required amount of magnesium in the blood.

The maximum dosage when injecting the drug into a vein or muscle is 200 ml of a 20% solution.

Rules for the safe use of Magnelis B6 in different trimesters of gestation

According to the official instructions, Magnelis B6 is not contraindicated for use during pregnancy. Moreover, laboratory studies have not revealed the teratogenic properties of the active substances of the drug in relation to expectant mothers and the developing fetus. Thus, Magnelis B6 can be prescribed to a pregnant woman in any trimester of gestation according to indications.

But, according to experts, the unreasonable use of any medications at the embryonic level of gestation can cause pathology in the development of the baby’s organs. Moreover, this drug, as a rule, is not prescribed at 36-40 weeks of gestation, since its use can cause weak labor .

Indications for use of Magnelis B6 in different trimesters of gestation:

nagging pain in the lower abdomen. Sometimes this condition is normal, but in most cases it occurs due to the accumulation of calcium in the muscles, which causes spasm of the smooth muscles of the uterus, which can lead to miscarriage;
increased irritability, excitability and frequent mood swings. These changes can be associated both with a sharp change in hormonal levels and increased production of progesterone, and with a deficiency of magnesium, which takes part in the activity of the central nervous system, regulates the processes of inhibition and excitation;
cramps and increased swelling that occur due to excess calcium in the body;
hypertonicity of the uterus;
fetoplacental insufficiency and intrauterine growth retardation, resulting from poor supply of nutrients to the baby due to damage to the inner lining of small vessels and blockage of their lumen with blood clots. Magnelis B6 has a beneficial effect on the permeability of vascular walls, prevents thrombus formation and improves microcirculation;
gestosis in late pregnancy.

Contraindications and side effects of magnesium sulfate

Before you start taking it, it is best to familiarize yourself with the list of restrictions and possible reactions to the drug.

Contraindications for use

Restrictions on the use of magnesium sulfate are as follows:

allergy to the active substance;
severe chronic renal failure due to decline in renal function (if creatine clearance is less than 20 ml/min);
arterial hypotension in the form of a decrease in pressure by 20% of normal for the body;
heart rate slows below 60 beats per minute;
two hours before birth;
violation of the frequency and rhythm of breathing;
disturbance of the movement of blood from the atria to the ventricles - atrioventricular conduction of the I-III degree, with disruption of the heart rhythm and blood movement through the vessels.

Side effects of taking magnesium sulfate

Side effects can occur when the body is saturated with magnesium and even receives it in greater quantities than needed.

The state of magnesium oversaturation is called hypermagnesemia and becomes noticeable with its early manifestations:

slow resting heart rate below 60 beats per minute or decreased blood pressure;
the appearance of diplopia - bifurcation and displacement along the horizon of objects that you see;
the appearance of a condition that is described as “thrown into a fever,” when blood suddenly and in large quantities flowed to the head;
an increase in headache due to spasm of the head vessels;
stomach upsets in the form of nausea, vomiting;
breathing problems, even in a state without physical activity;
disturbance, unclear speech;
loss of strength and energy;
suppression, lack of expression of nervous reflexes.

Signs of elevated magnesium levels in the blood become more severe if magnesium therapy is continued:

disturbances in the functioning of the heart, even to the point of cardiac arrest;
excessive sweating;

A strong unpleasant odor of sweat, wet clothes, fungal skin diseases and constantly wet palms are the most common signs of hyperhidrosis.
Read also: Corvalol during pregnancy - is there a danger to the health of the fetus when treated with this drug?
a state of constant tension;
excretion of 2 or 3 liters of urine per day instead of the usual 1–1.5 liters;
absence of uterine contractions.

In children born with an increased amount of magnesium in the blood, whose mothers were administered intravenous magnesium sulfate shortly before birth with severe preeclampsia, the following changes were noticeable:

low activity;
poor functioning of the digestive system;
inactive sucking;
prolonged crying.

Calcium preparations - calcium chloride or calcium gluconate - are used as an antidote for an overdose of Magnesia.
reference book of medicines preparatnik.ru
https://preparatnik.ru/755-magneziya-ukoly-v-ampulah-poroshok-dlya-suspenzii-instrukciya-otzyvy-analogi.html

Interaction of magnesium sulfate with other drugs

Despite the apparent simplicity of the composition, the drug is powerful and active; the instructions for it describe in detail all the conditions for combining with other drugs.

Table: effect of magnesium sulfate on other medications when taken simultaneously

What does it interact with?	Result
Muscle relaxants	Enhancing the effects of peripherally acting muscle relaxants
Antibiotics from the tetracycline group	The effect of tetracyclines may decrease due to a decrease in their absorption from the gastrointestinal tract.
Nifedipine	Severe muscle weakness
Oral anticoagulants (including coumarin derivatives or indanedione derivatives), cardiac glycosides, phenothiazines (especially Chlorpromazine).	Reduced efficiency
Ciprofloxacin, Etidronic acid	Reduced absorption
Streptomycin and Tobramycin	Weakening of action
Ca2+ preparations, ethanol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates	Incompatibility (precipitate forms)

additional information

Serious complications may occur during treatment with magnesium sulfate. If a number of symptoms appear, therapeutic measures should be stopped. In particular, indications for stopping treatment are difficulty breathing, a sharp decrease in blood pressure, and a slowdown in heart rate. These manifestations indicate an overdose of the drug. In case of poisoning, the patient must be provided with timely and adequate assistance. For hypermagnesemia, calcium supplements (calcium chloride or gluconate) are prescribed. These medications are administered intravenously, slowly.

Many women believe that such a dropper (magnesium) during pregnancy can have a negative effect on labor function. Of particular concern to patients is the introduction of medication in the third trimester. In practice, it takes only a few hours for magnesium sulfate to be eliminated. In this regard, receiving therapy before childbirth does not affect its course. In some cases, intravenous infusion of magnesium is the only way to prolong the gestational period. In this regard, experts recommend thinking carefully before refusing therapy. The use of the medication should be carried out under the careful supervision of a doctor, in a hospital setting.

Features of application

Features of use depend on the woman’s well-being, the degree of magnesium deficiency and the method of administration of the drug.

Method of application and dosage of magnesium sulfate

How to take the drug and in what quantity is determined by the doctor observing the woman during her current pregnancy. Here, all prescriptions are individual, depending on the woman’s condition and those complications that interfere with the normal course of pregnancy. The method of introducing magnesium into the body also depends on these same factors.

If you are prescribed magnesium drips, you will have to spend several hours in a horizontal position, but there is a convenient alternative - an infusion pump or a device that administers the medicine intravenously gradually over 5-6 hours and allows you to lead an active lifestyle. Many clinics are equipped with this device, but in limited quantities.

Table: selection of methods for introducing magnesium into the body

Mode of application	Indications	How is it carried out?	Limitations and application features
Droppers with Magnesium Sulfate	Reducing blood pressure and normalizing it; normalization of the nervous system, combating insomnia; fight against edema by removing excess fluid; relieving uterine muscle spasms; reducing the manifestations of sudden muscle contractions.	The woman lies down on the couch and does not get up until the procedure is completed. A nurse is preparing a drip system. The nurse examines the arm and looks for a vein to insert a needle into. Using a rope in the form of a thin rubber wire, the arm is pulled 10–15 cm above the elbow. At this time, the fist on the insertion hand should be clenched. The needle insertion site is disinfected, the needle is inserted into the vein, and fixed with a bandage. The regulator wheel is slowly lowered so that the medicine enters the vein at the desired speed. The tourniquet is removed, the fist can be unclenched. After the solution in the vial is finished, the needle is removed from the vein. The needle insertion site is once again disinfected and covered with sterile cotton wool.	While the solution enters the vein, you should maintain the accepted body position; impulsive movements will only worsen your well-being with unpleasant nausea and pain in the head; during the entire procedure, remain calm, but do not doze off, because the medical staff does not have time to monitor the system and this becomes the woman’s responsibility; administration of the drug into a vein is drip and slow, 8 drops per minute is acceptable. High speed will cause heart rhythm disturbances and even disruption of cerebral blood flow with loss of consciousness; after the end of the administration, you should not be active, you should remain in a horizontal position for half an hour, but you can no longer lie down, but half-sitting; The time of administration and volume are determined by the doctor depending on the severity of the symptoms.
Electropheresis with Magnesium Sulfate	Predisposition to gestosis, blockage of blood vessels with a blood clot, disruption of cerebral blood supply, fluid retention in the body; threat of spontaneous abortion (not earlier than 9 weeks of pregnancy); benign neoplasms with fluid inside on a woman’s ovaries; genital endometriosis, when glandular tissue grows in other organs; improving blood movement in the uterus and placenta; inflammation of the skin; relieving muscle spasms; combating virus attacks; improving metabolism within the body, increasing the effect of taking vitamins and microelements; improvement of general well-being in case of toxicosis with salivation, nausea and vomiting; prolongation of pregnancy in case of threat of premature birth of a child.	Special fabric pockets are impregnated with the solution. Place the electrodes inside the pockets and cover them with oilcloth according to the size of the fabric. On the woman’s stomach, the electrodes are fixed with a special tape, which reliably presses the electrodes through the tissue to the skin and conducts currents better. A program is set on the device depending on the diagnosis and the drug particles penetrate through the subcutaneous fat due to the action of the electric field created by the device. The woman feels a slight tingling or warmth at the site where the electrode is installed. Usually 5 to 10 procedures are prescribed, once a day.	The benefits of the procedure are noticeable already on the second day from the start of exposure; electrophoresis is not recommended for the following conditions: dropsy from fluid retention in the tissues, without the appearance of protein in the urine and pressure surges; a triad of symptoms: body edema, arterial hypertension and the appearance of protein in a general urine test; damage to the nervous system in the form of poor sleep, lethargy, blurred vision; convulsive muscle contractions; violation of the integrity and color of the skin, be it mechanical or dermatological lesions of the skin and even an allergic rash; severe uncontrollable vomiting; bleeding of unknown cause; malignant formations; decreased blood clotting ability; cardiac stimulation and other malformations of the heart and blood vessels. If, during the action of the current, pain, burning or other discomfort is felt during the procedure, the tingling intensifies, a burning sensation or pain appears, the procedure should be abandoned.
Intramuscular injections	In case of a critically dangerous form of gestosis with convulsions, disturbances of consciousness and circulatory disorders; with excessively high blood pressure requiring emergency care; when the muscles of the uterus are tense as a result of increased pressure; elimination of pain in the form of spasms; pain relief during childbirth.	The injection site is disinfected. To anesthetize the injection, a 25% solution of magnesium sulfate is mixed with novocaine or lidocaine. The injection site is the upper right quarter of the buttock. The drug is administered at a rate not exceeding 1 ml per 1 minute. Typically, 10 ml of solution is administered after 4 hours. The positive effect appears within half an hour after the first injection, and soreness in the buttock disappears within one minute after administration.	At the injection site of the needle, there are often lumps that are painful when pressed, which can be smoothed out by local heating of the buttock with a heating pad with hot water or a warm cloth; inflammation or suppuration of tissues is also possible; It is recommended to inject the solution into the muscle slowly, otherwise dizziness, flushing and fever cannot be avoided; the solution is injected with a special magnesium needle (the length of the needle shaft is 80 mm).
Intravenous injections	Treatment of uterine strain after the end of the first trimester; therapy of infectious and inflammatory lesions of the walls of the gallbladder and ducts; for emergency aid for abdominal pain and urination; relieving spasms from the muscles of the limbs, causing the cramps to subside; normalization of the condition after a hypertensive crisis due to a sharp rise in pressure to establish a normal heart rhythm; increased urination; in case of poisoning with salts of heavy metals.	The injection solution is first heated to body temperature, holding the ampoule in the hand for some time. A solution of magnesium from an ampoule can be administered undiluted, but according to indications it is diluted with a solution of sodium chloride (to relieve a hypertensive crisis, for example) or 5% glucose (to combat muscle tone). 5–20 mg of a 20% solution of magnesium sulfate is slowly injected into a vein. Improvement in well-being occurs immediately and continues for the first half hour after administration.	Excessively hasty introduction of the solution into the bloodstream will lead to a sharp rise in pressure and oxygen starvation of the fetus due to impaired blood supply to the placenta; Monitoring of the woman’s well-being during administration is required - in case of pain in the heart area, a sudden attack of nausea, or dizziness, the administration is stopped; the course of treatment is strictly limited to 7 days; depending on the severity of the condition, the drug is administered 1 to 2 times in 24 hours, but not more than 40 ml.
Magnesia baths	Treatment of hypertension and tachycardia; relieving nervous tension, increased nervousness, combating stress; treatment of persistent cramps at night; improving skin movement through blood vessels by relieving spasm of even small vessels.	In the evening, the bath is filled with warm water at 37-39 degrees, in which 100 grams of magnesium sulfate is dissolved. The body should be immersed in the bath up to the level of the heart. Bath time is limited to a quarter of an hour.	Immediately after the bath, it is better to rest in bed for another half hour, since the pressure after the bath remains low for some time; A course of baths is recommended: every other day, a total of 15 baths; 1-2 times a week until the condition improves.

What determines the duration of treatment with magnesium sulfate?

How long the course of treatment will continue depends on the success of eliminating the detected pregnancy problems and on the woman’s body’s response to the drug.

Doses are adjusted taking into account whether the woman’s well-being improves after receiving the drug and the level of magnesium ions in the blood serum (normally 0.8–1 mmol/l).

Important things to know when taking magnesium sulfate

Magnesia is acceptable for use, but with periodic testing for the level of magnesium in the blood for the following diseases of the expectant mother:
disruption of impulse transmission between parts of the heart due to myocardial damage;
infectious diseases of the respiratory system;
inflammation of the digestive organs;
treatment of epileptic seizures.
Before childbirth, the drug should be discontinued to prevent weakness of labor or magnesium poisoning of the fetus. Administration during labor is permissible only in extreme cases, such as preeclampsia.
Possible consequences for the child’s body:
neuromuscular weakness;
brain nutritional disorder;
congenital rickets due to a lack of minerals in the child’s body, when the young body itself is unable to absorb and process them;
hypocalcemia in the form of calcium deficiency.
When first administering a solution of magnesium sulfate, it is worth keeping a solution of calcium gluconate or calcium chloride at the ready in order to neutralize the effect of magnesium if it is not absorbed. But calcium and magnesium must be administered in different hands.

For many years, Magnesia was used to get rid of tetanus, when there were no vaccinations against it. Its inhibitory effect on the nervous system, necessary for high-quality anesthesia, was also widely used.

Indications. Contraindications. Overdose

Indications:

Clinically definite magnesium deficiency.
Alone or in combination with deficiencies of other substances.

Magnelis B6 contains sucrose as an excipient. This should be taken into account by patients who have diabetes.

Contraindications

It is prohibited to take the drug in patients with:

Severe renal failure.
Phenylketonuria.
Individual sensitivity to the components of the drug.

Under medical supervision, it is used in patients with moderate renal failure.

Reception and dosage

The drug should be taken with food and water. The duration of treatment is determined by laboratory parameters. Daily dose, which should be divided into several doses:

For adults 6-8 tablets.
Children over 6 years old: 4-6 tablets, but if the child weighs at least 20 kg.

Overdose

Overdose symptoms:

A sharp decrease in pressure.
Dyspeptic disorders.
Suppression of reflex activity and breathing.
In severe cases, coma and cardiac arrest.

Measures in case of overdose:

Rehydration.
Hemodialysis.
Forced diuresis.

Structural and functional analogues of magnesium allowed during pregnancy

Based on the reaction to the drug and the effectiveness of treatment, the doctor may replace it with an analogue.

Table: structural analogs of magnesium sulfate

Drug name	Compound	Release form	Contraindications other than those indicated for magnesium sulfate	Reception features
Cormagnesin	Magnesium sulfate heptahydrate; sulfuric acid.	Solution for intravenous administration.	The calcium content in the blood is below the permissible limit (from 2.15 to 2.5 mmol/l.); breathing disorders.	During treatment, constant monitoring is required: the level of magnesium in the blood; for urination (at least 100 ml/h); for uninterrupted breathing; for blood pressure.
Magnesium sulfate - Darnitsa	Magnesium sulfate heptahydrate.	Solution for intravenous administration.	Myasthenia gravis or false impairment of motor activity of the muscles of the eye, face and masticatory muscles, respiratory muscles due to their weakness.	When pain relief during labor occurs, the tone of the uterus will decrease, which requires the use of stronger stimulants; A solution of magnesium sulfate in ampoules is used after dilution with solutions: 0.9% sodium chloride; 5% dextrose (glucose).

Table: functional analogues of magnesium sulfate

Name	pharmachologic effect	Compound	Release form	contraindications	Reception features
Asparkam	Regulates metabolic processes; fights heart rhythm disturbances.	Magnesium aspartate tetrahydrate; potassium aspartate hemihydrate; potato starch; talc.	Pills.	Hypersensitivity to the drug; violation of amino acid metabolism; acute and chronic renal failure; hyperkalemia; hypermagnesemia; adrenal insufficiency; impaired AV conduction (AV block I-III stages); myasthenia gravis; hemolysis - destruction of red blood cells in the blood; arterial hypotension (systolic blood pressure less than 90 mm Hg);	It is necessary to control the content of potassium ions in the blood plasma.
Papaverine	Relieves muscle spasms; reduces muscle tone of internal organs; An auxiliary agent for premedication - preliminary medicinal preparation for general anesthesia and surgery; Reduces the excitability of the heart muscle, equalizes pressure and improves conductivity between the parts of the heart.	Papaverine hydrochloride.	Injection; ampoules; pills; candles.	AV block; glaucoma - increased intraocular pressure; severe liver failure; hypersensitivity to papaverine.	The IV solution should be administered slowly, monitoring the reaction to the drug; maintain an interval between intravenous injections of at least 4 hours.
Magnistad	Pyridoxine hydrochloride provides: rapid absorption of magnesium; acceleration of metabolic processes; strengthening the nervous system.	Magnesium lactate dihydrate; pyridoxine hydrochloride (vitamin B6); wheat starch; lactose monohydrate; microcrystalline cellulose; povidone - K90; croscarmellose sodium; stearic acid; magnesium stearate.	Enteric-coated tablets	Hypersensitivity to the composition; severe renal failure (creatinine clearance less than 30 ml/min); phenylketonuria in the form of impaired absorption of amino acids; lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the drug contains lactose).	The drug is prescribed until magnesium levels level out; when taking the medicine on an empty stomach, loose stools are possible; When taking additional calcium and phosphate supplements, maintain an hour break between Magnistad and other medications.

When I was in the hospital during pregnancy, the nurse gave every second girl in the ward a magnesium drip. She also helped me in the fight against edema. But lying with a needle in my hand for a long time was a burden to me. And one day, having decided to speed up the process, I myself increased the speed of introducing the solution into my hand by turning the regulator wheel. And immediately I felt hot and dry in my mouth, and my heart was beating too fast. I didn’t allow myself any more such experiments.

Photo gallery: analogues of magnesium sulfate

The drug Magnesium sulfate-Darnitsa is considered a structural analogue of magnesium sulfate with a similar spectrum of actions

The drug Cormagnesin is multifunctional: it has anticonvulsant, antiarrhythmic, hypotensive, antispasmodic effects

Asparkam is a source of potassium and magnesium ions necessary for the regulation of metabolic processes

Magnistad is prescribed for established magnesium deficiency, with symptoms such as: increased irritability, minor sleep disturbances, gastrointestinal cramps, rapid heartbeat, increased fatigue, pain and muscle spasms, tingling sensation

Papaverine hydrochloride is a good antispasmodic; when administered in medium doses, it has no effect on the nervous system.

Magnelis B6 as a medicine

Magnelis B6 is a domestically produced magnesium preparation that is widely used in gynecological practice, including for expectant mothers. This drug is sold from pharmacies without a doctor's prescription, but its independent use for preventive or therapeutic purposes is strictly prohibited.

Magnelis B6 - over-the-counter magnesium preparation

On the pharmaceutical market, this drug is presented in the form of tablets for oral use . Tablets can be packaged in polymer jars or blisters, which, in turn, are placed in cardboard boxes.

There are two types of medicine:

Magnelis B6 classic;
Magnelis B6 Forte.

Table: active and auxiliary composition of drugs

Trade name of the drug

Active composition

Supporting cast

Therapeutic effect

Estimated cost

Magnelis B6

Magnesium lactate - 470 mg;
pyridoxine hydrochloride (vitamin B6) - 5 mg.

Sucrose;
kaolin;
acacia gum;
Kollidon SR;
magnesium stearate;
carmellose sodium;
talc;
gelatin;
beeswax;
titanium dioxide

antispasmodic;
antiarrhythmic;
antithrombotic.

The drug also regulates metabolic processes and the activity of the central nervous system.

50 tablets - 308 Russian rubles.

Magnelis B6 Forte

Magnesium citrate - 618.43 mg;
pyridoxine hydrochloride (vitamin B6) – 10.00 mg.

Ludipress;
collidon;
Kollidon CL;
macrogol;
magnesium stearate;
titanium dioxide;
hyprolose;
talc;
macrogoal

60 tablets - 480 Russian rubles.

What is the difference between Magnelis B6 and Magnelis B6 Forte

Magnelis B6 and Magnelis B6 Forte are included in the category of magnesium drugs. But there are two main distinguishing features between these medications:

High-quality composition. Magnelis B6 consists of magnesium lactate, which is a derivative of lactic acid and is characterized by a weak degree of absorption, so only half of the magnesium is absorbed from the gastrointestinal tract. Magnelis B6 Forte contains magnesium citrate, a derivative of citric acid, which dissolves quite well in water, which means that its degree of absorption from the digestive system is higher than that of its “brother”.
Quantitative composition. One tablet of Magnelis B6 Forte contains twice as much magnesium and vitamin B6 as the same amount of classic Magnelis B6. Thus, the first is characterized by an enhanced therapeutic effect.

Magnelis B6 forte contains a double dose of active ingredients when compared with the composition of the classic Magnelis B6

This tandem of magnesium and pyridoxine in Magnelis B6 is not accidental. Very often, deficiencies of these microelements in the body are combined with each other and have similar symptoms. Moreover, pyridoxine improves the degree of magnesium absorption, its distribution and accumulation in all tissues of the body. Magnesium, in turn, ensures better penetration of vitamin B6 through the lipid layer of cells.

Table: beneficial properties of magnesium and vitamin B6

Benefits of magnesium for the body

The benefits of vitamin B6

Relaxes the smooth muscles of the muscles of internal organs and blood vessels, relieves spasms;
participates in the processes of protein and DNA production;
helps remove toxins from the body;
regulates the processes of glucose breakdown;
participates in the transmission of nerve impulses;
has a beneficial effect on bone growth;
blocks thrombus formation processes, thereby improving blood microcirculation, including in the vessels of the placenta.

Provides amino acid metabolism;
promotes better absorption of proteins and fats;
prevents nervous and skin disorders.

Foods High in Magnesium

But even before you need serious medications, you can saturate your diet with magnesium in advance by increasing the consumption of those foods that contain a lot of this microelement.

Table: foods high in magnesium

Product Name	Magnesium content in mg per 100 g
Wheat and oat bran	up to 600
Cocoa powder	410
Sesame seeds	355
Cashew	300
Almond	285
Mustard	250
Soya beans	250
Cedar	250
Sprouted wheat	240
Buckwheat	230
Corn and corn flakes	210
Peanut	179
Pumpkin seeds	179
Sea kale (kelp and fucus)	170
Brown rice	160
Barley	150
Oats	135
Swiss chard	132
Millet	130
Walnut kernels	120
Legumes (peas, beans, lentils)	up to 110
Dried dates	84
Spinach	78
Young dandelion greens	75
Parsley	75
Dill	70
Carrot	47

But when increasing the proportion of magnesium in the body, one should not forget about its partner, calcium, without which the increased intake of magnesium will not be fully absorbed by the body.

During pregnancy, women's need for calcium increases to 1500–1800 mg, this is due to the formation of the child's bone tissue and subsequent bone growth, so adding foods with calcium to the diet is also necessary

Calcium and magnesium are directly dependent on each other:

if there is not enough magnesium, calcium begins to stick to the walls of blood vessels, interfering with the movement of blood;
excess calcium causes increased loss of magnesium.

Instructions for safe use

Self-prescription of the drug and dosage regimen is unacceptable. The use of Magnelis B6 is possible only after consulting a doctor and determining the level of magnesium deficiency in the body, as well as taking into account all possible contraindications and side effects.

Treatment with Magnelis B6 lasts until the magnesium level in the blood returns to normal. This usually takes 1 month. It is recommended to take the daily dose prescribed by the doctor orally, divided into 3 doses. Based on the test results, your doctor may adjust your treatment regimen.

Often, expectant mothers, on the recommendation of a doctor, drink Magnelis B6 throughout pregnancy, taking breaks of 2 weeks between courses of taking the drug. This may be due to an increasing need for macronutrients, poor nutrition, and possible problems with its absorption.

All magnesium preparations have some features regarding their administration:

They are not taken together with calcium supplements, as this reduces the absorption of magnesium. If a woman, along with a lack of magnesium, also has an additional need for calcium, then first you need to eliminate the magnesium deficiency .
Magnesium reduces the effect of oral thrombolytic agents, reduces the absorption of iron and the absorption of tetracycline antibiotics.

These points are taken into account by the doctor before prescribing Magnelis B6.

Contraindications and possible side effects

Magnelis B6 is safe for the child and does not cause negative reactions either at the beginning of pregnancy, when the embryo is just forming, or at the end. But taking the drug may be accompanied by:

abdominal pain,
constipation,
nausea,
vomiting,
flatulence.

Allergic reactions are also possible . But it should be noted that these side effects occur very rarely.

Taking Magnelis B6 is contraindicated if:

hypersensitivity to its constituent components;
phenylketonuria;
severe renal failure.

Magnesium is removed from the body by the kidneys, so if their functioning is disrupted, an overdose of the macroelement and poisoning with it is possible, which manifests itself in a drop in blood pressure, nausea, vomiting, slowing of reflexes, cessation of urine flow into the bladder, respiratory depression, even coma and cardiac arrest.

A pregnant woman should know that magnesium from the blood passes into breast milk, therefore the use of Magnelis B6 and other magnesium preparations is prohibited during breastfeeding.

What are the features of using magnesia?

Magnesia in pregnant women is administered either intravenously or intramuscularly - this is the only way it shows the most noticeable effect. Accordingly, the expectant mother may be offered injections or droppers with this drug. It is also worth understanding that magnesium is also available in powder form - but this option usually gives an exclusively laxative effect.

It is important to remember a number of nuances that arise when injecting or dropping magnesium. For example, it is worth considering that such injections are painful. If the drug was administered incorrectly, there is a risk of inflammation and even tissue death. The solution must be warmed before administration. Injection therapy requires a long needle.

The drug must be administered slowly - this is important so as not to sharply reduce the woman’s blood pressure. Therefore, IV drips are often carried out for several hours.

How much and what is done with magnesium?

Magnesia is used to relieve many pathological conditions, but this drug, if administered incorrectly or if the dosage is not observed, can be harmful to health:

How much does magnesium cost?

The price of magnesia is low, the drug is available to almost every person. The cost depends on the dosage of the drug, the form of its release and the concentration of the solution. It is possible that prices at different sales points will differ slightly, however, the average price for magnesia is as follows:

20 g of powder – 4-9 rubles.

10 g of powder – 3-8 rubles.

10 ampoules of 25% solution, 5 ml each – 18-22 rubles.

10 ampoules of 25% solution, 10 ml each – 27-45 rubles.

How many days do you take magnesium drops during pregnancy?

The duration of use of magnesia during pregnancy is absolutely individual. Sometimes the drug is prescribed once to stabilize a woman’s condition. In some cases, especially with severe gestosis, a course of drips is prescribed, which most often consists of 10 days. In any case, the duration of treatment will be determined by the doctor, focusing on the patient’s well-being.

How long does a magnesium injection last?

The duration of action of a magnesium injection depends on how the drug was administered. When administered intravenously, the effect lasts for 30 minutes, and when administered intramuscularly, it lasts for a period of 3 to 4 hours.

If magnesia was administered intravenously, the effect occurs almost instantly, and if intramuscularly, then after an hour.

How many times can you do magnesia?

If the patient has no contraindications to the administration of magnesia, then it can be done as many times as the patient’s condition requires.

How many times a day can you inject magnesium?

Magnesia injection is given no more than 1-2 times a day.

Author of the article: Alekseeva Maria Yuryevna, general practitioner, website specifically for the site

Unfortunately, pregnancy does not always proceed smoothly, and the expectant mother is sometimes forced to stay in the hospital. Hospitals often use the drug magnesia (magnesium sulfate) intravenously during pregnancy to prevent miscarriage. We will talk about why this is necessary and what side effects are possible in this article.

Magnesia, or magnesium sulfate, is widely used in modern medicine. It exists in the form of a suspension and injections, which are made from powder. During pregnancy, magnesium injections and magnesium drips are prescribed. In this case, intravenous administration of the drug is more preferable, since the injections are very painful and leave characteristic “bumps” at the injection site. Most often, magnesium is prescribed to expectant mothers for uterine tone, when there is a risk of miscarriage or premature birth. In this case, both intramuscular and intravenous administration of the drug are equally useful.

Let's try to figure out why magnesium is injected during pregnancy. The list of medical indications is quite wide:

uterine tone,
severe course of gestosis,
development of eclampsia,
severe swelling,
lack of magnesium in the body,
convulsive syndrome,
hypertension in the expectant mother.

Magnesia has a vasodilating effect, relaxes muscle tone, lowers blood pressure and has a diuretic effect, which allows you to remove excess fluid from the body.

When prescribing this drug, you should know some features: magnesia is administered very slowly, after warming the solution to body temperature. When administering magnesium intramuscularly during pregnancy, the dosage is selected strictly individually, using a long thin needle. When administered intravenously, the dropper is also placed for a long time, since jet administration of the drug is dangerous. In addition, electrophoresis with magnesium is prescribed during pregnancy. In this case, the drug is administered absolutely painlessly and effectively.

What are the benefits of magnesium for pregnant women?

A drug such as magnesia is a heptahydrate of magnesium sulfate (magnesium salt) of sulfuric acid. It is often called Epsom salt, because in the 17th century it was extracted from a mineral spring and was quite widely and actively used both in medicine and in agriculture, as well as in industry. Since the beginning of the 20th century, magnesia has been used to correct seizures.

Magnesia is prescribed during pregnancy because... it has many important and useful properties that allow it to maintain the “interesting position” itself, and also protects the expectant mother from a number of pathological situations. For example, magnesia is often offered to ladies expecting a baby for a number of reasons:

It allows you to relax the walls of blood vessels
Normalizes blood pressure
Relieves hypertension
Responsible for muscle relaxation
Has a calming effect
Provides relief from cramps
Improves women's well-being
Responsible for ridding the pregnant woman of edema (which is extremely important for gestosis)

In this regard, this drug is often offered to women with gestosis, especially aggravated by convulsions, nephropathy, especially noted in the 3rd trimester, eclampsia and thrombophlebitis, increased blood pressure, and serious edema. Magnesium is also suggested if there is not enough of it in the body.

As doctors note, the effect of magnesia is quite broad. It is involved in metabolism, for example, such an important substance for the condition of the mother and fetus as calcium. In addition, magnesium helps relax muscles and helps normalize the woman’s condition due to the fact that magnesium sulfate reduces the activity of substances that are responsible for transmitting impulses from the nervous system to nerves in the periphery.

In addition, magnesium helps strengthen cell membranes. Therefore, magnesia is often offered to pregnant women if they have:

Threat of premature birth
Preeclampsia
Conditions complicated by seizures
Severe hypertension
Encephalopathy
Stagnation of urine in the body

Also, indications for prescribing magnesium to pregnant women is the need to remove heavy metals from the body.

Why is magnesium prescribed to pregnant women?

Magnesia, or magnesium sulfate, has a number of specific properties that help treat certain diseases and conditions of a pregnant woman and prevent the development of complications and miscarriages. In particular, magnesium normalizes, relaxes the walls of blood vessels, accelerates the removal of fluid from the body, and relaxes muscle muscles. Thus, during pregnancy, magnesia is prescribed for eclampsia, with nephropathy and convulsions, swelling, high blood pressure (hypertension), and a predisposition to thrombophlebitis. Magnesium is also administered in case of acute deficiency in the body of a pregnant woman and in case of an existing threat.